PMID- 3707649
OWN - NLM
STAT- MEDLINE
DCOM- 19860528
LR  - 20131121
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 36
IP  - 2A
DP  - 1986 Feb
TI  - Comparison of the acute hemodynamic effects of ibopamine and dopamine in chronic 
      congestive heart failure.
PG  - 355-9
AB  - The acute hemodynamic effects of ibopamine (SB-7505), the 3,4-diisobutyryl ester 
      of N-methyldopamine which can be administered orally, were compared with those of 
      dopamine. Ten male patients aged 54 years on average, with chronic congestive 
      heart failure in NYHA (New York Heart Association) classes II-IV were studied. 
      Eight of them were suffering from idiopathic congestive cardiomyopathy and two 
      from ischemic cardiopathy. Baseline hemodynamic parameters were recorded within 
      24 h after withdrawal of previous treatment, the patients being kept on digitalis 
      only. The investigation was carried out for a period of 3 days running. On day 1 
      of treatment one group of 5 patients were given dopamine at increasing doses of 
      2, 4 and 6 micrograms/kg/min. Their hemodynamic parameters were assessed 15 min 
      after each dose and 15 and 60 min after withdrawal of the drug. Ibopamine was 
      then administered orally in single doses of 50 mg on day 2 and 100 mg on day 3. 
      The hemodynamic parameters were evaluated at 30, 60, 90, 120, 180, 360 and 480 
      min after administration. On day 1, another group of 5 patients were given 50 mg 
      ibopamine, on day 2, 100 mg ibopamine and on day 3, dopamine. Hemodynamic data in 
      this group of patients were evaluated at the same times mentioned above. The 
      hemodynamic effects of ibopamine 100 mg are very similar to those obtained with 4 
      micrograms/kg/min dopamine. Indeed, the effects of both drugs on the cardiac 
      index, right atrial pressure, peripheral and pulmonary vascular resistance do not 
      differ significantly from each other.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Sannia, L
AU  - Sannia L
FAU - Ibba, G V
AU  - Ibba GV
FAU - Castellaccio, M
AU  - Castellaccio M
FAU - Dore, L
AU  - Dore L
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Cardiotonic Agents)
RN  - 8ZCA2I2L11 (ibopamine)
RN  - R7339QLN1C (Deoxyepinephrine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Cardiac Output/drug effects
MH  - Cardiotonic Agents/*therapeutic use
MH  - Chronic Disease
MH  - Deoxyepinephrine/*analogs & derivatives/therapeutic use
MH  - Dopamine/*analogs & derivatives/*therapeutic use
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1986/02/01 00:00
MHDA- 1986/02/01 00:01
CRDT- 1986/02/01 00:00
PHST- 1986/02/01 00:00 [pubmed]
PHST- 1986/02/01 00:01 [medline]
PHST- 1986/02/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1986 Feb;36(2A):355-9.