PMID- 37059368
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20230830
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 98
IP  - 3
DP  - 2023 Sep
TI  - Risk factors for EUS-guided radiofrequency ablation adverse events in patients 
      with pancreatic neoplasms: a large national French study (RAFPAN study).
PG  - 392-399.e1
LID - S0016-5107(23)00376-0 [pii]
LID - 10.1016/j.gie.2023.04.003 [doi]
AB  - BACKGROUND AND AIMS: EUS-guided radiofrequency ablation (EUS-RFA) has been 
      described as a potentially curative option for solid and cystic pancreatic 
      neoplasms. We aimed to assess the safety and efficacy of pancreatic EUS-RFA in a 
      large study population. METHODS: A retrospective study retrieving all consecutive 
      patients who underwent pancreatic EUS-RFA during 2019 and 2020 in France was 
      conducted. Indication, procedural characteristics, early and late adverse events 
      (AEs), and clinical outcomes were recorded. Risk factors for AEs and factors 
      related to complete tumor ablation were assessed on univariate and multivariate 
      analyses. RESULTS: One hundred patients (54% men, 64.8 +/- 17.6 years old) affected 
      by 104 neoplasms were included. Sixty-four neoplasms were neuroendocrine 
      neoplasms (NENs), 23 were metastases, and 10 were intraductal papillary mucinous 
      neoplasms with mural nodules. No procedure-related mortality was observed, and 22 
      AEs were reported. Proximity of pancreatic neoplasms (</=1 mm) to the main 
      pancreatic duct was the only independent risk factor for AEs (odds ratio [OR), 
      4.10; 95% confidence interval [CI), 1.02-15.22; P = .04). Fifty-nine patients 
      (60.2%) achieved a complete tumor response, 31 (31.6%) a partial response, and 9 
      (9.2%) achieved no response. On multivariate analysis, NENs (OR, 7.95; 95% CI, 
      1.66-51.79; P < .001) and neoplasm size <20 mm (OR, 5.26; 95% CI, 2.17-14.29; P < 
      .001) were independently related to complete tumor ablation. CONCLUSIONS: The 
      results of this large study confirm an overall acceptable safety profile for 
      pancreatic EUS-RFA. Close proximity (</=1 mm) to the main pancreatic duct 
      represents an independent risk factor for AEs. Good clinical outcomes in terms of 
      tumor ablation were observed, especially for small NENs.
CI  - Copyright (c) 2023 American Society for Gastrointestinal Endoscopy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Napoleon, Bertrand
AU  - Napoleon B
AD  - Digestive Endoscopy Unit, Hopital Prive Jean Mermoz, Ramsay Sante, Lyon, France.
FAU - Lisotti, Andrea
AU  - Lisotti A
AD  - Digestive Endoscopy Unit, Hopital Prive Jean Mermoz, Ramsay Sante, Lyon, France.
FAU - Caillol, Fabrice
AU  - Caillol F
AD  - Digestive Endoscopy Unit, Paoli Calmettes Institute, Marseille, France.
FAU - Gasmi, Mohamed
AU  - Gasmi M
AD  - Digestive Endoscopy Unit, Hopital Nord, Marseille, France.
FAU - Ah-Soune, Philippe
AU  - Ah-Soune P
AD  - Digestive Endoscopy Unit, Sainte-Musse Hospital, Toulon, France.
FAU - Belle, Arthur
AU  - Belle A
AD  - Department of Gastroenterology and Digestive Oncology, Cochin Hospital, 
      Assistance Publique-Hopitaux de Paris, Paris, France.
FAU - Charachon, Antoine
AU  - Charachon A
AD  - Digestive Endoscopy Unit, Princesse Grace Hospital, Monaco.
FAU - Cholet, Franck
AU  - Cholet F
AD  - Digestive Endoscopy Unit, University Hospital, Brest, France.
FAU - Eyraud, Pierre-Yves
AU  - Eyraud PY
AD  - Hepato-Gastroenterology Department, University Hospital, Grenoble, France.
FAU - Grandval, Philippe
AU  - Grandval P
AD  - Gastroenterology Department, La Timone Hospital, Marseille, France.
