PMID- 37074267
OWN - NLM
STAT- MEDLINE
DCOM- 20230421
LR  - 20230424
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 55
IP  - 1
DP  - 2023 Dec
TI  - The impact of baseline calcified plaque volume on coronary rapid plaque 
      progression by serial coronary computed tomography angiography in patients with 
      type 2 diabetes.
PG  - 2196438
LID - 10.1080/07853890.2023.2196438 [doi]
LID - 2196438
AB  - OBJECTIVES: Patients with type 2 diabetes mellitus (T2DM) are susceptible to 
      coronary artery disease (CAD), and coronary outcomes in these patients are 
      heterogeneous. However, the impact of coronary plaque compositions on rapid 
      plaque progression (RPP) in patients with T2DM has rarely been reported. This 
      study aimed to investigate the association of coronary plaque compositions with 
      rapid lesion volume progression in patients with T2DM. MATERIALS AND METHODS: A 
      total of 159 subjects (aged 62.51 +/- 10.3 years, 68.6% were male) who underwent 
      serial coronary computed tomography angiography (CCTA) with type 2 diabetic 
      status were enrolled. Annual change of plaque volume (PV) (mm(3)/year) was 
      defined as PV change divided by inter-scan period. RPP was defined as the 
      progression of plaque burden (PV divided by vessel volume multiplied by 100) 
      >/=0.59%/year. Plaque components were compared between RPP and no RPP groups. Then 
      all patients were divided into 3 groups according to the baseline calcified 
      plaque volume tertiles. The outcome was whether RPP occurred. RESULTS: The median 
      inter-scan period was 2.09 (range 1.41-3.33) years. The overall incidence of RPP 
      was 61.0%. The calcified plaque volume decreased significantly in the RPP group 
      as compared to the no RPP group. The risk of RPP (odds ratio [OR] 0.39; 95% 
      confidence interval [CI]: 0.17-0.88; p = 0.024) was reduced in tertiles III as 
      compared to that in tertiles I even after adjustment for baseline variables (OR 
      0.21; 95% CI: 0.07-0.63; p = 0.005). Moreover, adding the calcified plaque volume 
      significantly raised the predictive value for the RPP (0.370, p = 0.030, and 
      0.059, p = 0.025, NRI, and IDI respectively) as compared to traditional factors. 
      CONCLUSION: The baseline calcified plaque volume is an independent protective 
      factor for the rapid progression of coronary atherosclerosis in patients with 
      T2DM.
FAU - Jian, Zhijie
AU  - Jian Z
AD  - Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, P.R. China.
FAU - Yao, Guolin
AU  - Yao G
AD  - Department of Radiology, Xi'an Gao Xin Hospital, Xi'an, P.R. China.
FAU - Guo, Huafeng
AU  - Guo H
AD  - Department of Radiology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, 
      P.R. China.
FAU - Liu, Hui
AU  - Liu H
AD  - Biobank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. 
      China.
FAU - Li, Bolin
AU  - Li B
AD  - Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, P.R. China.
FAU - Yu, Bolang
AU  - Yu B
AD  - Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, P.R. China.
FAU - Yang, Jian
AU  - Yang J
AD  - Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, P.R. China.
FAU - Cheng, Lele
AU  - Cheng L
AD  - Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Computed Tomography Angiography/methods
MH  - Coronary Angiography
MH  - Disease Progression
MH  - Coronary Vessels/diagnostic imaging/pathology
MH  - *Plaque, Atherosclerotic/diagnostic imaging/pathology
MH  - *Coronary Artery Disease/diagnostic imaging/epidemiology/pathology
MH  - Predictive Value of Tests
PMC - PMC10120538
OAB - The calcified plaque volume of the coronary was significantly lower in T2DM 
      subjects with RPP than in those without RPP.Higher levels of atherosclerotic 
      calcification may have a protective value on plaque stabilization in patients 
      with T2DM.Calcified plaque volume of the coronary should be considered when 
      proposing risk stratification in T2DM patients.
OABL- eng
OTO - NOTNLM
OT  - Calcified plaque volume
OT  - coronary computed tomography angiography
OT  - diabetes
OT  - rapid plaque progression
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2023/04/19 12:42
MHDA- 2023/04/21 06:41
PMCR- 2023/04/19
CRDT- 2023/04/19 10:34
PHST- 2023/04/21 06:41 [medline]
PHST- 2023/04/19 12:42 [pubmed]
PHST- 2023/04/19 10:34 [entrez]
PHST- 2023/04/19 00:00 [pmc-release]
AID - 2196438 [pii]
AID - 10.1080/07853890.2023.2196438 [doi]
PST - ppublish
SO  - Ann Med. 2023 Dec;55(1):2196438. doi: 10.1080/07853890.2023.2196438.