PMID- 37068356
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20231112
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 196
DP  - 2023 Jun 1
TI  - Characteristics of Right Ventricular to Pulmonary Arterial Coupling and 
      Association With Functional Status Among Older Aged Adults from the Multi-Ethnic 
      Study of Atherosclerosis.
PG  - 41-51
LID - S0002-9149(23)00156-X [pii]
LID - 10.1016/j.amjcard.2023.03.016 [doi]
AB  - Although the echocardiographic:derived ratio of tricuspid annular plane systolic 
      excursion (TAPSE) to pulmonary arterial systolic pressure (PASP) is an important 
      prognostic tool in heart failure (HF), the relation with 6-minute walk distance 
      (6MWD) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) is less 
      established. We sought to establish the normative values of TAPSE:PASP among 
      older adults without cardiovascular disease (CVD) and evaluate the relation with 
      NT-proBNP and 6MWD. Among 1,542 participants of the Multi-Ethnic Study of 
      Atherosclerosis-HF ancillary study, the cross-sectional association of TAPSE:PASP 
      with the outcomes of 6MWD and NT-proBNP was analyzed using multivariable linear 
      regression, with progressive adjustment for sociodemographic and CVD risk 
      factors. Our cohort had a mean age (SD) of 73 +/- 8 years, 55% women, and a mean 
      TAPSE:PASP ratio of 0.68 +/- 0.16. In the unadjusted analysis, increasing tertiles 
      of TAPSE:PASP were associated with younger age, less diabetes, higher estimated 
      glomerular filtration rate, and less antihypertensive medication use. The 
      TAPSE:PASP ratio significantly correlated with both 6MWD and NT-proBNP in the 
      fully adjusted models. A 1-unit increment in TAPSE:PASP was associated with an 
      adjusted 9.9% (4.8% to 15.2%) higher 6MWD, whereas a 1-unit increment in 
      TAPSE:PASP was associated with an adjusted 38.0% (16.0% to 54.2%) lower 
      NT-proBNP. There was a significant gender interaction of the association of 
      TAPSE:PASP ratio and 6MWD, with stronger association seen in women. Among 
      multiethnic older adults free of clinical CVD, the TAPSE:PASP ratio decreased 
      with age, especially in women and was associated with decreased 6MWD and 
      increasing NT-proBNP, the markers of subclinical HF.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Mukherjee, Monica
AU  - Mukherjee M
AD  - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland. Electronic address: mmukher2@jhu.edu.
FAU - Ogunmoroti, Oluseye
AU  - Ogunmoroti O
AD  - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland.
FAU - Jani, Vivek
AU  - Jani V
AD  - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland.
FAU - Kapoor, Karan
AU  - Kapoor K
AD  - Division of Cardiology, Temple University School of Medicine, Philadelphia, 
      Pennsylvania.
FAU - Beussink-Nelson, Lauren
AU  - Beussink-Nelson L
AD  - Division of Cardiology, Northwestern University Feinberg School of Medicine, 
      Chicago, Illinois.
FAU - Freed, Benjamin H
AU  - Freed BH
AD  - Division of Cardiology, Northwestern University Feinberg School of Medicine, 
      Chicago, Illinois.
FAU - Hays, Allison G
AU  - Hays AG
AD  - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland.
FAU - Shah, Sanjiv J
AU  - Shah SJ
AD  - Division of Cardiology, Northwestern University Feinberg School of Medicine, 
      Chicago, Illinois.
FAU - Michos, Erin D
AU  - Michos ED
AD  - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland.
