PMID- 37069680
OWN - NLM
STAT- MEDLINE
DCOM- 20230419
LR  - 20240403
IS  - 1743-8977 (Electronic)
IS  - 1743-8977 (Linking)
VI  - 20
IP  - 1
DP  - 2023 Apr 17
TI  - Maternal exposure to ultrafine particles enhances influenza infection during 
      pregnancy.
PG  - 11
LID - 10.1186/s12989-023-00521-1 [doi]
LID - 11
AB  - BACKGROUND: Interactions between air pollution and infectious agents are 
      increasingly recognized and critical to identify, especially to protect 
      vulnerable populations. Pregnancy represents a vulnerable period for influenza 
      infection and air pollution exposure, yet interactions during pregnancy remain 
      unclear. Maternal exposure to ultrafine particles (UFPs, [Formula: see text] 
      100 nm diameter), a class of particulate matter ubiquitous in urban environments, 
      elicits unique pulmonary immune responses. We hypothesized that UFP exposure 
      during pregnancy would lead to aberrant immune responses to influenza enhancing 
      infection severity. RESULTS: Building from our well-characterized C57Bl/6N mouse 
      model employing daily gestational UFP exposure from gestational day (GD) 
      0.5-13.5, we carried out a pilot study wherein pregnant dams were subsequently 
      infected with Influenza A/Puerto Rico/8/1934 (PR8) on GD14.5. Findings indicate 
      that PR8 infection caused decreased weight gain in filtered air (FA) and 
      UFP-exposed groups. Co-exposure to UFPs and viral infection led to pronounced 
      elevation in PR8 viral titer and reduced pulmonary inflammation, signifying 
      potential suppression of innate and adaptive immune defenses. Pulmonary 
      expression of the pro-viral factor sphingosine kinase 1 (Sphk1) and 
      pro-inflammatory cytokine interleukin-1beta (IL-1 [Formula: see text]) was 
      significantly increased in pregnant mice exposed to UFPs and infected with PR8; 
      expression correlated with higher viral titer. CONCLUSIONS: Results from our 
      model provide initial insight into how maternal UFP exposure during pregnancy 
      enhances respiratory viral infection risk. This model is an important first step 
      in establishing future regulatory and clinical strategies for protecting pregnant 
      women exposed to UFPs.
CI  - (c) 2023. The Author(s).
FAU - Drury, Nicholas L
AU  - Drury NL
AD  - Department of Environmental and Occupational Health, Texas A&M University, 212 
      Adriance Lab Rd, 1266 TAMU, College Station, TX, 77843, USA.
AD  - Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.
FAU - Mustapha, Toriq
AU  - Mustapha T
AD  - Department of Environmental and Occupational Health, Texas A&M University, 212 
      Adriance Lab Rd, 1266 TAMU, College Station, TX, 77843, USA.
FAU - Shore, Ross A
AU  - Shore RA
AD  - Department of Environmental and Occupational Health, Texas A&M University, 212 
      Adriance Lab Rd, 1266 TAMU, College Station, TX, 77843, USA.
FAU - Zhao, Jiayun
AU  - Zhao J
AD  - Department of Chemistry, Texas A&M University, College Station, TX, 77843, USA.
FAU - Wright, Gus A
AU  - Wright GA
AD  - Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, 
      77843, USA.
FAU - Hoffmann, Aline Rodrigues
AU  - Hoffmann AR
AD  - Department of Comparative, Diagnostic, and Population Medicine, University of 
      Florida, Gainesville, FL, 32653, USA.
FAU - Talcott, Susanne U
AU  - Talcott SU
AD  - Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.
FAU - Regan, Annette
AU  - Regan A
AD  - School of Nursing and Health Professions, University of San Francisco, Orange 
      County, CA, 92868, USA.
FAU - Tighe, Robert M
AU  - Tighe RM
AD  - Department of Medicine, Duke University, Durham, NC, 27710, USA.
FAU - Zhang, Renyi
AU  - Zhang R
AD  - Department of Chemistry, Texas A&M University, College Station, TX, 77843, USA.
AD  - Department of Atmospheric Sciences, Texas A&M University, College Station, TX, 
      77843, USA.
FAU - Johnson, Natalie M
AU  - Johnson NM
AD  - Department of Environmental and Occupational Health, Texas A&M University, 212 
      Adriance Lab Rd, 1266 TAMU, College Station, TX, 77843, USA. nmjohnson@tamu.edu.
LA  - eng
GR  - R01 ES028866/ES/NIEHS NIH HHS/United States
GR  - T32 ES026568/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230417
PL  - England
TA  - Part Fibre Toxicol
JT  - Particle and fibre toxicology
JID - 101236354
RN  - 0 (Particulate Matter)
RN  - 0 (Air Pollutants)
SB  - IM
MH  - Female
MH  - Humans
MH  - Animals
MH  - Mice
MH  - Pregnancy
MH  - Particulate Matter/toxicity
MH  - *Influenza, Human
MH  - Maternal Exposure/adverse effects
MH  - Pilot Projects
MH  - Lung
MH  - *Air Pollutants/toxicity/analysis
MH  - Particle Size
PMC - PMC10106898
OTO - NOTNLM
OT  - Air pollution
OT  - Infection
OT  - Influenza
OT  - Mouse model
OT  - Particulate matter
OT  - Pregnancy
OT  - Ultrafine particles
COIS- Authors declare that they have no competing interests.
EDAT- 2023/04/19 06:00
MHDA- 2023/04/19 06:41
PMCR- 2023/04/17
CRDT- 2023/04/18 00:13
PHST- 2022/12/20 00:00 [received]
PHST- 2023/04/01 00:00 [accepted]
PHST- 2023/04/19 06:41 [medline]
PHST- 2023/04/18 00:13 [entrez]
PHST- 2023/04/19 06:00 [pubmed]
PHST- 2023/04/17 00:00 [pmc-release]
AID - 10.1186/s12989-023-00521-1 [pii]
AID - 521 [pii]
AID - 10.1186/s12989-023-00521-1 [doi]
PST - epublish
SO  - Part Fibre Toxicol. 2023 Apr 17;20(1):11. doi: 10.1186/s12989-023-00521-1.