PMID- 37068687
OWN - NLM
STAT- MEDLINE
DCOM- 20230601
LR  - 20230601
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 881
DP  - 2023 Jul 10
TI  - Chemical prioritization of pharmaceuticals and personal care products in an urban 
      tributary of the Potomac River.
PG  - 163514
LID - S0048-9697(23)02133-2 [pii]
LID - 10.1016/j.scitotenv.2023.163514 [doi]
AB  - Pharmaceuticals and personal care products (PPCPs) are incredibly diverse in 
      terms of chemical structures, physicochemical properties, and modes of action, 
      making their environmental impacts challenging to assess. New chemical 
      prioritization methodologies have emerged that compare contaminant monitoring 
      concentrations to multiple toxicity data sources, including whole organism and 
      high-throughput data, to develop a list of "high priority" chemicals requiring 
      further study. We applied such an approach to assess PPCPs in Hunting Creek, an 
      urban tributary of the Potomac River near Washington, DC, which has experienced 
      extensive human population growth. We estimated potential risks of 99 PPCPs from 
      surface water and sediment collected upstream and downstream of a major 
      wastewater treatment plant (WWTP), nearby combined sewer overflows (CSO), and in 
      the adjacent Potomac River. The greatest potential risks to the aquatic ecosystem 
      occurred near WWTP and CSO outfalls, but risk levels rapidly dropped below 
      thresholds of concern - established by previous chemical prioritization studies - 
      in the Potomac mainstem. These results suggest that urban tributaries, rather 
      than larger rivers, are important to monitor because their lower or intermittent 
      flow may not adequately dilute contaminants of concern. Common psychotropics, 
      such as fluoxetine and venlafaxine, presented the highest potential risks, with 
      toxicity quotients often > 10 in surface water and > 1000 in sediment, indicating 
      the need for further field studies. Several ubiquitous chemicals such as caffeine 
      and carbamazepine also exceeded thresholds of concern throughout our study area 
      and point to specific neurotoxic and endocrine modes of action that warrant 
      further investigation. Since many "high priority" chemicals in our analysis have 
      also triggered concerns in other areas around the world, better coordination is 
      needed among environmental monitoring programs to improve global chemical 
      prioritization efforts.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Hawkins, Cheyenne
AU  - Hawkins C
AD  - George Mason University, Department of Environmental Science and Policy, Fairfax, 
      VA, USA.
FAU - Foster, Gregory
AU  - Foster G
AD  - George Mason University, Department of Chemistry and Biochemistry, Fairfax, VA, 
      USA.
FAU - Glaberman, Scott
AU  - Glaberman S
AD  - George Mason University, Department of Environmental Science and Policy, Fairfax, 
      VA, USA. Electronic address: sglaberm@gmu.edu.
LA  - eng
PT  - Journal Article
DEP - 20230415
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Water Pollutants, Chemical)
RN  - 0 (Cosmetics)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Humans
MH  - Ecosystem
MH  - *Water Pollutants, Chemical/analysis
MH  - Environmental Monitoring/methods
MH  - *Cosmetics/analysis
MH  - Pharmaceutical Preparations
OTO - NOTNLM
OT  - Chemical prioritization
OT  - Contaminants of emerging concern
OT  - Endocrine disruption
OT  - Micropollutants
OT  - Risk assessment
OT  - Wastewater treatment
COIS- Declaration of competing interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Scott Glaberman reports financial support was provided by Alexandria 
      Renew Enterprises. Scott Glaberman reports financial support was provided by DC 
      Water Resources Research Institute.
EDAT- 2023/04/18 06:00
MHDA- 2023/06/01 06:42
CRDT- 2023/04/17 19:24
PHST- 2022/12/16 00:00 [received]
PHST- 2023/04/10 00:00 [revised]
PHST- 2023/04/11 00:00 [accepted]
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/04/18 06:00 [pubmed]
PHST- 2023/04/17 19:24 [entrez]
AID - S0048-9697(23)02133-2 [pii]
AID - 10.1016/j.scitotenv.2023.163514 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Jul 10;881:163514. doi: 10.1016/j.scitotenv.2023.163514. 
      Epub 2023 Apr 15.