PMID- 37073636
OWN - NLM
STAT- MEDLINE
DCOM- 20230420
LR  - 20230420
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 41
IP  - 4
DP  - 2023 Apr
TI  - Multicentre case-control study evaluating the safety of anti-SARS-CoV-2 vaccines 
      in a cohort of patients with systemic vasculitis.
PG  - 922-927
LID - 10.55563/clinexprheumatol/if8nka [doi]
AB  - OBJECTIVES: Data on the safety of anti-SARS-CoV-2 vaccines in patients with rare 
      rheumatic diseases, such as systemic vasculitis (SV), are limited. The aim of 
      this study was to evaluate the occurrence of a disease flare and the appearance 
      of adverse events (AEs) following administration of anti-SARS-CoV-2 vaccine in a 
      multicentre cohort of patients with SV. METHODS: Patients with SV and healthy 
      controls (HC) from two different Italian rheumatology centres were asked to 
      complete a questionnaire assessing disease flares occurrence, defined as new 
      onset of clinical manifestations related to vasculitis needing an implementation 
      of therapy, and local/systemic AEs appearance following anti SARS-CoV-2 
      vaccination. RESULTS: 107 patients with SV (57 ANCA-associated) and 107 HC were 
      enrolled. A disease flare occurred in only one patient (0.93%) with microscopic 
      polyangiitis after the first dose of an mRNA vaccine. After both the first and 
      the second vaccine dose administration, no significant differences in AEs between 
      patients with SV and HC were observed; no serious AEs were reported as well. 
      CONCLUSIONS: These data suggest a good risk profile for anti-SARS-CoV-2 vaccine 
      in patients with systemic vasculitis.
FAU - Simoncelli, Edoardo
AU  - Simoncelli E
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Conticini, Edoardo
AU  - Conticini E
AD  - Rheumatology Unit, Department of Medicine, Surgery and Neuroscience, University 
      of Siena, Italy.
FAU - Colafrancesco, Serena
AU  - Colafrancesco S
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Gattamelata, Angelica
AU  - Gattamelata A
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Spinelli, Francesca Romana
AU  - Spinelli FR
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Garufi, Cristina
AU  - Garufi C
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Truglia, Simona
AU  - Truglia S
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Grazzini, Silvia
AU  - Grazzini S
AD  - Rheumatology Unit, Department of Medicine, Surgery and Neuroscience, University 
      of Siena, Italy.
FAU - Giardina, Federico
AU  - Giardina F
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Izzo, Raffaella
AU  - Izzo R
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Cantarini, Luca
AU  - Cantarini L
AD  - Rheumatology Unit, Department of Medicine, Surgery and Neuroscience, University 
      of Siena, Italy.
FAU - Frediani, Bruno
AU  - Frediani B
AD  - Rheumatology Unit, Department of Medicine, Surgery and Neuroscience, University 
      of Siena, Italy.
FAU - Conti, Fabrizio
AU  - Conti F
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy. 
      fabrizio.conti@uniroma1.it.
FAU - Priori, Roberta
AU  - Priori R
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, and Saint Camillus 
      International University of Health and Medical Science, UniCamillus, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20230418
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (COVID-19 Vaccines)
SB  - IM
MH  - Humans
MH  - Case-Control Studies
MH  - *COVID-19/prevention & control
MH  - *COVID-19 Vaccines/adverse effects
MH  - *Microscopic Polyangiitis
MH  - Symptom Flare Up
MH  - *Systemic Vasculitis/etiology
MH  - Vaccination/adverse effects
EDAT- 2023/04/19 06:41
MHDA- 2023/04/20 10:17
CRDT- 2023/04/19 04:13
PHST- 2022/10/30 00:00 [received]
PHST- 2023/01/16 00:00 [accepted]
PHST- 2023/04/20 10:17 [medline]
PHST- 2023/04/19 06:41 [pubmed]
PHST- 2023/04/19 04:13 [entrez]
AID - 19332 [pii]
AID - 10.55563/clinexprheumatol/if8nka [doi]
PST - ppublish
SO  - Clin Exp Rheumatol. 2023 Apr;41(4):922-927. doi: 
      10.55563/clinexprheumatol/if8nka. Epub 2023 Apr 18.