PMID- 37054685
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 2057-1976 (Electronic)
IS  - 2057-1976 (Linking)
VI  - 9
IP  - 3
DP  - 2023 Apr 21
TI  - PID and LQG controllers for diabetes system with internal delay: a comparison 
      study.
LID - 10.1088/2057-1976/accc8d [doi]
AB  - Closed-loop treatment for insulin dependent type 1 diabetes patients is a recent 
      medical practice in insulin delivery (bionic pancreas) which aims to achieve 
      tight control of glucose level in plasma and ensure minimizing risk of 
      hypoglicemia. Among those most popular closed-loop controller strategies, 
      proportional integral derivative (PID) and linear quadratic Gaussian (LQG) 
      controllers are designed and compared for insulin delivery in diabetic patients. 
      The controllers are designed based on individual and nominal model which is to 
      study the ability of each controller in order to maintain blood glucose 
      concentration for similar patient's dynamic. The comparison is conducted 
      numerically not only for for patients suffering type 1 diabetes mellitus (T1DM), 
      but also type 2 diabetes mellitus (T2DM), and double diabetes mellitus (DDM) in 
      the present of internal delay systems, which causes instability. The responses 
      show that the proposed PID controller is better at maintaining the blood glucose 
      level in the normal range for a longer delay of delay in hepatic glucose 
      production. The patient with longer performing physical exercise has lower 
      oscillation peaks in blood glucose concentration.
CI  - (c) 2023 IOP Publishing Ltd.
FAU - Syafiie, S
AU  - Syafiie S
AUID- ORCID: 0000-0003-4526-8265
AD  - Faculty of Engineering - Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - AlHarbi, Fahd
AU  - AlHarbi F
AD  - Faculty of Engineering - Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Alshehri, Abdullah Ali
AU  - Alshehri AA
AD  - Faculty of Engineering - Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Hasanain, Bassam
AU  - Hasanain B
AUID- ORCID: 0000-0001-9785-7702
AD  - Faculty of Engineering - Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230421
PL  - England
TA  - Biomed Phys Eng Express
JT  - Biomedical physics & engineering express
JID - 101675002
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Humans
MH  - Algorithms
MH  - Blood Glucose
MH  - Computer Simulation
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Glucose
MH  - *Diabetes Mellitus, Type 1/complications
MH  - Insulin
OTO - NOTNLM
OT  - LQG
OT  - LQG controllers for diabetes system
OT  - PID
OT  - comparisons
OT  - delay
OT  - internal
EDAT- 2023/04/14 06:00
MHDA- 2023/04/25 06:42
CRDT- 2023/04/13 18:22
PHST- 2023/03/17 00:00 [received]
PHST- 2023/04/13 00:00 [accepted]
PHST- 2023/04/25 06:42 [medline]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/04/13 18:22 [entrez]
AID - 10.1088/2057-1976/accc8d [doi]
PST - epublish
SO  - Biomed Phys Eng Express. 2023 Apr 21;9(3). doi: 10.1088/2057-1976/accc8d.