PMID- 37075796
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230724
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Jul
TI  - Inflammatory Endotypes of Chronic Rhinosinusitis in the Korean Population: 
      Distinct Expression of Type 3 Inflammation.
PG  - 437-450
LID - 10.4168/aair.2023.15.4.437 [doi]
AB  - PURPOSE: Cluster analyses on inflammatory markers of chronic rhinosinusitis (CRS) 
      in Asians from multicenter data are lacking. This multicenter study aimed to 
      identify the endotypes of CRS in Koreans and to evaluate the relationship between 
      the endotypes and clinical parameters. METHODS: Nasal tissues were obtained from 
      patients with CRS and controls who underwent surgery. The endotypes of CRS were 
      investigated by measuring interleukin (IL)-5, interferon (IFN)-gamma, IL-17A, IL-22, 
      IL-1beta, IL-6, IL-8, matrix metalloproteinase-9, eotaxin-3, eosinophil cationic 
      protein, myeloperoxidase (MPO), human neutrophil elastase (HNE), periostin, 
      transforming growth factor-beta1, total immunoglobulin E (IgE), and staphylococcal 
      enterotoxin (SE)-specific IgE. We performed hierarchical cluster analysis and 
      evaluated the phenotype, comorbidities, and Lund-Mackay computed tomography (LM 
      CT) score in each cluster. RESULTS: Five clusters and 3 endotypes were extracted 
      from 244 CRS patients: cluster 1 had no upregulated mediators compared to the 
      other clusters (mild mixed inflammatory CRS); clusters 2, 3, and 4 had higher 
      concentrations of neutrophil-associated mediators including HNE, IL-8, IL-17A, 
      and MPO (T3 CRS); and cluster 5 had higher levels of eosinophil-associated 
      mediators (T2 CRS). SE-specific IgE was undetectable in T3 CRS and had low 
      detectable levels (6.2%) even in T2 CRS. The CRS with nasal polyps (CRSwNP) 
      phenotype and LM CT scores showed no significant differences between T2 and T3 
      CRS, while the incidence of comorbid asthma was higher in T2 CRS than T3 CRS. In 
      T3 clusters, higher levels of neutrophilic markers were associated with disease 
      severity and CRSwNP phenotype. CONCLUSIONS: In Koreans, there is a distinct T3 
      CRS endotype showing a high proportion of CRSwNP and severe disease extent, along 
      with T2 CRS.
CI  - Copyright (c) 2023 The Korean Academy of Asthma, Allergy and Clinical Immunology * 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Min, Jin-Young
AU  - Min JY
AUID- ORCID: 0000-0003-1890-2451
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Kyung Hee University 
      Hospital, Kyung Hee University College of Medicine, Seoul, Korea.
FAU - Kim, Jin Youp
AU  - Kim JY
AUID- ORCID: 0000-0003-2687-6919
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University Ilsan 
      Hospital, Goyang, Korea.
FAU - Sung, Chung Man
AU  - Sung CM
AUID- ORCID: 0000-0002-4686-9153
AD  - Department of Otolaryngology-Head and Neck Surgery, Chonnam National University 
      Hospital and Chonnam National University Medical School, Gwangju, Korea.
FAU - Kim, Seon Tae
AU  - Kim ST
AUID- ORCID: 0000-0002-2010-2843
AD  - Department of Otolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon 
      University College of Medicine, Incheon, Korea.
FAU - Cho, Hyun-Jin
AU  - Cho HJ
AUID- ORCID: 0000-0002-6518-351X
AD  - Department of Otorhinolaryngology, Gyeongsang National University Hospital and 
      Gyeongsang National University School of Medicine, Jinju, Korea.
FAU - Mun, Sue Jean
AU  - Mun SJ
AUID- ORCID: 0000-0003-4486-7178
AD  - Department of Otorhinolaryngology, Pusan National University Yangsan Hospital, 
      Busan, Korea.
