PMID- 37072640
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 479
IP  - 2
DP  - 2024 Feb
TI  - Effect of RNA-binding proteins on osteogenic differentiation of bone marrow 
      mesenchymal stem cells.
PG  - 383-392
LID - 10.1007/s11010-023-04742-y [doi]
AB  - Tissue regeneration mediated by mesenchymal stem cells (MSCs) is an ideal way to 
      repair bone defects. RNA-binding proteins (RBPs) can affect cell function through 
      post-transcriptional regulation. Exploring the role of RBPs in the process of 
      osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is 
      helpful to find a key method to promote the osteogenic efficiency of BMSCs. By 
      reviewing the literature, we obtained a differentially expressed mRNA dataset 
      during the osteogenic differentiation of BMSCs and a human RBP dataset. A total 
      of 82 differentially expressed RBPs in the osteogenic differentiation of BMSCs 
      were screened by intersection of the two datasets. Functional analysis showed 
      that the differentially expressed RBPs were mainly involved in RNA transcription, 
      translation and degradation through the formation of spliceosomes and 
      ribonucleoprotein complexes. The top 15 RBPs determined by degree score were FBL, 
      NOP58, DDX10, RPL9, SNRPD3, NCL, IFIH1, RPL18A, NAT10, EXOSC5, ALYREF, PA2G4, 
      EIF5B, SNRPD1 and EIF6. The results of this study demonstrate that the expression 
      of many RBPs changed during osteogenic differentiation of BMSCs.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Luo, Bin
AU  - Luo B
AD  - Department of Prosthodontics, School of Stomatology, Beijing Stomatological 
      Hospital, Capital Medical University, No. 4 Tiantan Xili, Beijing, 100050, China.
FAU - Jiang, Qingsong
AU  - Jiang Q
AUID- ORCID: 0000-0003-2553-1863
AD  - Department of Prosthodontics, School of Stomatology, Beijing Stomatological 
      Hospital, Capital Medical University, No. 4 Tiantan Xili, Beijing, 100050, China. 
      qsjiang@ccmu.edu.cn.
LA  - eng
GR  - YSP202207/Young Scientist Program of Beijing Stomatological Hospital, Capital 
      Medical University/
GR  - 82170980/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230419
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 63231-63-0 (RNA)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (EXOSC5 protein, human)
RN  - 0 (Antigens, Neoplasm)
RN  - EC 3.1.- (Exosome Multienzyme Ribonuclease Complex)
RN  - 0 (PA2G4 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - EC 3.6.1.- (DDX10 protein, human)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
SB  - IM
MH  - Humans
MH  - *Osteogenesis
MH  - Cell Differentiation
MH  - *Mesenchymal Stem Cells
MH  - RNA
MH  - RNA-Binding Proteins/genetics
MH  - Bone Marrow Cells
MH  - Cells, Cultured
MH  - Antigens, Neoplasm
MH  - Exosome Multienzyme Ribonuclease Complex
MH  - Adaptor Proteins, Signal Transducing
MH  - DEAD-box RNA Helicases
OTO - NOTNLM
OT  - Bone marrow mesenchymal stem cells
OT  - Osteogenic differentiation
OT  - RNA-binding proteins
OT  - Ribonucleoprotein complex
OT  - Spliceosome
EDAT- 2023/04/19 00:41
MHDA- 2024/02/26 06:44
CRDT- 2023/04/18 23:30
PHST- 2023/03/13 00:00 [received]
PHST- 2023/04/12 00:00 [accepted]
PHST- 2024/02/26 06:44 [medline]
PHST- 2023/04/19 00:41 [pubmed]
PHST- 2023/04/18 23:30 [entrez]
AID - 10.1007/s11010-023-04742-y [pii]
AID - 10.1007/s11010-023-04742-y [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2024 Feb;479(2):383-392. doi: 10.1007/s11010-023-04742-y. Epub 
      2023 Apr 19.