PMID- 37056231
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230415
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 10
DP  - 2023
TI  - A recombinant porcine reproductive and respiratory syndrome virus type 2 field 
      strain derived from two PRRSV-2-modified live virus vaccines.
PG  - 1149293
LID - 10.3389/fvets.2023.1149293 [doi]
LID - 1149293
AB  - A porcine reproductive and respiratory syndrome virus (PRRSV) type 2 (PRRSV-2) 
      isolate was obtained from lung samples collected from a 4.5-month-old pig at a 
      wean-to-finish site in Indiana, USA, although no gross or microscopic lesions 
      suggestive of PRRSV infection were observed in the lung tissue. Phylogenetic and 
      molecular evolutionary analyses based on the obtained virus sequences indicated 
      that PRRSV USA/IN105404/2021 was a natural recombinant isolate from Ingelvac 
      PRRS((R)) MLV and Prevacent((R)) PRRS, which are PRRSV-2-modified live virus vaccines 
      commercially available in the United States. This study is the first to report 
      the detection of a PRRSV-2 recombinant strain consisting entirely of two modified 
      live virus vaccine strains under field conditions. Based on clinical data and the 
      absence of lung lesions, this PRRSV-2 recombinant strain was not virulent in 
      swine, although its pathogenicity needs to be confirmed by clinical trials.
CI  - Copyright (c) 2023 Trevisan, Magstadt, Woods, Sparks, Zeller, Li, Krueger, Saxena, 
      Zhang and Gauger.
FAU - Trevisan, Giovani
AU  - Trevisan G
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
FAU - Magstadt, Drew
AU  - Magstadt D
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
FAU - Woods, Amy
AU  - Woods A
AD  - AMVC, Frankfort, IN, United States.
FAU - Sparks, Joel
AU  - Sparks J
AD  - AMVC, Frankfort, IN, United States.
FAU - Zeller, Michael
AU  - Zeller M
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
AD  - Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 
      Singapore.
FAU - Li, Ganwu
AU  - Li G
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
FAU - Krueger, Karen M
AU  - Krueger KM
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
FAU - Saxena, Anugrah
AU  - Saxena A
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
FAU - Zhang, Jianqiang
AU  - Zhang J
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
FAU - Gauger, Phillip C
AU  - Gauger PC
AD  - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 
      Ames, IA, United States.
LA  - eng
PT  - Journal Article
DEP - 20230328
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC10086154
OTO - NOTNLM
OT  - MLV vaccines
OT  - NGS
OT  - PRRSV
OT  - evolution
OT  - recombination
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/04/15 06:00
MHDA- 2023/04/15 06:01
PMCR- 2023/01/01
CRDT- 2023/04/14 02:23
PHST- 2023/01/21 00:00 [received]
PHST- 2023/02/27 00:00 [accepted]
PHST- 2023/04/15 06:01 [medline]
PHST- 2023/04/14 02:23 [entrez]
PHST- 2023/04/15 06:00 [pubmed]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2023.1149293 [doi]
PST - epublish
SO  - Front Vet Sci. 2023 Mar 28;10:1149293. doi: 10.3389/fvets.2023.1149293. 
      eCollection 2023.