FAU - Cho, Sung-Woo
AU  - Cho SW
AUID- ORCID: 0000-0003-0827-4471
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Bundang Hospital, Seoul National University College of Medicine, 
      Seongnam, Korea.
FAU - Hong, Sang Duk
AU  - Hong SD
AUID- ORCID: 0000-0003-3075-1035
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Ryu, Gwanghui
AU  - Ryu G
AUID- ORCID: 0000-0002-3251-399X
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Cho, Kyoung Rai
AU  - Cho KR
AUID- ORCID: 0000-0001-9633-8281
AD  - Departments of Otorhinolaryngology-Head and Neck Surgery, Sanggye Paik Hospital, 
      College of Medicine, Inje University, Seoul, Korea.
FAU - Kim, Young Hyo
AU  - Kim YH
AUID- ORCID: 0000-0002-3623-1770
AD  - Kimyounghyo ENT Clinic, Incheon, Korea.
FAU - Park, Soo Kyoung
AU  - Park SK
AUID- ORCID: 0000-0002-5163-536X
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National 
      University School of Medicine, Daejeon, Korea.
FAU - Kim, Dong-Kyu
AU  - Kim DK
AUID- ORCID: 0000-0003-4917-0177
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart 
      Hospital, Hallym University College of Medicine, Chuncheon, Korea.
FAU - Lee, Dong Hoon
AU  - Lee DH
AUID- ORCID: 0000-0001-9288-5368
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National 
      University Hwasun Hospital, Chonnam, Korea.
FAU - Heo, Sung Jae
AU  - Heo SJ
AUID- ORCID: 0000-0002-1388-8075
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, 
      Kyungpook National University, Daegu, Korea.
FAU - Lee, Ki-Il
AU  - Lee KI
AUID- ORCID: 0000-0002-2069-7912
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Konyang University 
      College of Medicine, Daejeon, Korea.
FAU - Kim, Su Jin
AU  - Kim SJ
AUID- ORCID: 0000-0003-1754-4138
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, National Medical Center, 
      Seoul, Korea.
FAU - Lee, Sangjun
AU  - Lee S
AUID- ORCID: 0000-0003-4080-0494
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Mo, Ji-Hun
AU  - Mo JH
AUID- ORCID: 0000-0003-1331-364X
AD  - Department of Otorhinolaryngology, Dankook University College of Medicine, 
      Cheonan, Korea.
FAU - Shin, Seung-Heon
AU  - Shin SH
AUID- ORCID: 0000-0002-9118-0590
AD  - Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu 
      Catholic University, Daegu, Korea. hsseung@cu.ac.kr.
FAU - Kim, Dae Woo
AU  - Kim DW
AUID- ORCID: 0000-0001-5166-3072
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul Metropolitan 
      Government-Seoul National University Boramae Medical Center, Seoul National 
      University College of Medicine, Seoul, Korea. kicubi73@gmail.com.
LA  - eng
GR  - 04-2021-0008/Seoul Metropolitan Government Seoul National University Boramae 
      Medical Center/Korea
GR  - NRF-2019R1A2C208717014/NRF/National Research Foundation of Korea/Korea
PT  - Journal Article
DEP - 20230126
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC10359642
OTO - NOTNLM
OT  - Asians
OT  - biomarker
OT  - cluster analysis
OT  - multicenter study
OT  - nasal polyps
OT  - sinusitis
OT  - surgery
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2023/04/20 00:41
MHDA- 2023/04/20 00:42
PMCR- 2023/07/01
CRDT- 2023/04/19 19:13
PHST- 2022/08/07 00:00 [received]
PHST- 2022/11/28 00:00 [revised]
PHST- 2022/12/13 00:00 [accepted]
PHST- 2023/04/20 00:42 [medline]
PHST- 2023/04/20 00:41 [pubmed]
PHST- 2023/04/19 19:13 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - 15.e21 [pii]
AID - 10.4168/aair.2023.15.4.437 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2023 Jul;15(4):437-450. doi: 
      10.4168/aair.2023.15.4.437. Epub 2023 Jan 26.