PMID- 37065671
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230418
IS  - 2424-8002 (Electronic)
IS  - 2424-7723 (Print)
IS  - 2424-8002 (Linking)
VI  - 9
IP  - 2
DP  - 2023
TI  - Preparation and characterization of 3D-printed antibacterial hydrogel with benzyl 
      isothiocyanate.
PG  - 671
LID - 10.18063/ijb.v9i2.671 [doi]
LID - 671
AB  - Benzyl isothiocyanate (BITC) is an isothiocyanate of plant origin, especially the 
      mustard family, which has good antibacterial properties. However, its 
      applications are challenging due to its poor water solubility and chemical 
      instability. We used food hydrocolloids, including xanthan gum, locust bean gum, 
      konjac glucomannan, and carrageenan as three-dimensional (3D)-printing food ink 
      base and successfully prepared 3D-printed BITC antibacterial hydrogel 
      (BITC-XLKC-Gel). The characterization and fabrication procedure of BITC-XLKC-Gel 
      was studied. The results show that BITC-XLKC-Gel hydrogel has better mechanical 
      properties by low-field nuclear magnetic resonance (LF-NMR), mechanical 
      properties, and rheometer analysis. The strain rate of BITC-XLKC-Gel hydrogel is 
      76.5%, which is better than that of human skin. Scanning electron microscope 
      (SEM) analysis showed that BITC-XLKC-Gel has uniform pore size and provides a 
      good carrier environment for BITC carriers. In addition, BITC-XLKC-Gel has good 
      3D-printing performance, and 3D printing can be used for customizing patterns. 
      Finally, inhibition zone analysis showed that the BITC-XLKC-Gel added with 0.6% 
      BITC had strong antibacterial activity against Staphylococcus aureus and the 
      BITC-XLKC-Gel added with 0.4% BITC had strong antibacterial activity against 
      Escherichia coli. Antibacterial wound dressing has always been considered 
      essential in burn wound healing. In experiments that simulated burn infection, 
      BITC-XLKC-Gel showed good antimicrobial activity against methicillin-resistant S. 
      aureus. BITC-XLKC-Gel is a good 3D-printing food ink attributed to strong 
      plasticity, high safety profile, and good antibacterial performance and has great 
      application prospects.
CI  - Copyright: (c) 2023 Author(s).
FAU - Liang, Yunxia
AU  - Liang Y
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Chitrakar, Bimal
AU  - Chitrakar B
AD  - College of Food Science and Technology, Hebei Agricultural University, Baoding, 
      071001, Hebei, China.
FAU - Liu, Zhenbin
AU  - Liu Z
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Ming, Xujia
AU  - Ming X
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Xu, Dan
AU  - Xu D
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Mo, Haizhen
AU  - Mo H
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Shi, Chunyang
AU  - Shi C
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Zhu, Xiaolin
AU  - Zhu X
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Hu, Liangbin
AU  - Hu L
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
FAU - Li, Hongbo
AU  - Li H
AD  - School of Food Science and Engineering, Shaanxi University of Science and 
      Technology, Xi'an, 710021, China.
LA  - eng
PT  - Journal Article
DEP - 20230117
PL  - Singapore
TA  - Int J Bioprint
JT  - International journal of bioprinting
JID - 101709763
PMC - PMC10090813
OTO - NOTNLM
OT  - 3D printing
OT  - Antibacterial hydrogel
OT  - Benzyl isothiocyanate
OT  - Escherichia coli
OT  - Rheological properties
OT  - Staphylococcus aureus
COIS- The authors declare no conflicts of interest.
EDAT- 2023/04/18 06:00
MHDA- 2023/04/18 06:01
PMCR- 2023/01/17
CRDT- 2023/04/17 03:58
PHST- 2022/09/09 00:00 [received]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2023/04/18 06:01 [medline]
PHST- 2023/04/17 03:58 [entrez]
PHST- 2023/04/18 06:00 [pubmed]
PHST- 2023/01/17 00:00 [pmc-release]
AID - IJB-9-2-671 [pii]
AID - 10.18063/ijb.v9i2.671 [doi]
PST - epublish
SO  - Int J Bioprint. 2023 Jan 17;9(2):671. doi: 10.18063/ijb.v9i2.671. eCollection 
      2023.