PMID- 370596
OWN - NLM
STAT- MEDLINE
DCOM- 19790526
LR  - 20221207
IS  - 0028-4793 (Print)
IS  - 0028-4793 (Linking)
VI  - 300
IP  - 16
DP  - 1979 Apr 19
TI  - Hypertrophic cardiomyopathy and human leukocyte antigen linkage: differentiation 
      of two forms of hypertrophic cardiomyopathy.
PG  - 877-82
AB  - To determine whether hypertrophic cardiomyopathy is associated with a human 
      leukocyte antigen (HLA) phenotype, we tissue-typed 70 unrelated afflicted 
      patients and 86 of their asymptomatic family members (from nine separate 
      kindreds). Forty-five per cent of the white patients had B-12 antigen as compared 
      to 23 per cent in matched control subjects; 69 per cent of black patients had a 
      B-5-complex antigen as compared to 33 per cent in matched controls. Patients with 
      a B-12 or B-5-complex antigen were nonhypertensive and had family members with 
      the disease. Patients without these antigens were severely hypertensive and had 
      no affected family members. Linkage analysis of six families revealed a lod score 
      of 7.7 for asymmetric septal hypertrophy and the HLA region of chromosome 6. We 
      conclude that there is a heritable, nonhypertensive form of hypertrophic 
      cardiomyopathy linked to the HLA loci on chromosome 6 and that a sporadic form is 
      associated with severe, systemic hypertension.
FAU - Darsee, J R
AU  - Darsee JR
FAU - Heymsfield, S B
AU  - Heymsfield SB
FAU - Nutter, D O
AU  - Nutter DO
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Retracted Publication
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (HLA Antigens)
SB  - IM
RIN - Nutter DO, Heymsfield SB, Glenn JF. N Engl J Med. 1983 Jun 9;308(23):1400. PMID: 
      6341849
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Black People
MH  - Cardiomyopathy, Hypertrophic/classification/complications/*genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, 6-12 and X
MH  - Echocardiography
MH  - Female
MH  - *Genetic Linkage
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Hypertension/complications/genetics
MH  - Leukocytes/*immunology
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Phenotype
MH  - Recombination, Genetic
EDAT- 1979/04/19 00:00
MHDA- 1979/04/19 00:01
CRDT- 1979/04/19 00:00
PHST- 1979/04/19 00:00 [pubmed]
PHST- 1979/04/19 00:01 [medline]
PHST- 1979/04/19 00:00 [entrez]
AID - 10.1056/NEJM197904193001602 [doi]
PST - ppublish
SO  - N Engl J Med. 1979 Apr 19;300(16):877-82. doi: 10.1056/NEJM197904193001602.