PMID- 37066443
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230427
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 51
IP  - 4
DP  - 2023 Apr
TI  - Infantile B-lymphoblastic leukemia: a case series and review of the literature.
PG  - 3000605231167789
LID - 10.1177/03000605231167789 [doi]
LID - 03000605231167789
AB  - Infantile leukemia is a rare hematological malignancy that occurs in the first 
      year of life. It is an aggressive disease with peculiar immunophenotypic, 
      cytogenetic, and molecular characteristics. It can be myeloid or lymphoid in 
      origin. More than 80% of cases involve KMT2A gene rearrangement in the 
      lymphoblastic subset, versus 50% in the myeloid subset. In this study, we present 
      three cases of this rare entity to add knowledge about its clinical presentation 
      and diagnostic profiles. These cases of infantile B-lymphoblastic leukemia 
      (B-ALL) were retrospectively reviewed at the Department of Hematology, Section 
      Cytogenetics at Indus Hospital and Health Network. The clinical characteristics, 
      complete diagnostic profile, immunophenotypic profile, fluorescence in situ 
      hybridization (FISH) results, treatments, and outcomes of the patients were 
      assessed. All three infants were girls who presented with hyperleukocytosis, and 
      they were diagnosed by eight-color flow cytometry. FISH studies revealed KMT2A 
      gene rearrangement in two of the three patients. Infantile B-ALL is a 
      biologically distinct disease carrying a poor prognosis. Female preponderance, 
      hyperleukocytosis, and hepatosplenomegaly are common findings in this subgroup. 
      No standard protocol for this rare entity has proven ideal for managing these 
      young infants.
FAU - Mansoor, Neelum
AU  - Mansoor N
AUID- ORCID: 0000-0003-1650-0694
AD  - Department of Hematology & Blood Center, Indus Hospital & Health Network, 
      Karachi, Pakistan.
FAU - Imran, Sadia
AU  - Imran S
AD  - Department of Pediatric Oncology, Indus Hospital & Health Network, Karachi, 
      Pakistan.
FAU - Maqsood, Sidra
AU  - Maqsood S
AUID- ORCID: 0000-0002-2214-9047
AD  - Indus Hospital Research Centre, Indus Hospital & Health Network, Karachi, 
      Pakistan.
FAU - Pasha, Shadab
AU  - Pasha S
AD  - Department of Hematology & Blood Center, Indus Hospital & Health Network, 
      Karachi, Pakistan.
FAU - Jabbar, Naeem
AU  - Jabbar N
AD  - Department of Hematology & Blood Center, Indus Hospital & Health Network, 
      Karachi, Pakistan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
SB  - IM
MH  - Female
MH  - Male
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Retrospective Studies
MH  - *Myeloid-Lymphoid Leukemia Protein/genetics
MH  - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/genetics/pathology
PMC - PMC10127210
OTO - NOTNLM
OT  - Infant
OT  - KMT2A gene rearrangement
OT  - acute leukemia
OT  - flow cytometry
OT  - fluorescence in situ hybridization
OT  - immunophenotype
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/04/18 06:00
MHDA- 2023/04/18 10:16
PMCR- 2023/04/17
CRDT- 2023/04/17 04:10
PHST- 2023/04/18 10:16 [medline]
PHST- 2023/04/17 04:10 [entrez]
PHST- 2023/04/18 06:00 [pubmed]
PHST- 2023/04/17 00:00 [pmc-release]
AID - 10.1177_03000605231167789 [pii]
AID - 10.1177/03000605231167789 [doi]
PST - ppublish
SO  - J Int Med Res. 2023 Apr;51(4):3000605231167789. doi: 10.1177/03000605231167789.