PMID- 37062988
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230720
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 98
IP  - 1164
DP  - 2022 Oct 1
TI  - rs10865710 polymorphism in PPARG promoter is associated with the severity of type 
      2 diabetes mellitus and coronary artery disease in a Chinese population.
PG  - 778-787
LID - 10.1136/postgradmedj-2021-140354 [doi]
AB  - BACKGROUND: Relationship between polymorphisms in peroxisome 
      proliferator-activated receptor gamma (PPARG) and progression of type 2 diabetes 
      mellitus (T2DM) and coronary artery disease (CAD) remains to be clarified. 
      METHODS: 635 subjects were divided into T2DM, CAD, T2DM complicated with CAD 
      (T2DM/CAD) and control groups according to diagnostic criteria. The rs10865710 
      and rs3856806 polymorphisms were genotyped, and the severity of T2DM and CAD was 
      evaluated for all subjects. RESULTS: In patients with T2DM, G allele carriers of 
      rs10865710 polymorphism had significantly higher levels of glucose, 
      triglycerides, apolipoprotein B (ApoB) and lipoprotein (a) (Lp(a)) than 
      non-carriers, T allele carriers of rs3856806 polymorphism had significantly 
      higher levels of glucose, low-density lipoprotein cholesterol (LDL-C), ApoB and 
      Lp(a) than non-carriers. In patients with CAD, G allele carriers of rs10865710 
      polymorphism had significantly higher levels of total cholesterol (TC), ApoB and 
      Lp(a) than non-carriers, T allele carriers of rs3856806 polymorphism had 
      significantly higher levels of body mass index, blood pressure, TC, LDL-C and 
      ApoB than non-carriers. Patients with one or two G alleles of rs10865710 
      polymorphism had significantly higher levels of Gensini scores and more diseased 
      coronary branches than those patients without CAD. The rs3856806 polymorphism was 
      not associated with CAD severity, but it was found to be significantly associated 
      with T2DM/CAD, T allele frequency was significantly higher in T2DM/CAD group than 
      that in T2DM/CAD-free group. CONCLUSIONS: The rs10865710 and rs3856806 
      polymorphisms in PPARG are significantly associated with glucose levels in 
      patients with T2DM. The rs10865710 polymorphism is significantly associated with 
      the severity of CAD, which is possibly mediated by hyperlipidaemia and 
      hyperglycaemia.
CI  - (c) Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Song, Yongyan
AU  - Song Y
AD  - Central Laboratory, and Medical Key Laboratory of Clinical Genetics of Sichuan 
      Province, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People's 
      Republic of China.
FAU - Raheel, Tariq Muhammad
AU  - Raheel TM
AD  - Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, Sichuan, People's Republic of China.
FAU - Jia, Aimei
AU  - Jia A
AD  - Department of General Surgery, Affiliated Hospital of North Sichuan Medical 
      College, Nanchong, Sichuan, People's Republic of China.
FAU - Dai, Guowei
AU  - Dai G
AD  - Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Liu, Liang
AU  - Liu L
AD  - Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Long, Xiaobin
AU  - Long X
AD  - Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - He, Chuan
AU  - He C
AUID- ORCID: 0000-0001-9387-0475
AD  - Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu, 
      Sichuan, People's Republic of China.
LA  - eng
GR  - KL012/This research was supported by grants from Medical Key Laboratory of 
      Clinical Genetics of Sichuan Province/
PT  - Journal Article
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Apolipoproteins B)
RN  - 0 (Cholesterol, LDL)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (PPAR gamma)
RN  - 0 (PPARG protein, human)
SB  - IM
MH  - Humans
MH  - Apolipoproteins B
MH  - Cholesterol, LDL
MH  - *Coronary Artery Disease
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - East Asian People
MH  - Glucose
MH  - Polymorphism, Single Nucleotide
MH  - *PPAR gamma/genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - coronary heart disease
OT  - general diabetes
OT  - genetics
EDAT- 2023/04/18 06:00
MHDA- 2023/04/18 06:42
CRDT- 2023/04/17 02:53
PHST- 2021/04/22 00:00 [received]
PHST- 2021/07/04 00:00 [accepted]
PHST- 2023/04/18 06:42 [medline]
PHST- 2023/04/17 02:53 [entrez]
PHST- 2023/04/18 06:00 [pubmed]
AID - 7096838 [pii]
AID - 10.1136/postgradmedj-2021-140354 [doi]
PST - ppublish
SO  - Postgrad Med J. 2022 Oct 1;98(1164):778-787. doi: 
      10.1136/postgradmedj-2021-140354.