PMID- 37062358
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20231120
IS  - 2213-2201 (Electronic)
VI  - 11
IP  - 6
DP  - 2023 Jun
TI  - Intravenous Immunoglobulin: Mechanism of Action in Autoimmune and Inflammatory 
      Conditions.
PG  - 1688-1697
LID - S2213-2198(23)00402-6 [pii]
LID - 10.1016/j.jaip.2023.04.002 [doi]
AB  - Intravenous immunoglobulin (IVIG) is the mainstay of therapy for humoral immune 
      deficiencies and numerous inflammatory disorders. Although the use of IVIG may be 
      supplanted by several targeted therapies to cytokines, the ability of polyclonal 
      normal IgG to act as an effector molecule as well as a regulatory molecule is a 
      clear example of the polyfunctionality of IVIG. This article will address the 
      mechanism of action of IVIG in a number of important conditions that are 
      otherwise resistant to treatment. In this commentary, we will highlight 
      mechanistic studies that shed light on the action of IVIG. This will be 
      approached by identifying effects that are both common and disease-specific, 
      targeting actions that have been demonstrated on cells and processes that 
      represent both innate and adaptive immune responses.
CI  - Copyright (c) 2023 American Academy of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Bayry, Jagadeesh
AU  - Bayry J
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Sorbonne Universite, Universite de Paris, Paris, France; 
      Department of Biological Sciences and Engineering, Indian Institute of Technology 
      Palakkad, Palakkad, India. Electronic address: Jagadeesh.bayry@crc.jussieu.fr.
FAU - Ahmed, Eisha A
AU  - Ahmed EA
AD  - Research Institute of McGill University Health Centre, Translational Program in 
      Respiratory Diseases and Department of Pediatrics, McGill University Faculty of 
      Medicine, Montreal, Quebec, Canada.
FAU - Toscano-Rivero, Diana
AU  - Toscano-Rivero D
AD  - Research Institute of McGill University Health Centre, Translational Program in 
      Respiratory Diseases and Department of Pediatrics, McGill University Faculty of 
      Medicine, Montreal, Quebec, Canada.
FAU - Vonniessen, Nicholas
AU  - Vonniessen N
AD  - Research Institute of McGill University Health Centre, Translational Program in 
      Respiratory Diseases and Department of Pediatrics, McGill University Faculty of 
      Medicine, Montreal, Quebec, Canada.
FAU - Genest, Genevieve
AU  - Genest G
AD  - Research Institute of McGill University Health Centre, Translational Program in 
      Respiratory Diseases and Department of Pediatrics, McGill University Faculty of 
      Medicine, Montreal, Quebec, Canada.
FAU - Cohen, Casey G
AU  - Cohen CG
AD  - Research Institute of McGill University Health Centre, Translational Program in 
      Respiratory Diseases and Department of Pediatrics, McGill University Faculty of 
      Medicine, Montreal, Quebec, Canada.
FAU - Dembele, Marieme
AU  - Dembele M
AD  - Research Institute of McGill University Health Centre, Translational Program in 
      Respiratory Diseases and Department of Pediatrics, McGill University Faculty of 
      Medicine, Montreal, Quebec, Canada.
FAU - Kaveri, Srini V
AU  - Kaveri SV
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Sorbonne Universite, Universite de Paris, Paris, France.
FAU - Mazer, Bruce D
AU  - Mazer BD
AD  - Research Institute of McGill University Health Centre, Translational Program in 
      Respiratory Diseases and Department of Pediatrics, McGill University Faculty of 
      Medicine, Montreal, Quebec, Canada. Electronic address: Bruce.mazer@mcgill.ca.
LA  - eng
PT  - Journal Article
DEP - 20230414
PL  - United States
TA  - J Allergy Clin Immunol Pract
JT  - The journal of allergy and clinical immunology. In practice
JID - 101597220
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - *Autoimmune Diseases
MH  - *Immunologic Deficiency Syndromes
MH  - Cytokines
MH  - Immunity, Humoral
OTO - NOTNLM
OT  - Adaptive immunity
OT  - Autoimmunity
OT  - IVIG
OT  - Inflammation
OT  - Innate immunity
OT  - Intravenous immunoglobulin
OT  - Tregs
EDAT- 2023/04/17 06:00
MHDA- 2023/06/12 06:42
CRDT- 2023/04/16 19:22
PHST- 2022/12/07 00:00 [received]
PHST- 2023/04/04 00:00 [revised]
PHST- 2023/04/11 00:00 [accepted]
PHST- 2023/06/12 06:42 [medline]
PHST- 2023/04/17 06:00 [pubmed]
PHST- 2023/04/16 19:22 [entrez]
AID - S2213-2198(23)00402-6 [pii]
AID - 10.1016/j.jaip.2023.04.002 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol Pract. 2023 Jun;11(6):1688-1697. doi: 
      10.1016/j.jaip.2023.04.002. Epub 2023 Apr 14.