PMID- 37056201
OWN - NLM
STAT- MEDLINE
DCOM- 20230905
LR  - 20230905
IS  - 1744-9987 (Electronic)
IS  - 1744-9979 (Linking)
VI  - 27
IP  - 5
DP  - 2023 Oct
TI  - Clinical impact of a novel lipoprotein apheresis treatment on no-option chronic 
      limb-threatening ischemia: Result from the REDUCTION VISCOSITY study.
PG  - 960-967
LID - 10.1111/1744-9987.13991 [doi]
AB  - INTRODUCTION: Lipoprotein apheresis (LA) is a possible adjunct treatment for 
      no-option chronic limb-threatening ischemia (CLTI). This study aimed to assess 
      the impact of a novel LA for no-option CLTI. METHODS: We retrospectively assessed 
      19 patients with no-option CLTI treated using the novel LA. The primary outcome 
      was a change in the skin perfusion pressure (SPP) after treatment with LA, and 
      the secondary outcomes were changes in the viscosity-related laboratory 
      parameters. RESULTS: The wound-healing rate was 68.4%. The SPP at 2-3 weeks after 
      series of LA were significantly higher both in the dorsal (41 vs. 53 mmHg, 
      p = 0.037) and plantar (50.0 vs. 61.0 mmHg, p = 0.018) sides, compared to those 
      at baseline. The viscosity-related laboratory markers were also significantly 
      improved after the treatment; low-density lipoprotein-cholesterol (57.0 vs. 
      43.0 mg/dL, p = 0.002), fibrinogen (333 vs. 258 mg/dL, p < 0.001), and C-reactive 
      protein (0.99 vs. 0.42 mg/dL, p = 0.001). CONCLUSION: The novel LA significantly 
      increased the SPP and improved relevant laboratory findings.
CI  - (c) 2023 International Society for Apheresis and Japanese Society for Apheresis.
FAU - Kojima, Shunsuke
AU  - Kojima S
AD  - Department of Cardiology, Tokyo Bay Medical Center, Urayasu, Japan.
FAU - Nakama, Tatsuya
AU  - Nakama T
AUID- ORCID: 0000-0001-9107-6438
AD  - Department of Cardiology, Tokyo Bay Medical Center, Urayasu, Japan.
AD  - Division of Vascular Surgery, The Jikei University School of Medicine, Tokyo, 
      Japan.
FAU - Suzuki, Toshihiko
AU  - Suzuki T
AUID- ORCID: 0000-0002-4545-9769
AD  - Department of Nephrology, Endocrinology, and Diabetes, Tokyo Bay Medical Center, 
      Urayasu, Japan.
FAU - Obunai, Kotaro
AU  - Obunai K
AD  - Department of Cardiology, Tokyo Bay Medical Center, Urayasu, Japan.
FAU - Watanabe, Hiroyuki
AU  - Watanabe H
AD  - Department of Cardiology, Tokyo Bay Medical Center, Urayasu, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230413
PL  - Australia
TA  - Ther Apher Dial
JT  - Therapeutic apheresis and dialysis : official peer-reviewed journal of the 
      International Society for Apheresis, the Japanese Society for Apheresis, the 
      Japanese Society for Dialysis Therapy
JID - 101181252
RN  - 0 (Lipoproteins)
SB  - IM
MH  - Humans
MH  - Chronic Limb-Threatening Ischemia
MH  - Viscosity
MH  - Retrospective Studies
MH  - Ischemia/therapy
MH  - Treatment Outcome
MH  - *Blood Component Removal
MH  - Lipoproteins
MH  - *Peripheral Arterial Disease
MH  - Risk Factors
OTO - NOTNLM
OT  - chronic limb-threatening ischemia
OT  - hemorheology improvement
OT  - lipoprotein-apheresis
OT  - skin perfusion pressure
EDAT- 2023/04/15 06:00
MHDA- 2023/09/05 06:42
CRDT- 2023/04/14 02:23
PHST- 2023/03/25 00:00 [revised]
PHST- 2022/11/13 00:00 [received]
PHST- 2023/03/31 00:00 [accepted]
PHST- 2023/09/05 06:42 [medline]
PHST- 2023/04/15 06:00 [pubmed]
PHST- 2023/04/14 02:23 [entrez]
AID - 10.1111/1744-9987.13991 [doi]
PST - ppublish
SO  - Ther Apher Dial. 2023 Oct;27(5):960-967. doi: 10.1111/1744-9987.13991. Epub 2023 
      Apr 13.