PMID- 37058818
OWN - NLM
STAT- MEDLINE
DCOM- 20230503
LR  - 20230503
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 162
DP  - 2023 Jun
TI  - Dendritic cell vaccines in breast cancer: Immune modulation and immunotherapy.
PG  - 114685
LID - S0753-3322(23)00473-0 [pii]
LID - 10.1016/j.biopha.2023.114685 [doi]
AB  - Breast cancer (BC) is the most common cancer in women worldwide. Although 
      substantial progress has been made in the diagnosis and treatment of breast 
      cancer, the efficacy and side effects of traditional treatment methods are still 
      unsatisfactory. In recent years, immunotherapy including tumor vaccine has 
      achieved great success in the treatment of BC. Dendritic cells (DCs) are 
      multifunctional antigen-presenting cells that play an important role in the 
      initiation and regulation of innate and adaptive immune responses. Numerous 
      studies have shown that DC-based treatments might have a potential effect on BC. 
      Among them, the clinical study of DC vaccine in BC has demonstrated considerable 
      anti-tumor effect, and some DC vaccines have entered the stage of clinical 
      trials. In this review, we summarize the immunomodulatory effects and related 
      mechanisms of DC vaccine in breast cancer as well as the progress of clinical 
      trials to propose possible challenges of DC vaccines and new development 
      directions.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Qian, Da
AU  - Qian D
AD  - Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated 
      to Soochow University, Changshu 215500, China.
FAU - Li, Jialu
AU  - Li J
AD  - Department of Breast Surgery, Changshu Hospital Affiliated to Nanjing University 
      of Chinese Medicine, Changshu 215500, China.
FAU - Huang, Mingyao
AU  - Huang M
AD  - Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou 
      350000, China.
FAU - Cui, Qiuxia
AU  - Cui Q
AD  - Department of Breast Surgery, Changshu Hospital Affiliated to Nanjing University 
      of Chinese Medicine, Changshu 215500, China. Electronic address: 
      fsyy00992@njucm.edu.cn.
FAU - Liu, Xiaozhen
AU  - Liu X
AD  - Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's 
      Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China. 
      Electronic address: liuxiaozhenchina@hmc.edu.cn.
FAU - Sun, Kailv
AU  - Sun K
AD  - Department of Breast Surgery, Changshu Hospital Affiliated to Soochow University, 
      Changshu 215500, China. Electronic address: 20225232115@stu.suda.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230412
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Breast Neoplasms/drug therapy
MH  - Immunotherapy/methods
MH  - Immunity
MH  - Dendritic Cells
MH  - *Cancer Vaccines/therapeutic use
OTO - NOTNLM
OT  - Breast cancer
OT  - Dendritic cell
OT  - Immune regulation
OT  - Immunotherapy
OT  - Vaccines
COIS- Coflict of Interest Statement The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/04/15 06:00
MHDA- 2023/05/03 06:42
CRDT- 2023/04/14 18:02
PHST- 2023/02/10 00:00 [received]
PHST- 2023/03/29 00:00 [revised]
PHST- 2023/04/09 00:00 [accepted]
PHST- 2023/05/03 06:42 [medline]
PHST- 2023/04/15 06:00 [pubmed]
PHST- 2023/04/14 18:02 [entrez]
AID - S0753-3322(23)00473-0 [pii]
AID - 10.1016/j.biopha.2023.114685 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2023 Jun;162:114685. doi: 10.1016/j.biopha.2023.114685. Epub 
      2023 Apr 12.