PMID- 37071129
OWN - NLM
STAT- MEDLINE
DCOM- 20230802
LR  - 20230802
IS  - 1557-3125 (Electronic)
IS  - 1541-7786 (Linking)
VI  - 21
IP  - 8
DP  - 2023 Aug 1
TI  - Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell 
      Proliferation.
PG  - 825-835
LID - 10.1158/1541-7786.MCR-22-0814 [doi]
AB  - Cancer cells frequently alter their metabolism to support biogenesis and 
      proliferation and survive specific metabolic stressors. The glucose-associated 
      pentose phosphate pathway (PPP) is crucial for cancer cell proliferation. In 
      particular, 6-phosphogluconate dehydrogenase (6PGD), the second dehydrogenase in 
      the PPP, catalyzes the decarboxylation of 6-phosphogluconate into ribulose 
      5-phosphate (Ru5P). However, the mechanisms controlling 6PGD expression in cancer 
      cells remain unclear. Herein, we show that TAp73 increases Ru5P and NADPH 
      production through 6PGD activation to counteract reactive oxygen species and 
      protects cells from apoptosis. Moreover, 6PGD overexpression rescues the 
      proliferation and tumorigenic ability of TAp73-deficient cells. These findings 
      further establish the critical role of TAp73 on glucose metabolism regulation, 
      demonstrating that TAp73 can activate 6PGD expression to support oncogenic cell 
      growth. IMPLICATIONS: By transcriptional upregulation of 6PGD, TAp73 promotes the 
      generation of Ru5P and NADPH, and enhances tumor cell proliferation.
CI  - (c)2023 American Association for Cancer Research.
FAU - Qiao, Rui
AU  - Qiao R
AUID- ORCID: 0009-0000-9483-4871
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Wei, Mengmeng
AU  - Wei M
AUID- ORCID: 0000-0002-7354-8304
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Chen, Hui
AU  - Chen H
AUID- ORCID: 0009-0005-5767-0501
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Zhang, Xianhong
AU  - Zhang X
AUID- ORCID: 0000-0002-8574-4951
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Zhang, Jie
AU  - Zhang J
AUID- ORCID: 0009-0009-8135-6917
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Gao, Liyang
AU  - Gao L
AUID- ORCID: 0000-0002-1362-6403
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Ma, Haijun
AU  - Ma H
AUID- ORCID: 0009-0007-1247-6670
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Wang, Yujiong
AU  - Wang Y
AUID- ORCID: 0000-0003-2522-3043
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
FAU - Li, Le
AU  - Li L
AUID- ORCID: 0000-0003-3849-4854
AD  - School of Life Sciences, Ningxia University, Yinchuan, China.
AD  - Key Lab of Ministry of Education for Protection and Utilization of Special 
      Biological Resources in Western China, Yinchuan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cancer Res
JT  - Molecular cancer research : MCR
JID - 101150042
RN  - EC 1.1.1.43 (Phosphogluconate Dehydrogenase)
RN  - 53-59-8 (NADP)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Humans
MH  - *Phosphogluconate Dehydrogenase/genetics/metabolism
MH  - NADP/metabolism
MH  - *Neoplasms/pathology
MH  - Cell Proliferation
MH  - Reactive Oxygen Species/metabolism
MH  - Pentose Phosphate Pathway
EDAT- 2023/04/19 06:00
MHDA- 2023/08/02 06:42
CRDT- 2023/04/18 11:13
PHST- 2022/10/15 00:00 [received]
PHST- 2023/02/21 00:00 [revised]
PHST- 2023/04/14 00:00 [accepted]
PHST- 2023/08/02 06:42 [medline]
PHST- 2023/04/19 06:00 [pubmed]
PHST- 2023/04/18 11:13 [entrez]
AID - 725940 [pii]
AID - 10.1158/1541-7786.MCR-22-0814 [doi]
PST - ppublish
SO  - Mol Cancer Res. 2023 Aug 1;21(8):825-835. doi: 10.1158/1541-7786.MCR-22-0814.