PMID- 37070889
OWN - NLM
STAT- MEDLINE
DCOM- 20230420
LR  - 20230504
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 27
IP  - 7
DP  - 2023 Apr
TI  - Urine phthalate levels were associated with skin barrier dysfunction and atopic 
      sensitization in children.
PG  - 2888-2898
LID - 31920 [pii]
LID - 10.26355/eurrev_202304_31920 [doi]
AB  - OBJECTIVE: Phthalates can cause immunological disorders and aggravate allergic 
      diseases. Thus, we investigated the relationship between urinary phthalate, skin 
      barrier function, and atopic sensitization in children. PATIENTS AND METHODS: In 
      total, 448 school children [334 with severe allergic disease; and 123 with severe 
      atopic dermatitis (AD)] aged 10-12 years were enrolled in this study between June 
      and July 2017. Four high-molecular-weight phthalates (HMWP) [Sigma4HMWP] and three 
      low-molecular-weight phthalates (LMWP) [Sigma3LMWP] metabolites in urine samples, 
      specific immunoglobulin E (IgE), and total eosinophil count were measured. 
      Four-part trans epidermal water loss (TEWL) (cheek, leg, and upper/lower arm; 
      Sigma4TEWL) was measured to evaluate the skin barrier function. RESULTS: After 
      adjusting for confounding variables, Sigma4TEWL was significantly associated with the 
      quartiles of urinary Sigma4HMWP [adjusted beta=7.897, 95% confidence interval (CI): 
      0.636-15.158, p=0.033] and Sigma3LMWP (adjusted beta=9.670, 95% CI: 2.422-16.919, 
      p=0.009). The adjusted analyses revealed that the quartiles of urinary Sigma4HMWP and 
      Sigma3LMWP were not significantly associated with total eosinophil count, atopic 
      sensitization, and severe AD (p>0.05). According to the quartiles of urinary 
      Sigma4HMWP and Sigma3LMWP, there were significant differences in the TEWL of the lower 
      arm and leg (p<0.05) but not in cheek and upper arm. CONCLUSIONS: Exposure to 
      HMWPs and LMWPs was significantly associated with skin barrier dysfunction but 
      not with atopic sensitization. These results suggest that children exposed to 
      phthalates may be more susceptible to fragile skin barrier function.
FAU - Sung, M
AU  - Sung M
AD  - Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, Republic 
      of Korea. drmesh@gmail.com.
FAU - Kim, D H
AU  - Kim DH
FAU - Jee, H M
AU  - Jee HM
FAU - Kim, J H
AU  - Kim JH
FAU - Ha, E K
AU  - Ha EK
FAU - Shin, Y H
AU  - Shin YH
FAU - Han, M Y
AU  - Han MY
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 6O7F7IX66E (phthalic acid)
RN  - 0 (Phthalic Acids)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Child
MH  - *Dermatitis, Atopic/chemically induced
MH  - *Phthalic Acids/urine
MH  - *Hypersensitivity
MH  - Immunoglobulin E
EDAT- 2023/04/19 06:00
MHDA- 2023/04/20 06:42
CRDT- 2023/04/18 09:23
PHST- 2023/04/20 06:42 [medline]
PHST- 2023/04/18 09:23 [entrez]
PHST- 2023/04/19 06:00 [pubmed]
AID - 31920 [pii]
AID - 10.26355/eurrev_202304_31920 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):2888-2898. doi: 
      10.26355/eurrev_202304_31920.