PMID- 37054732
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 1748-605X (Electronic)
IS  - 1748-6041 (Linking)
VI  - 18
IP  - 3
DP  - 2023 Apr 24
TI  - A biopolymeric mesh enriched with PLGA microparticles loaded with AT101 for 
      localized glioblastoma treatment.
LID - 10.1088/1748-605X/acccc4 [doi]
AB  - Current treatment strategies for glioblastoma (GBM) including surgical resection 
      and adjuvant radio/chemotherapy result in a limited progression-free survival 
      time of patients due to rapidly occurring tumor recurrences. The urgent need for 
      more effective treatments has led to the development of different approaches for 
      localized drug delivery systems (DDSs) offering the advantages of reduced 
      systemic side effects. A promising candidate for the treatment of GBMs is AT101, 
      the R-(-)-enantiomer of gossypol due to its ability to induce apoptosis or 
      trigger autophagic cell death in tumor cells. Here, we present an alginate-based 
      drug-releasing mesh ladened with AT101-loaded PLGA microspheres (AT101-GlioMesh). 
      The AT101-loaded PLGA microspheres were fabricated using an oil-in-water emulsion 
      solvent evaporation method obtaining a high encapsulation efficiency. The 
      drug-loaded microspheres enabled the release of AT101 over several days at the 
      tumor site. The cytotoxic effect of the AT101-loaded mesh was evaluated using two 
      different GBM cell lines. Strikingly, encapsulation of AT101 in 
      PLGA-microparticles and subsequent embedding in GlioMesh resulted in a sustained 
      delivery and more efficient cytotoxic effect of AT101 on both GBM cell lines. 
      Thus, such a DDS holds promise for GBM therapy likely by preventing the 
      development of tumor recurrences.
CI  - (c) 2023 IOP Publishing Ltd.
FAU - Hellmold, Dana
AU  - Hellmold D
AUID- ORCID: 0000-0001-9891-4342
AD  - Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, 
      Campus Kiel, 24105 Kiel, Germany.
FAU - Arnaldi, Pietro
AU  - Arnaldi P
AD  - Department of Informatics, Bioengineering, Robotics and Systems Engineering, 
      University of Genoa, Via All'Opera Pia 13, 16145 Genoa, Italy.
FAU - Synowitz, Michael
AU  - Synowitz M
AD  - Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, 
      Campus Kiel, 24105 Kiel, Germany.
FAU - Held-Feindt, Janka
AU  - Held-Feindt J
AD  - Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, 
      Campus Kiel, 24105 Kiel, Germany.
FAU - Akbari, Mohsen
AU  - Akbari M
AUID- ORCID: 0000-0003-2902-6557
AD  - Laboratory for Innovations in Microengineering (LiME), Department of Mechanical 
      Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230424
PL  - England
TA  - Biomed Mater
JT  - Biomedical materials (Bristol, England)
JID - 101285195
RN  - S7RL72610R (gossypol acetic acid)
RN  - KAV15B369O (Gossypol)
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Humans
MH  - *Glioblastoma/drug therapy/metabolism
MH  - *Gossypol/pharmacology/therapeutic use
MH  - Surgical Mesh
MH  - Drug Delivery Systems/methods
MH  - *Antineoplastic Agents
MH  - Microspheres
OTO - NOTNLM
OT  - 3D-printing
OT  - glioblastoma
OT  - gossypol
OT  - localized drug delivery
EDAT- 2023/04/14 06:00
MHDA- 2023/04/25 06:42
CRDT- 2023/04/13 19:12
PHST- 2022/12/20 00:00 [received]
PHST- 2023/04/13 00:00 [accepted]
PHST- 2023/04/25 06:42 [medline]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/04/13 19:12 [entrez]
AID - 10.1088/1748-605X/acccc4 [doi]
PST - epublish
SO  - Biomed Mater. 2023 Apr 24;18(3). doi: 10.1088/1748-605X/acccc4.