PMID- 37056932
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230509
IS  - 1449-2288 (Electronic)
IS  - 1449-2288 (Linking)
VI  - 19
IP  - 5
DP  - 2023
TI  - IGF2BP3 Regulates TMA7-mediated Autophagy and Cisplatin Resistance in Laryngeal 
      Cancer via m6A RNA Methylation.
PG  - 1382-1400
LID - 10.7150/ijbs.80921 [doi]
AB  - Translation machinery associated 7 homolog (TMA7) is closely related to 
      proliferation-related diseases. However, the function and regulatory mechanism of 
      TMA7 in laryngeal squamous cell carcinoma (LSCC) remain unclear. The present 
      study aimed to investigate the effect of TMA7 on the occurrence and development 
      of LSCC and to study the mechanism of TMA7. TMA7 is upregulated in LSCC tissues 
      and associated with poor prognosis. After TMA7 downregulation, the autophagy 
      level was increased, and the proliferation, migration, and invasion of LSCC cells 
      were inhibited. The m6A methylated reader IGF2BP3 enhanced the stability of TMA7 
      and reduced the level of autophagy. TMA7 interacted directly with UBA2. 
      Furthermore, the activation of the IGF2BP3-regulated TMA7-UBA2-PI3K pathway is 
      the primary mechanism by which TMA7 inhibits autophagy and promotes the 
      progression of LSCC. The current study revealed that IGF2BP3-mediated TMA7 m6A 
      modification promotes LSCC progression and cisplatin-resistance through UBA2-PI3K 
      pathway, providing new insights into the autophagy-related mechanism, potential 
      biomarkers, and therapeutic targets for LSCC.
CI  - (c) The author(s).
FAU - Yang, Like
AU  - Yang L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Yan, Bingrui
AU  - Yan B
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Qu, Lingmei
AU  - Qu L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated 
      Hospital, Harbin Medical University, Daqing 163316, China.
FAU - Ren, Jingyuan
AU  - Ren J
AD  - Department of Otorhinolaryngology oral maxillofacial Head and neck Surgery, Jilin 
      Tumor Hospital, Changchun, 130012, China.
FAU - Li, Qiuying
AU  - Li Q
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Wang, Jingting
AU  - Wang J
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Kan, Xuan
AU  - Kan X
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Wang, Yakun
AU  - Wang Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Sun, Yanan
AU  - Sun Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Wang, Chao
AU  - Wang C
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin 150086, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230222
PL  - Australia
TA  - Int J Biol Sci
JT  - International journal of biological sciences
JID - 101235568
RN  - Q20Q21Q62J (Cisplatin)
RN  - 0 (MicroRNAs)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - 0 (UBA2 protein, human)
RN  - EC 6.2.1.45 (Ubiquitin-Activating Enzymes)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Humans
MH  - Autophagy/genetics
MH  - *Carcinoma, Squamous Cell/genetics
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - Cisplatin/pharmacology/therapeutic use
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - *Head and Neck Neoplasms/genetics
MH  - *Laryngeal Neoplasms/genetics/metabolism/pathology
MH  - Methylation
MH  - *MicroRNAs/metabolism
MH  - Phosphatidylinositol 3-Kinases/genetics/metabolism
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
MH  - Ubiquitin-Activating Enzymes/genetics/metabolism
MH  - RNA-Binding Proteins/metabolism
PMC - PMC10086756
OTO - NOTNLM
OT  - LSCC
OT  - TMA7
OT  - UBA2
OT  - autophagy.
OT  - cisplatin resistance
OT  - m6A RNA modification
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2023/04/15 06:00
MHDA- 2023/04/17 06:41
PMCR- 2023/01/01
CRDT- 2023/04/14 02:35
PHST- 2022/11/16 00:00 [received]
PHST- 2023/01/08 00:00 [accepted]
PHST- 2023/04/17 06:41 [medline]
PHST- 2023/04/14 02:35 [entrez]
PHST- 2023/04/15 06:00 [pubmed]
PHST- 2023/01/01 00:00 [pmc-release]
AID - ijbsv19p1382 [pii]
AID - 10.7150/ijbs.80921 [doi]
PST - epublish
SO  - Int J Biol Sci. 2023 Feb 22;19(5):1382-1400. doi: 10.7150/ijbs.80921. eCollection 
      2023.