LA  - eng
GR  - N01HC95169/HL/NHLBI NIH HHS/United States
GR  - 75N92020D00007/HL/NHLBI NIH HHS/United States
GR  - T32 GM136577/GM/NIGMS NIH HHS/United States
GR  - R01 HL127028/HL/NHLBI NIH HHS/United States
GR  - R01 HL162851/HL/NHLBI NIH HHS/United States
GR  - N01HC95165/HL/NHLBI NIH HHS/United States
GR  - N01HC95167/HL/NHLBI NIH HHS/United States
GR  - N01HC95163/HL/NHLBI NIH HHS/United States
GR  - N01HC95160/HL/NHLBI NIH HHS/United States
GR  - R01 HL075476/HL/NHLBI NIH HHS/United States
GR  - 11SDG5200004/AHA/American Heart Association-American Stroke Association/United 
      States
GR  - R01 HL077612/HL/NHLBI NIH HHS/United States
GR  - N01HC95161/HL/NHLBI NIH HHS/United States
GR  - 75N92020D00001/HL/NHLBI NIH HHS/United States
GR  - R01 HL140731/HL/NHLBI NIH HHS/United States
GR  - R01 HL159715/HL/NHLBI NIH HHS/United States
GR  - 75N92020D00005/HL/NHLBI NIH HHS/United States
GR  - R01 HL098433/HL/NHLBI NIH HHS/United States
GR  - N01HC95168/HL/NHLBI NIH HHS/United States
GR  - 75N92020D00004/HL/NHLBI NIH HHS/United States
GR  - UL1 TR001420/TR/NCATS NIH HHS/United States
GR  - R01 HL107577/HL/NHLBI NIH HHS/United States
GR  - N01HC95159/HL/NHLBI NIH HHS/United States
GR  - 75N92020D00002/HL/NHLBI NIH HHS/United States
GR  - R01 HL149423/HL/NHLBI NIH HHS/United States
GR  - HHSN268201500003I/HL/NHLBI NIH HHS/United States
GR  - N01HC95164/HL/NHLBI NIH HHS/United States
GR  - R01 HL147660/HL/NHLBI NIH HHS/United States
GR  - U54 HL160273/HL/NHLBI NIH HHS/United States
GR  - UL1 TR001079/TR/NCATS NIH HHS/United States
GR  - N01HC95166/HL/NHLBI NIH HHS/United States
GR  - R01 HL086719/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000040/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230415
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
CIN - Am J Cardiol. 2023 Jun 15;197:84-86. PMID: 37121823
MH  - Humans
MH  - Female
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - Male
MH  - *Hypertension, Pulmonary
MH  - Cross-Sectional Studies
MH  - Functional Status
MH  - Echocardiography, Doppler
MH  - Prospective Studies
MH  - *Heart Failure
MH  - Ventricular Function, Right
MH  - *Ventricular Dysfunction, Right
PMC - PMC10164695
MID - NIHMS1886878
COIS- Disclosures Unrelated to this work, Dr. Michos served on a Medical Advisory Board 
      for Novartis, Novo Nordisk, Bayer, Boehringer Ingelheim, Esperion, Amarin, and 
      Astra Zeneca. Unrelated to this work, Dr. Shah receives consulting fees from 
      Abbott, Actelion, AstraZeneca, Amgen, Axon Therapeutics, Bayer, Boehringer 
      Ingelheim, Bristol Myers Squibb, Cardiora, CVRx, Cytokinetics, Eisai, 
      Glaxo-SmithKline, Ionis, Ironwood, Lilly, Merck, MyoKardia, Novartis, Novo 
      Nordisk, Pfizer, Regeneron, Sanofi, Shifamed, Tenax, and United Therapeutics. The 
      remaining authors have no conflicts of interest to declare.
EDAT- 2023/04/18 06:00
MHDA- 2023/05/08 06:42
PMCR- 2024/06/01
CRDT- 2023/04/17 18:02
PHST- 2022/08/17 00:00 [received]
PHST- 2023/03/01 00:00 [revised]
PHST- 2023/03/17 00:00 [accepted]
PHST- 2024/06/01 00:00 [pmc-release]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/04/18 06:00 [pubmed]
PHST- 2023/04/17 18:02 [entrez]
AID - S0002-9149(23)00156-X [pii]
AID - 10.1016/j.amjcard.2023.03.016 [doi]
PST - ppublish
SO  - Am J Cardiol. 2023 Jun 1;196:41-51. doi: 10.1016/j.amjcard.2023.03.016. Epub 2023 
      Apr 15.