PMID- 37064173
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230418
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Associations of MTHFR gene polymorphism with lipid metabolism and risk of 
      cerebral infarction in the Northwest Han Chinese population.
PG  - 1152351
LID - 10.3389/fneur.2023.1152351 [doi]
LID - 1152351
AB  - OBJECTIVE: Genetic variation in the methylenetetrahydrofolate reductase (MTHFR) 
      gene may contribute to the development of cerebral infarction (CI); however, 
      results have been inconsistent across studies with different populations, 
      including studies of the Chinese population. The aim of this study was to analyze 
      the effect of MTHFR gene polymorphism on serum lipid and homocysteine levels 
      among patients with CI in the Northwest Chinese Han population. PATIENTS AND 
      METHODS: A total of 521 CI patients and 524 non-CI controls were enrolled in the 
      study. Polymerase chain reaction and hybridization were utilized to identify 
      MTHFR gene polymorphisms. Multivariate logistic regression analysis was used to 
      assess the associations of MTHFR gene polymorphism with risk of CI. RESULTS: 
      Frequencies of the TT genotype and the T allele were markedly higher among CI 
      patients than among controls. After stratifying our data by sex and age, we 
      determined that these differences in frequency of the TT genotype and the T 
      allele were statistically significant among participants of two different age 
      brackets and among men, but not among women (i.e., there were no statistically 
      significant differences between female patients and female controls). CI patients 
      and control participants with the CT or TT genotype had significantly higher 
      homocysteine (Hcy) levels than those with the CC genotype. Among CI patients, 
      CT/TT carriers showed significantly lower high-density lipoprotein cholesterol 
      (HDL-C) and apolipoprotein A-I (ApoA-I) levels as compared with CC carriers, but 
      there was no significant difference for control participants. Multivariable 
      logistic regression analysis showed that drinking; smoking; diabetes mellitus; 
      levels of Hcy, direct bilirubin (DB), indirect bilirubin (IB), ApoA-I, and total 
      protein (TP); and TT genotype were significant independent risk factors for CI. 
      CONCLUSIONS: The results suggested that the TT genotype of the MTHFR C677T gene 
      polymorphism, which is associated with hyperhomocysteinemia (HHcy), might be of 
      great clinical significance in the identification of new biomarkers for CI and in 
      the development of individualized preventive and therapeutic strategies.
CI  - Copyright (c) 2023 Guan, Ji, Lu, Feng and Ma.
FAU - Guan, Dong
AU  - Guan D
AD  - Department of Pharmacology, The First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Ji, Yichun
AU  - Ji Y
AD  - Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Lu, Xiaoyun
AU  - Lu X
AD  - Department of Biological Science and Bioengineering, Key Laboratory of Biomedical 
      Information Engineering of the Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Feng, Weiyi
AU  - Feng W
AD  - Department of Pharmacology, The First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Ma, Wenbing
AU  - Ma W
AD  - Department of Pharmacology, The First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
AD  - Department of Biological Science and Bioengineering, Key Laboratory of Biomedical 
      Information Engineering of the Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20230331
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC10102478
OTO - NOTNLM
OT  - MTHFR
OT  - Northwest China
OT  - cerebral infarction
OT  - gene polymorphism
OT  - homocysteine
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/04/18 06:00
MHDA- 2023/04/18 06:01
PMCR- 2023/03/31
CRDT- 2023/04/17 03:39
PHST- 2023/01/27 00:00 [received]
PHST- 2023/03/09 00:00 [accepted]
PHST- 2023/04/18 06:01 [medline]
PHST- 2023/04/17 03:39 [entrez]
PHST- 2023/04/18 06:00 [pubmed]
PHST- 2023/03/31 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1152351 [doi]
PST - epublish
SO  - Front Neurol. 2023 Mar 31;14:1152351. doi: 10.3389/fneur.2023.1152351. 
      eCollection 2023.