PMID- 37052256
OWN - NLM
STAT- MEDLINE
DCOM- 20230726
LR  - 20230909
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 12
IP  - 18
DP  - 2023 Jul
TI  - Poly Ethylene Glycol (PEG)-Based Hydrogels for Drug Delivery in Cancer Therapy: A 
      Comprehensive Review.
PG  - e2300105
LID - 10.1002/adhm.202300105 [doi]
AB  - Hydrogel-based drug delivery systems (DDSs) can leverage therapeutically 
      beneficial outcomes in cancer therapy. In this domain, polyethylene glycol (PEG) 
      has become increasingly popular as a biomedical polymer and has found clinical 
      use. Owing to their excellent biocompatibility, facile modifiability, and high 
      drug encapsulation rate, PEG hydrogels have shown great promise as drug delivery 
      platforms. Here, the progress in emerging novel designs of PEG-hydrogels as DDSs 
      for anti-cancer therapy is reviewed and discussed, focusing on underpinning 
      multiscale release mechanisms categorized under stimuli-responsive and 
      non-responsive drug release. The responsive drug delivery approaches are 
      discussed, and the underpinning release mechanisms are elucidated, covering the 
      systems functioning based on either exogenous stimuli-response, such as photo- 
      and magnetic-sensitive PEG hydrogels, or endogenous stimuli-response, such as 
      enzyme-, pH-, reduction-, and temperature-sensitive PEG hydrogels. Special 
      attention is paid to the commercial potential of PEG-based hydrogels in cancer 
      therapy, highlighting the limitations that need to be addressed in future 
      research for their clinical translation.
CI  - (c) 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
FAU - Wang, Zihan
AU  - Wang Z
AD  - College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
FAU - Ye, Qinzhou
AU  - Ye Q
AD  - Sichuan Agricultural University, Sichuan, 611130, P. R. China.
FAU - Yu, Sheng
AU  - Yu S
AD  - Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, 
      China West Normal University, Nanchong, 637000, P. R. China.
FAU - Akhavan, Behnam
AU  - Akhavan B
AUID- ORCID: 0000-0002-1599-658X
AD  - School of Engineering, University of Newcastle, Callaghan, NSW, 2308, Australia.
AD  - Hunter Medical Research Institute (HMRI), New Lambton Heights, NSW, 2305, 
      Australia.
AD  - School of Physics, The University of Sydney, Sydney, NSW, 2006, Australia.
AD  - School of Biomedical Engineering, The University of Sydney, Sydney, NSW, 2006, 
      Australia.
AD  - Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230501
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hydrogels)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 0 (Polymers)
SB  - IM
MH  - Biocompatible Materials
MH  - *Drug Delivery Systems
MH  - *Hydrogels
MH  - *Neoplasms/drug therapy
MH  - *Polyethylene Glycols
MH  - Polymers
MH  - Humans
OTO - NOTNLM
OT  - PEG
OT  - cancer
OT  - drug delivery system
OT  - hydrogels
OT  - stimuli-responsiveness
EDAT- 2023/04/14 06:00
MHDA- 2023/07/19 06:43
CRDT- 2023/04/13 07:33
PHST- 2023/04/08 00:00 [revised]
PHST- 2023/01/10 00:00 [received]
PHST- 2023/07/19 06:43 [medline]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/04/13 07:33 [entrez]
AID - 10.1002/adhm.202300105 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2023 Jul;12(18):e2300105. doi: 10.1002/adhm.202300105. Epub 
      2023 May 1.