PMID- 37073221
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230421
IS  - 2662-1746 (Electronic)
IS  - 2096-6490 (Print)
IS  - 2662-1746 (Linking)
VI  - 4
IP  - 2
DP  - 2022 May
TI  - Hypolipidemic effect of chromium-modified enzymatic product of sulfated rhamnose 
      polysaccharide from Enteromorpha prolifera in type 2 diabetic mice.
PG  - 245-254
LID - 10.1007/s42995-022-00127-0 [doi]
AB  - Sulfated rhamnose polysaccharide (SRP) derived from Enteromorpha prolifera is a 
      metal-ion chelating agent that could potentially be used to treat diabetes. The 
      aim of our study was to determine the effect of a variant of SRP on DIABETES. 
      First, we synthesized and characterized SRPE-3 chromium(III) [SRPE-3-Cr(III)] 
      complex using an enzymatic method. The maximum chelation rate was 18.2% under 
      optimal chelating conditions of pH 6.0, time 4 h, and temperature 60  degrees C. Fourier 
      transform infrared spectroscopy results showed important sites for 
      Cr(III)-binding were O-H and C=O groups. We then studied the hypolipidemic 
      effects of SRPE-3-Cr(III) on type 2 diabetes mellitus (T2DM) induced by a 
      high-fat, high-sucrose diet (HFSD). Decreased blood glucose content, body fat 
      ratio, serum TG, TC, LDL-C, and increased serum HDL-C were observed after 
      treatment with SRPE-3-Cr(III). In addition, SRPE-3-Cr(III) significantly reduced 
      leptin, resistin, and TNF-alpha levels, and increased adiponectin contents relative 
      to T2DM. Histopathology results also showed that SRPE-3-Cr(III) could alleviate 
      the HFSD-lesioned tissues. SRPE-3-Cr(III) also improved lipid metabolism via a 
      reduction in aspartate aminotransferase, alanine aminotransferase, fatty acid 
      synthase, and acetyl-CoA carboxylase activities in the liver. SRPE-3-Cr(III) at 
      low doses exhibited better lipid-lowering activities, hence, could be considered 
      to be a novel compound to treat hyperlipidemia and also act as an anti-diabetic 
      agent.
CI  - (c) The Author(s) 2022.
FAU - Wang, Xinyu
AU  - Wang X
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao, 
      266003 China. GRID: grid.4422.0. ISNI: 0000 0001 2152 3263
FAU - Ye, Han
AU  - Ye H
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao, 
      266003 China. GRID: grid.4422.0. ISNI: 0000 0001 2152 3263
FAU - Cui, Jiefen
AU  - Cui J
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao, 
      266003 China. GRID: grid.4422.0. ISNI: 0000 0001 2152 3263
FAU - Chi, Yongzhou
AU  - Chi Y
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao, 
      266003 China. GRID: grid.4422.0. ISNI: 0000 0001 2152 3263
FAU - Liu, Ruizhi
AU  - Liu R
AD  - State Environmental Protection Key Laboratory of Estuarine and Coastal 
      Environment, Beijing, 100012 China.
FAU - Wang, Peng
AU  - Wang P
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao, 
      266003 China. GRID: grid.4422.0. ISNI: 0000 0001 2152 3263
LA  - eng
PT  - Journal Article
DEP - 20220405
PL  - Singapore
TA  - Mar Life Sci Technol
JT  - Marine life science & technology
JID - 101748793
PMC - PMC10077238
OTO - NOTNLM
OT  - Chromium
OT  - Enteromorpha prolifera
OT  - Hypolipidemic
OT  - Sulfated rhamnose polysaccharides
OT  - Type 2 diabetic mice
COIS- Conflict of interestsThe authors declare that they have no competing financial or 
      non-financial conflict of interests.
EDAT- 2023/04/19 06:41
MHDA- 2023/04/19 06:42
PMCR- 2022/04/05
CRDT- 2023/04/19 01:45
PHST- 2021/08/15 00:00 [received]
PHST- 2022/02/22 00:00 [accepted]
PHST- 2023/04/19 06:42 [medline]
PHST- 2023/04/19 06:41 [pubmed]
PHST- 2023/04/19 01:45 [entrez]
PHST- 2022/04/05 00:00 [pmc-release]
AID - 127 [pii]
AID - 10.1007/s42995-022-00127-0 [doi]
PST - epublish
SO  - Mar Life Sci Technol. 2022 Apr 5;4(2):245-254. doi: 10.1007/s42995-022-00127-0. 
      eCollection 2022 May.