PMID- 37051985
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230414
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 73
IP  - 4
DP  - 2023 Apr
TI  - Comparison of the modified ligation of intersphincteric fistula tract (LIFT) with 
      Incision thread drawing method on serum IgA and IL-10 levels in high simple anal 
      fistula.
PG  - 792-795
LID - 10.47391/JPMA.6086 [doi]
AB  - OBJECTIVE: To compare the effect of different techniques on serum immunoglobulin 
      A and interleukin-10 in patients with high simple anal fistula. METHODS: .The 
      cross-sectional study was conducted at Dongyang People's Hospital, Weishan, 
      China, from January 2019 to April 2021, and comprised patients with high simple 
      anal fistula who were randomly and equally divided into Group A getting treatment 
      with modified ligation of intersphincteric fistula tract, and Group B getting 
      treatment with incision-thread-drawing method. Serum immunoglobulin A and 
      interleukin-10 as well as the Wexner score were compared between the groups. Data 
      was analysed using SPSS 25. RESULTS: Of the 140 patients, there were 70(50%) in 
      each of the two groups. There were 125(89.2%) male subjects overall. The mean age 
      in Group A was 38.91+/-8.91 years, while in Group B it was 38.20+/-8.51. Mean 
      hospital stay in Group A was shorter than that in Group B (p<0.001). Mean serum 
      immunoglobulin A and interleukin-10 values were not significantly different at 
      baseline, but on day 7 post-surgery, the difference was significant between the 
      groups (p<0.05). Likewise, Wexner score was significantly different at 3 months 
      post-surgery (p<0.05). There was no significant difference in the incidence of 
      postoperative complications between the groups (p=0.730). CONCLUSIONS: The 
      modified ligation of intersphincteric fistula tract method was found to be a 
      better option in the management of patients with high simple anal fistula.
FAU - Cai, Qiaoying
AU  - Cai Q
AD  - Department of Colorectal and Anal Surgery, Weishan Branch of Dongyang People's 
      Hospital, Dongyang, China.
FAU - Ge, Zhouqin
AU  - Ge Z
AD  - Department of Colorectal and Anal Surgery, Weishan Branch of Dongyang People's 
      Hospital, Dongyang, China.
FAU - Zhang, Bo
AU  - Zhang B
AD  - Department of Colorectal and Anal Surgery, Weishan Branch of Dongyang People's 
      Hospital, Dongyang, China.
FAU - Gong, Wenjing
AU  - Gong W
AD  - Department of Colorectal and Anal Surgery, Zhejiang Provincial People's Hospital, 
      People's Hospital of Hangzhou Medical College, Hangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Humans
MH  - Male
MH  - Adult
MH  - Middle Aged
MH  - Female
MH  - *Interleukin-10
MH  - Cross-Sectional Studies
MH  - Recurrence
MH  - *Rectal Fistula/surgery
MH  - Ligation/methods
MH  - Immunoglobulin A
MH  - Anal Canal/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Modified ligation of intersphincteric fistula tract, LIFT, 
      Incision-thread-drawing method, High simple anal fistula, Immunoglobulin A, IgA, 
      Interleukin 10, IL-10.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:42
CRDT- 2023/04/13 05:23
PHST- 2023/04/14 06:42 [medline]
PHST- 2023/04/13 05:23 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
AID - 11938 [pii]
AID - 10.47391/JPMA.6086 [doi]
PST - ppublish
SO  - J Pak Med Assoc. 2023 Apr;73(4):792-795. doi: 10.47391/JPMA.6086.