PMID- 37066843
OWN - NLM
STAT- Publisher
LR  - 20230417
IS  - 2046-5556 (Electronic)
IS  - 0264-8725 (Linking)
DP  - 2023 Apr 17
TI  - Comparison of effects of different anesthesia methods on immune function and 
      liver function of liver cancer patients after operation.
PG  - 1-11
LID - 10.1080/02648725.2023.2201521 [doi]
AB  - Liver cancer, one of the most common malignant tumors, has seriously threatened 
      people's physical and mental health. The paper was conducted to investigate the 
      functions of two different anesthesia methods on Tumor necrosis factor-alpha (TNF-alpha), 
      C-reactive protein (CRP) and T lymphocyte subsets in patients undergoing liver 
      cancer resection, and to explore the liver function impact of patients undergoing 
      liver cancer surgery. 80 liver cancer patients were split into propofol 
      intravenous anesthesia group and sevoflurane inhalation anesthesia group. The 
      patient's operation-related indicators and changes in TNF-alpha, CRP and T lymphocyte 
      subsets before anesthesia, after anesthesia, 1 day after anesthesia, and 3 days 
      after anesthesia were calculated. The levels of TNF-alpha and CRP in the two groups 
      after operation were clearly higher than those before anesthesia, but there was 
      no obvious difference between the two groups. After operation, the TNF-alpha of the 
      propofol intravenous anesthesia group was lower than the sevoflurane inhalation 
      anesthesia group. The CD3+, CD4+ and CD4+/CD8+ levels in both groups recovered to 
      the pre-anaesthesia level 3 days after the operation. The levels of ALT, AST, ALB 
      and TBIL returned to normal at d4 in both propofol intravenous anesthesia and 
      sevoflurane inhalation anesthesia groups. Compared with evoflurane inhalation 
      anesthesia for patients with liver cancer, intravenous anesthesia with propofol 
      can reduce the body's inflammatory response to a certain extent, has weak 
      inhibitory effect on T lymphocyte immune function, and a smaller effect on liver 
      function.
FAU - Feng, Xi
AU  - Feng X
AD  - Department of Anesthesiology, General Hospital of the Yangtze River Shipping 
      (Wuhan Brain Hospital), Hankou, China.
FAU - Ma, Yao
AU  - Ma Y
AD  - Department of Anesthesiology, Tianyou Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuchang, China.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Anesthesiology, General Hospital of the Yangtze River Shipping 
      (Wuhan Brain Hospital), Hankou, China.
FAU - Peng, Pai
AU  - Peng P
AD  - Department of Anesthesiology, General Hospital of the Yangtze River Shipping 
      (Wuhan Brain Hospital), Hankou, China.
FAU - Zeng, Xiaohua
AU  - Zeng X
AD  - Department of Anesthesiology, General Hospital of the Yangtze River Shipping 
      (Wuhan Brain Hospital), Hankou, China.
FAU - Shen, Lei
AU  - Shen L
AD  - Department of Anesthesiology, General Hospital of the Yangtze River Shipping 
      (Wuhan Brain Hospital), Hankou, China.
FAU - Hu, Tingting
AU  - Hu T
AD  - Department of Anesthesiology, General Hospital of the Yangtze River Shipping 
      (Wuhan Brain Hospital), Hankou, China.
FAU - Luo, Qin
AU  - Luo Q
AD  - Department of Anesthesiology, General Hospital of the Yangtze River Shipping 
      (Wuhan Brain Hospital), Hankou, China.
LA  - eng
PT  - Journal Article
DEP - 20230417
PL  - England
TA  - Biotechnol Genet Eng Rev
JT  - Biotechnology & genetic engineering reviews
JID - 8510274
SB  - IM
OTO - NOTNLM
OT  - Liver cancer
OT  - anesthesia
OT  - immune
OT  - propofol
OT  - sevoflurane
EDAT- 2023/04/18 06:00
MHDA- 2023/04/18 06:00
CRDT- 2023/04/17 05:42
PHST- 2023/04/17 05:42 [entrez]
PHST- 2023/04/18 06:00 [pubmed]
PHST- 2023/04/18 06:00 [medline]
AID - 10.1080/02648725.2023.2201521 [doi]
PST - aheadofprint
SO  - Biotechnol Genet Eng Rev. 2023 Apr 17:1-11. doi: 10.1080/02648725.2023.2201521.