PMID- 3706577
OWN - NLM
STAT- MEDLINE
DCOM- 19860616
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 250
IP  - 5 Pt 2
DP  - 1986 May
TI  - Independent osmoregulatory control of central and systemic angiotensin II 
      concentrations in dogs.
PG  - R918-25
AB  - In 14 dogs angiotensin (ANG II)-like immunoreactivity was analyzed in 
      simultaneously collected samples of cerebrospinal fluid (CSF) from the anterior 
      part of the third cerebral ventricle and of plasma. Plasma and CSF ANG II were 
      not different in euhydrated conscious dogs (29.3 +/- 2.7 and 30.8 +/- 2.8 pg X 
      ml-1, means +/- SE). During anesthesia CSF ANG II was not significantly altered, 
      but plasma ANG II was more than doubled in comparison with conscious animals. In 
      conscious dogs 24 h of dehydration with sodium-rich food significantly increased 
      ANG II concentration in the plasma (to 59.8 +/- 16.5 pg X ml-1) and CSF (to 71.8 
      +/- 20.1 pg X ml-1). Subsequent rehydration by drinking caused no consistent 
      changes in plasma ANG II within 90 min but reduced CSF ANG II significantly. Salt 
      loading by infusion of 5% saline in seven conscious dogs produced a small but 
      consistent decrease in plasma ANG II by 20%, on average, whereas CSF ANG II rose 
      in five animals. The directions of changes in concentration of central ANG II 
      compared with plasma ANG II suggest that central endogenous ANG II may function 
      as a central osmoregulatory mediator independent from systemic ANG II.
FAU - Simon-Oppermann, C
AU  - Simon-Oppermann C
FAU - Gray, D A
AU  - Gray DA
FAU - Simon, E
AU  - Simon E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 11128-99-7 (Angiotensin II)
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Angiotensin II/blood/*cerebrospinal fluid
MH  - Animals
MH  - Cerebral Ventricles/*metabolism
MH  - Dehydration/blood/cerebrospinal fluid
MH  - Dogs
MH  - Drinking
MH  - Female
MH  - Male
MH  - Osmolar Concentration
MH  - Sodium Chloride/pharmacology
MH  - *Water-Electrolyte Balance
EDAT- 1986/05/01 00:00
MHDA- 1986/05/01 00:01
CRDT- 1986/05/01 00:00
PHST- 1986/05/01 00:00 [pubmed]
PHST- 1986/05/01 00:01 [medline]
PHST- 1986/05/01 00:00 [entrez]
AID - 10.1152/ajpregu.1986.250.5.R918 [doi]
PST - ppublish
SO  - Am J Physiol. 1986 May;250(5 Pt 2):R918-25. doi: 10.1152/ajpregu.1986.250.5.R918.