FAU - Gonzalez, Jean-Michel
AU  - Gonzalez JM
AD  - Digestive Endoscopy Unit, Hopital Nord, Marseille, France.
FAU - Habersetzer, Francois
AU  - Habersetzer F
AD  - Hepatology and Gastroenterology Unit, University Hospital, Strasbourg, France.
FAU - Koch, Stephane
AU  - Koch S
AD  - Digestive Endoscopy Unit, Jean Minjoz Hospital, Besancon, France.
FAU - Le Rhun, Marc
AU  - Le Rhun M
AD  - Gastroenterology, Centre Hospitalier Universitaire de Nantes, Nantes, France.
FAU - Mangialavori, Luigi
AU  - Mangialavori L
AD  - Digestive Endoscopy Unit, Hopital Prive A Brillard, Ramsay Sante, Nogent sur 
      Marne, France.
FAU - Musquer, Nicolas
AU  - Musquer N
AD  - Gastroenterology, Centre Hospitalier Universitaire de Nantes, Nantes, France.
FAU - Palazzo, Maxime
AU  - Palazzo M
AD  - Digestive Endoscopy Unit, Beaujon University Hospital, Clichy-la-Garenne, France.
FAU - Poincloux, Laurent
AU  - Poincloux L
AD  - Digestive Endoscopy Unit, Estaing University Hospital, Clermont-Ferrand, France.
FAU - Privat, Jocelyn
AU  - Privat J
AD  - Digestive Endoscopy Unit, Vichy Hospital, Vichy, France.
FAU - Sportes, Adrien
AU  - Sportes A
AD  - Digestive Endoscopy, Institut Arnault Tzanck Gastroenterology Unit, 
      Saint-Laurent-du-Var, France.
FAU - Stouvenot, Morgane
AU  - Stouvenot M
AD  - Digestive Endoscopy Unit, Jean Minjoz Hospital, Besancon, France.
FAU - Subtil, Clement
AU  - Subtil C
AD  - Digestive Endoscopy Unit, University Hospital, Bordeaux, France.
FAU - Thomassin, Lucie
AU  - Thomassin L
AD  - Department of Gastroenterology, Rouen University Hospital, University of Rouen, 
      France.
FAU - Vanbiervliet, Geoffroy
AU  - Vanbiervliet G
AD  - Digestive Endoscopy Unit, Archet University Hospital, Nice, France.
FAU - Vidal, Guillaume
AU  - Vidal G
AD  - Digestive Endoscopy Unit, Estaing University Hospital, Clermont-Ferrand, France.
FAU - Vuitton, Lucine
AU  - Vuitton L
AD  - Digestive Endoscopy Unit, Jean Minjoz Hospital, Besancon, France.
FAU - Giovannini, Marc
AU  - Giovannini M
AD  - Digestive Endoscopy Unit, Paoli Calmettes Institute, Marseille, France.
FAU - Barthet, Marc
AU  - Barthet M
AD  - Digestive Endoscopy Unit, Hopital Nord, Marseille, France.
LA  - eng
PT  - Journal Article
DEP - 20230412
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Retrospective Studies
MH  - *Pancreatic Neoplasms/surgery/pathology
MH  - *Radiofrequency Ablation/methods
MH  - *Neuroendocrine Tumors/surgery
MH  - Risk Factors
MH  - *Neoplasms, Cystic, Mucinous, and Serous
EDAT- 2023/04/15 06:00
MHDA- 2023/08/21 06:42
CRDT- 2023/04/14 19:29
PHST- 2023/01/05 00:00 [received]
PHST- 2023/04/03 00:00 [revised]
PHST- 2023/04/06 00:00 [accepted]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/04/15 06:00 [pubmed]
PHST- 2023/04/14 19:29 [entrez]
AID - S0016-5107(23)00376-0 [pii]
AID - 10.1016/j.gie.2023.04.003 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2023 Sep;98(3):392-399.e1. doi: 10.1016/j.gie.2023.04.003. 
      Epub 2023 Apr 12.