PMID- 37074152
OWN - NLM
STAT- MEDLINE
DCOM- 20230616
LR  - 20230618
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 108
IP  - 6
DP  - 2023 Jun 9
TI  - Effect of a neurokinin 3 receptor-selective agonist administration on the embryos 
      recovered from superovulated cows.
PG  - 936-944
LID - 10.1093/biolre/ioad039 [doi]
AB  - Superovulation (SOV) treatment of cows results in unovulated follicles and 
      inconsistent quality of the recovered embryos. It has been demonstrated that 
      luteinizing hormone (LH) secretion is suppressed during SOV treatment of cows, 
      which may cause insufficient follicle development and variation in the 
      development of recovered embryos and unovulated follicles. Pulsatile 
      gonadotropin-releasing hormone/LH secretion is controlled by the activity of 
      kisspeptin, neurokinin B and dynorphin (KNDy) neurons in the arcuate nucleus in 
      many mammals. As neurokinin B promotes the activity of KNDy neurons, we 
      hypothesized that senktide, a neurokinin B receptor agonist, has the potential as 
      a therapeutic drug to improve the ovulation rate and quality of recovered embryos 
      in SOV-treated cows via stimulation of LH secretion. Senktide was administered 
      intravenously (30 or 300 nmol/min) for 2 h, beginning from 72 h after the start 
      of SOV treatment. LH secretion was examined before and after administration, and 
      embryos were collected 7 d after estrus. Senktide administration increased LH 
      secretion in SOV-treated cows. The ratios of code 1, code 1 and 2, and blastocyst 
      stage embryos to recovered embryos were increased by senktide (300 nmol/min) 
      administration. Moreover, the mRNA levels of MTCO1, COX7C, and MTATP6 were 
      upregulated in recovered embryos of senktide (300 nmol/min)-administered animals. 
      These results indicate that the administration of senktide to SOV-treated cows 
      enhances LH secretion and upregulates the expression of genes involved in 
      mitochondrial metabolism in embryos, thereby improving embryo development and 
      embryo quality.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of Society 
      for the Study of Reproduction. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Matsuyama, Shuichi
AU  - Matsuyama S
AD  - Division of Animal Feeding and Management Research, Institute of Livestock and 
      Grassland Science, NARO, Nasushiobara 329-2793, Japan.
AD  - Laboratory of Animal Production Science, Graduate School of Bioagricultural 
      Sciences, Nagoya University, Nagoya 470-0151, Japan.
FAU - Nakamura, Sho
AU  - Nakamura S
AD  - Division of Animal Feeding and Management Research, Institute of Livestock and 
      Grassland Science, NARO, Nasushiobara 329-2793, Japan.
AD  - Laboratory of Animal Production Science, Graduate School of Bioagricultural 
      Sciences, Nagoya University, Nagoya 470-0151, Japan.
FAU - Minabe, Shiori
AU  - Minabe S
AD  - Division of Animal Feeding and Management Research, Institute of Livestock and 
      Grassland Science, NARO, Nasushiobara 329-2793, Japan.
FAU - Ohkura, Satoshi
AU  - Ohkura S
AD  - Laboratory of Animal Production Science, Graduate School of Bioagricultural 
      Sciences, Nagoya University, Nagoya 470-0151, Japan.
FAU - Kimura, Koji
AU  - Kimura K
AD  - Laboratory of Reproductive Physiology, Graduate School of Environmental and Life 
      Science, Okayama University, Okayama 700-8530, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Receptors, Neurokinin-3)
RN  - 86933-75-7 (Neurokinin B)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 74913-18-1 (Dynorphins)
RN  - 0 (Kisspeptins)
SB  - IM
MH  - Female
MH  - Cattle
MH  - Animals
MH  - *Receptors, Neurokinin-3/agonists
MH  - *Neurokinin B/metabolism
MH  - Luteinizing Hormone/pharmacology/metabolism
MH  - Gonadotropin-Releasing Hormone/metabolism
MH  - Dynorphins/metabolism
MH  - Arcuate Nucleus of Hypothalamus/metabolism
MH  - Kisspeptins/metabolism
MH  - Mammals/metabolism
OTO - NOTNLM
OT  - NK3R
OT  - NKB
OT  - cow
OT  - embryonic quality
OT  - luteinizing hormone
OT  - superovulation
EDAT- 2023/04/19 12:42
MHDA- 2023/06/16 06:42
CRDT- 2023/04/19 09:54
PHST- 2022/10/26 00:00 [received]
PHST- 2023/03/03 00:00 [revised]
PHST- 2023/03/30 00:00 [accepted]
PHST- 2023/06/16 06:42 [medline]
PHST- 2023/04/19 12:42 [pubmed]
PHST- 2023/04/19 09:54 [entrez]
AID - 7130269 [pii]
AID - 10.1093/biolre/ioad039 [doi]
PST - ppublish
SO  - Biol Reprod. 2023 Jun 9;108(6):936-944. doi: 10.1093/biolre/ioad039.