PMID- 37070907
OWN - NLM
STAT- MEDLINE
DCOM- 20230420
LR  - 20230504
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 27
IP  - 7
DP  - 2023 Apr
TI  - New York Heart Association class and pulmonary artery pressure as prognostic 
      factors of interstitial lung disease survival.
PG  - 3045-3052
LID - 31938 [pii]
LID - 10.26355/eurrev_202304_31938 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate New York Heart Association 
      (NYHA) class and systolic pulmonary artery pressure (sPAP) as survival predictors 
      in major interstitial lung diseases (ILD) including idiopathic pulmonary fibrosis 
      (IPF), non-specific interstitial pneumonia (NSIP) and hypersensitivity 
      pneumonitis (HP) and in other ILD like granulomatosis with polyangiitis (GPA). 
      PATIENTS AND METHODS: We analyzed survival, NYHA class, sPAP, and Octreoscan 
      uptake index (UI) in 104 ILD patients (59 IPF, 19 NSIP, 10 HP and 16 GPA; median 
      age 60.5 years) all referred to a single centre. RESULTS: Median survival was 68 
      months, with 1- and 2-year survival of 91% and 78%, respectively. Survival was 
      lower among IPF and NSIP vs. HP and GPA patients (p=0.01). NYHA class 3-4 was 
      more frequent among IPF (76.3%) vs. NSIP patients (31.6%; p<0.001). HP and GPA 
      had NYHA class 1-2. NYHA class was negatively associated with survival (class 
      1=90.3 months vs. class 3=18.3 months and class 4=5.1 months; p=0.001). sPAP was 
      >55 mmHg in 76.3% of patients with IPF and 35-55 mmHg in 63.2% of patients with 
      NSIP. Patients with HP and GPA had sPAP < 55 mmHg. Among patients with IPF, NYHA 
      and sPAP were negatively associated with survival (p<0.01) both showed a parallel 
      trend. High-resolution computed tomography and survival were worse among IPF and 
      NSIP vs. HP and GPA patients (p<0.001). Octreoscan UI was <10, 10-12, and >12 in 
      IPF, NSIP, HP and GPA, respectively. Octreoscan UI was negatively associated with 
      survival (p=0.002). CONCLUSIONS: NYHA class and sPAP are comparable ILD survival 
      predictors. NYHA class is correlated with worse prognosis for IPF and NSIP vs. HP 
      and GPA patients.
FAU - Carbone, R G
AU  - Carbone RG
AD  - Department of Internal Medicine, University of Genoa, Genoa, Italy. 
      puppof@unige.it.
FAU - Monselise, A
AU  - Monselise A
FAU - Filiberti, R A
AU  - Filiberti RA
FAU - Penna, D
AU  - Penna D
FAU - Negrini, S
AU  - Negrini S
FAU - Puppo, F
AU  - Puppo F
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Prognosis
MH  - New York
MH  - Pulmonary Artery
MH  - *Lung Diseases, Interstitial/diagnosis
MH  - *Idiopathic Pulmonary Fibrosis
MH  - *Idiopathic Interstitial Pneumonias
MH  - Lung
EDAT- 2023/04/19 06:00
MHDA- 2023/04/20 10:17
CRDT- 2023/04/18 09:23
PHST- 2023/04/20 10:17 [medline]
PHST- 2023/04/18 09:23 [entrez]
PHST- 2023/04/19 06:00 [pubmed]
AID - 31938 [pii]
AID - 10.26355/eurrev_202304_31938 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):3045-3052. doi: 
      10.26355/eurrev_202304_31938.