PMID- 37072327
OWN - NLM
STAT- MEDLINE
DCOM- 20230420
LR  - 20230420
IS  - 1608-3040 (Electronic)
IS  - 0006-2979 (Linking)
VI  - 88
IP  - 2
DP  - 2023 Feb
TI  - Imbalance of Angiogenic and Growth Factors in Placenta in Maternal 
      Hyperhomocysteinemia.
PG  - 262-279
LID - 10.1134/S0006297923020098 [doi]
AB  - Numerous studies have shown that various adverse factors of different nature and 
      action mechanisms have similar negative influence on placental angiogenesis, 
      resulting in insufficiency of placental blood supply. One of the risk factors for 
      pregnancy complications with placental etiology is an increased level of 
      homocysteine in the blood of pregnant women. However, the effect of 
      hyperhomocysteinemia (HHcy) on the development of the placenta and, in 
      particular, on the formation of its vascular network is at present poorly 
      understood. The aim of this work was to study the effect of maternal HHcy on the 
      expression of angiogenic and growth factors (VEGF-A, MMP-2, VEGF-B, BDNF, NGF), 
      as well as their receptors (VEGFR-2, TrkB, p75NTR), in the rat placenta. The 
      effects of HHcy were studied in the morphologically and functionally different 
      maternal and fetal parts of the placenta on the 14th and 20th day of pregnancy. 
      The maternal HHcy caused increase in the levels of oxidative stress and apoptosis 
      markers accompanied by an imbalance of the studied angiogenic and growth factors 
      in the maternal and/or fetal part of the placenta. The influence of maternal HHcy 
      in most cases manifested in a decrease in the protein content (VEGF-A), enzymatic 
      activity (MMP-2), gene expression (VEGFB, NGF, TRKB), and accumulation of 
      precursor form (proBDNF) of the investigated factors. In some cases, the effects 
      of HHcy differed depending on the placental part and stage of development. The 
      influence of maternal HHcy on signaling pathways and processes controlled by the 
      studied angiogenic and growth factors could lead to incomplete development of the 
      placental vasculature and decrease in the placental transport, resulting in fetal 
      growth restriction and impaired fetal brain development.
FAU - Arutjunyan, Alexander V
AU  - Arutjunyan AV
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia. alexarutiunjan@gmail.com.
FAU - Kerkeshko, Gleb O
AU  - Kerkeshko GO
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
FAU - Milyutina, Yulia P
AU  - Milyutina YP
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
AD  - St. Petersburg State Pediatric Medical University, Russian Ministry of Health, 
      St. Petersburg, 194100, Russia.
FAU - Shcherbitskaia, Anastasiia D
AU  - Shcherbitskaia AD
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
AD  - I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian 
      Academy of Sciences, St. Petersburg, 194223, Russia.
FAU - Zalozniaia, Irina V
AU  - Zalozniaia IV
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
FAU - Mikhel, Anastasiia V
AU  - Mikhel AV
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
FAU - Inozemtseva, Daria B
AU  - Inozemtseva DB
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
FAU - Vasilev, Dmitrii S
AU  - Vasilev DS
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
AD  - I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian 
      Academy of Sciences, St. Petersburg, 194223, Russia.
FAU - Kovalenko, Anna A
AU  - Kovalenko AA
AD  - I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian 
      Academy of Sciences, St. Petersburg, 194223, Russia.
FAU - Kogan, Igor Yu
AU  - Kogan IY
AD  - D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 
      St. Petersburg, 199034, Russia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochemistry (Mosc)
JT  - Biochemistry. Biokhimiia
JID - 0376536
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Rats
MH  - Humans
MH  - Animals
MH  - *Placenta/metabolism
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - *Hyperhomocysteinemia/metabolism
MH  - Nerve Growth Factor/metabolism/pharmacology
OTO - NOTNLM
OT  - angiogenic factors
OT  - maternal hyperhomocysteinemia
OT  - neurotrophins
OT  - placenta
EDAT- 2023/04/19 00:42
MHDA- 2023/04/20 06:42
CRDT- 2023/04/18 22:13
PHST- 2023/04/20 06:42 [medline]
PHST- 2023/04/19 00:42 [pubmed]
PHST- 2023/04/18 22:13 [entrez]
AID - BCM88020243 [pii]
AID - 10.1134/S0006297923020098 [doi]
PST - ppublish
SO  - Biochemistry (Mosc). 2023 Feb;88(2):262-279. doi: 10.1134/S0006297923020098.