PMID- 37055162 OWN - NLM STAT- MEDLINE DCOM- 20230417 LR - 20230512 IS - 2052-4897 (Electronic) IS - 2052-4897 (Linking) VI - 11 IP - 2 DP - 2023 Apr TI - Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women. LID - 10.1136/bmjdrc-2022-003164 [doi] LID - e003164 AB - INTRODUCTION: To identify the association of the cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 (CDKAL1) gene polymorphism with gestational diabetes mellitus (GDM) in the Chinese population. RESEARCH DESIGN AND METHODS: This case-control study enrolled 835 pregnant women with GDM and 870 pregnant women without diabetes who underwent antenatal examination during 24 to 28 gestational weeks at the Maternal and Child Health Hospital of Hubei Province from January 15, 2018 to March 31, 2019. Trained nurses collected their clinical information and blood samples. CDKAL1 gene rs10440833, rs10946398, rs4712523, rs4712524, rs7754840, rs7756992 and rs9465871 loci were genotyped by Agena MassARRAY system. SPSS V.26.0 software and online SHesis were used to analyze the relationship between CDKAL1 gene polymorphism and GDM susceptibility. RESULTS: After being adjusted for maternal age, prepregnancy body mass index (BMI), parity and family history of type 2 diabetes mellitus (T2DM), CDKAL1 gene rs10440833 (AA vs TT, OR=1.631, 95% CI 1.192 to 2.232), rs10946398 (CC vs AA, OR=1.400, 95% CI 1.028 to 1.905), rs4712523 (GG vs AA, OR=1.409, 95% CI 1.038 to 1.913), rs4712524 (GG vs AA, OR=1.418, 95% CI 1.043 to 1.929) and rs7754840 (CC vs GG, OR=1.407, 95% CI 1.036 to 1.911) polymorphisms were all associated with the increased risk of GDM. In addition, there was a powerful linkage disequilibrium (LD) among rs10946398, rs4712523, rs4712524 and rs7754840 (D'>0.900, r(2)>0.900). And there were significant differences in haplotype CGGC (OR=1.207, 95% CI 1.050 to 1.387) and AAAG (OR=0.829, 95% CI 0.721 o 0.952, p=0.008) between the GDM group and the control group. CONCLUSIONS: rs10440833, rs10946398, rs4712523, rs4712524 and rs7754840 of CDKAL1 gene are associated with GDM susceptibility in central Chinese population. CI - (c) Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Huang, Chengjing AU - Huang C AUID- ORCID: 0000-0003-1794-4975 AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china. FAU - Guo, Yan AU - Guo Y AD - School health center, Wuhan Centers for Disease Prevention and Control, Wuhan, Hubei, China. FAU - Li, Wei AU - Li W AD - Department of Pharmacy, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China. FAU - Xiang, Bing AU - Xiang B AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china. FAU - Zeng, Jing AU - Zeng J AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china. FAU - Zhou, Feng AU - Zhou F AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china. FAU - She, Lu AU - She L AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china. FAU - Zhang, Pei AU - Zhang P AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china. FAU - Wang, Shiwei AU - Wang S AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china. FAU - Liu, Bei AU - Liu B AD - Department of Popular Science, Jinan Health Publicity and Education Center, Jinan, China. FAU - Dai, Qiong AU - Dai Q AD - Department of Popular Science, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China. FAU - Yang, Mei AU - Yang M AD - Research Center for Health Promotion in Women, Youth and Children, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, china 644593079@qq.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - BMJ Open Diabetes Res Care JT - BMJ open diabetes research & care JID - 101641391 RN - EC 2.8.4.5 (CDKAL1 protein, human) RN - EC 2.1.1.- (tRNA Methyltransferases) SB - IM MH - Female MH - Humans MH - Pregnancy MH - Case-Control Studies MH - *Diabetes Mellitus, Type 2 MH - *Diabetes, Gestational/genetics MH - East Asian People MH - Polymorphism, Single Nucleotide MH - *tRNA Methyltransferases/genetics PMC - PMC10106001 OTO - NOTNLM OT - diabetes, gestational OT - genes COIS- Competing interests: None declared. EDAT- 2023/04/14 06:00 MHDA- 2023/04/17 06:41 PMCR- 2023/04/13 CRDT- 2023/04/13 21:12 PHST- 2022/10/09 00:00 [received] PHST- 2023/03/21 00:00 [accepted] PHST- 2023/04/17 06:41 [medline] PHST- 2023/04/13 21:12 [entrez] PHST- 2023/04/14 06:00 [pubmed] PHST- 2023/04/13 00:00 [pmc-release] AID - 11/2/e003164 [pii] AID - bmjdrc-2022-003164 [pii] AID - 10.1136/bmjdrc-2022-003164 [doi] PST - ppublish SO - BMJ Open Diabetes Res Care. 2023 Apr;11(2):e003164. doi: 10.1136/bmjdrc-2022-003164.