PMID- 37076246
OWN - NLM
STAT- MEDLINE
DCOM- 20230623
LR  - 20230623
IS  - 1543-2742 (Electronic)
IS  - 1526-484X (Linking)
VI  - 33
IP  - 4
DP  - 2023 Jul 1
TI  - Effects of Changes in Body Fat Mass as a Result of Regular Exercise on Hemoglobin 
      A1c in Patients With Type 2 Diabetes Mellitus: A Meta-Analysis.
PG  - 209-221
LID - 10.1123/ijsnem.2022-0217 [doi]
AB  - An increase in visceral fat is associated with an increase in insulin resistance, 
      so reducing body fat mass through exercise may help alleviate type 2 diabetes 
      mellitus (T2DM). The current meta-analysis evaluated the effect of changes in 
      body fat via an intervention of regular exercise on hemoglobin A1c (HbA1c) in 
      patients with T2DM. The inclusion criteria were randomized controlled trials 
      involving adults with T2DM, intervention involving exercise alone, an overall 
      duration of intervention >/=12 weeks, and reporting HbA1c and body fat mass. The 
      mean differences (MDs) were defined as the MD between the exercise group and the 
      control group, and the MDs in HbA1c (in percentage) and body fat mass (in 
      kilograms) were calculated. All MDs in HbA1c were pooled as overall effects. A 
      meta-regression analysis was performed to evaluate the relationship between the 
      MD in the body fat mass (in kilograms) and the MD in HbA1c. Twenty studies (1,134 
      subjects) were analyzed. The pooled MD in HbA1c (in percentage) decreased 
      significantly (-0.4; 95% confidence interval [-0.5, -0.3]) but contained 
      significant heterogeneity (Q = 52.7, p < .01; I2 = 41.6%). A meta-regression 
      analysis showed that a decrease in the MD in body fat mass was significantly 
      associated with a decrease in the MD in HbA1c (R2 = 80.0%) and heterogeneity 
      decreased (Q = 27.3, p = .61; I2 = 11.9%), and a reduction in body fat mass of 
      1 kg was estimated to decrease the HbA1c (%) by approximately 0.2. The current 
      study suggested that a decrease in HbA1c due to regular exercise depends on a 
      reduction in body fat mass in patients with T2DM.
FAU - Igarashi, Yutaka
AU  - Igarashi Y
AUID- ORCID: 0000-0003-0012-4225
AD  - Osaka Metropolitan University, Osaka,Japan.
FAU - Akazawa, Nobuhiko
AU  - Akazawa N
AD  - Faculty of Sport Sciences, Waseda University, Tokorozawa,Japan.
FAU - Maeda, Seiji
AU  - Maeda S
AD  - Faculty of Sport Sciences, Waseda University, Tokorozawa,Japan.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20230419
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Glycated Hemoglobin
MH  - Exercise
MH  - *Insulin Resistance
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - exercise therapy
OT  - meta-regression analysis
OT  - randomized controlled trial
OT  - systematic review
EDAT- 2023/04/20 00:42
MHDA- 2023/06/23 06:42
CRDT- 2023/04/19 21:02
PHST- 2022/10/25 00:00 [received]
PHST- 2023/01/31 00:00 [revised]
PHST- 2023/02/20 00:00 [accepted]
PHST- 2023/06/23 06:42 [medline]
PHST- 2023/04/20 00:42 [pubmed]
PHST- 2023/04/19 21:02 [entrez]
AID - 10.1123/ijsnem.2022-0217 [doi]
PST - epublish
SO  - Int J Sport Nutr Exerc Metab. 2023 Apr 19;33(4):209-221. doi: 
      10.1123/ijsnem.2022-0217. Print 2023 Jul 1.