PMID- 37055094
OWN - NLM
STAT- MEDLINE
DCOM- 20230417
LR  - 20230505
IS  - 1557-8607 (Electronic)
IS  - 0889-8561 (Linking)
VI  - 43
IP  - 2
DP  - 2023 May
TI  - Interstitial Lung Disease and Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis: A Review.
PG  - 379-388
LID - S0889-8561(23)00001-2 [pii]
LID - 10.1016/j.iac.2023.01.001 [doi]
AB  - Interstitial lung disease is a common complication of anti-neutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). It is seen most commonly in microscopic 
      polyangiitis owing to the pathogenic effect of myeloperoxidase in the lung. 
      Oxidative stress, neutrophil elastase release, and expression of inflammatory 
      proteins by neutrophil extracellular traps result in fibroblast proliferation and 
      differentiation and therefore fibrosis. Usually, interstitial pneumonia pattern 
      fibrosis is common and associated with poor survival. Treatment for patients with 
      AAV and interstitial lung disease lacks evidence, and those with vasculitis are 
      treated with immunosuppression, whereas those with progressive fibrosis may well 
      benefit from antifibrotic therapy.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Steward, Matthew
AU  - Steward M
AD  - Academic Department of Respiratory Medicine, Royal Devon University Healthcare 
      NHS Foundation Trust, Exeter, UK; Department of Clinical and Biomedical Sciences, 
      University of Exeter Medical School, Exeter, UK. Electronic address: 
      matt.steward1@nhs.net.
FAU - Thould, Hannah
AU  - Thould H
AD  - Academic Department of Respiratory Medicine, Royal Devon University Healthcare 
      NHS Foundation Trust, Exeter, UK.
FAU - Myat Noe Khin, Aye
AU  - Myat Noe Khin A
AD  - Academic Department of Respiratory Medicine, Royal Devon University Healthcare 
      NHS Foundation Trust, Exeter, UK.
FAU - Gibbons, Michael A
AU  - Gibbons MA
AD  - Academic Department of Respiratory Medicine, Royal Devon University Healthcare 
      NHS Foundation Trust, Exeter, UK; Department of Clinical and Biomedical Sciences, 
      University of Exeter Medical School, Exeter, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230303
PL  - United States
TA  - Immunol Allergy Clin North Am
JT  - Immunology and allergy clinics of North America
JID - 8805635
SB  - IM
MH  - Humans
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/therapy/pathology
MH  - *Lung Diseases, Interstitial/diagnosis/etiology/pathology
MH  - *Microscopic Polyangiitis/pathology
MH  - Lung/pathology
MH  - Fibrosis
OTO - NOTNLM
OT  - Anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - Extracellular traps
OT  - Interstitial
OT  - Lung diseases
OT  - MeSH headings
OT  - Vasculitis
EDAT- 2023/04/14 06:00
MHDA- 2023/04/17 06:41
CRDT- 2023/04/13 20:56
PHST- 2023/04/17 06:41 [medline]
PHST- 2023/04/13 20:56 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
AID - S0889-8561(23)00001-2 [pii]
AID - 10.1016/j.iac.2023.01.001 [doi]
PST - ppublish
SO  - Immunol Allergy Clin North Am. 2023 May;43(2):379-388. doi: 
      10.1016/j.iac.2023.01.001. Epub 2023 Mar 3.