PMID- 37076505
OWN - NLM
STAT- MEDLINE
DCOM- 20230421
LR  - 20230427
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Apr 19
TI  - Clinical implications of choroidal vascular brightness using ultra-widefield 
      indocyanine green angiography in polypoidal choroidal vasculopathy.
PG  - 6400
LID - 10.1038/s41598-023-31745-y [doi]
LID - 6400
AB  - Polypoidal choroidal vasculopathy (PCV) is characterized by choroidal vascular 
      abnormalities including polypoidal lesion and branching vascular networks. Not 
      only choroidal structural changes, but also choroidal hyperpermeability and 
      congestion are also thought to be involved in pathogenesis of PCV. We 
      investigated choroidal vascular brightness intensity (CVB) using ultra-widefield 
      indocyanine green angiography (UWF-ICGA) images and analyzed its association with 
      clinical features in patients with PCV. In this study, 33 eyes with PCV and 27 
      eyes of age-matched controls were included. CVB was measured by extracting the 
      enhanced pixels of choroidal vessels after the reference brightness across the 
      images was adjusted to be uniform. Associations between choroidal vascular 
      features and the clinical features of PCV were also determined. The mean CVB was 
      higher in PCV than control eyes, regardless of the segmented region (all 
      p < 0.001). CVB was also higher at the posterior pole than at the periphery, and 
      the inferior quadrants were brighter than the superior quadrants in both the PCV 
      and control group (all p < 0.05). In affected eyes, CVB was higher than in 
      unaffected fellow eyes at the posterior pole, whereas there was no difference at 
      the periphery. Posterior pole CVB correlated significantly with subfoveal 
      choroidal thickness (r = 0.502, p = 0.005), polyp number (r = 0.366 p = 0.030), 
      and the greatest linear dimension (r = 0.680, p = 0.040). Greatest linear 
      dimension was positively correlated with CVB at posterior pole (p = 0.040), 
      whereas SFCT or CVD in all regions didn't show the significant correlation. The 
      UWF ICGA results showed an increase in CVB at the inferior quadrants and 
      posterior pole, suggesting venous outflow congestion in PCV eyes. CVB might 
      provide more substantial information on the phenotype than other choroidal 
      vascular features.
CI  - (c) 2023. The Author(s).
FAU - Jeong, Areum
AU  - Jeong A
AD  - Department of Ophthalmology, Yeungnam University College of Medicine, #170 
      Hyunchungro, Nam-Gu, Daegu, 42415, South Korea.
AD  - Yeungnam Eye Center, Yeungnam University Hospital, Daegu, South Korea.
FAU - Yao, Xue
AU  - Yao X
AD  - Department of Ophthalmology, Yeungnam University College of Medicine, #170 
      Hyunchungro, Nam-Gu, Daegu, 42415, South Korea.
FAU - Lee, Kyungmin
AU  - Lee K
AD  - Department of Robotic Engineering, DGIST, #333, Techno Jungang-Daero, 
      Dalseong-Gun, Daegu, South Korea.
FAU - Park, Sang Hyun
AU  - Park SH
AD  - Department of Robotic Engineering, DGIST, #333, Techno Jungang-Daero, 
      Dalseong-Gun, Daegu, South Korea.
FAU - Sagong, Min
AU  - Sagong M
AD  - Department of Ophthalmology, Yeungnam University College of Medicine, #170 
      Hyunchungro, Nam-Gu, Daegu, 42415, South Korea. msagong@yu.ac.kr.
AD  - Yeungnam Eye Center, Yeungnam University Hospital, Daegu, South Korea. 
      msagong@yu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230419
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - IX6J1063HV (Indocyanine Green)
RN  - 0 (Coloring Agents)
SB  - IM
MH  - Humans
MH  - Indocyanine Green
MH  - Fluorescein Angiography
MH  - Polypoidal Choroidal Vasculopathy
MH  - Choroid/blood supply
MH  - Tomography, Optical Coherence
MH  - *Polyps/diagnostic imaging/pathology
MH  - Retrospective Studies
MH  - *Choroidal Neovascularization/diagnostic imaging/pathology
MH  - Coloring Agents/pharmacology
PMC - PMC10115771
COIS- The authors declare no competing interests.
EDAT- 2023/04/20 00:41
MHDA- 2023/04/21 06:42
PMCR- 2023/04/19
CRDT- 2023/04/19 23:16
PHST- 2022/12/27 00:00 [received]
PHST- 2023/03/16 00:00 [accepted]
PHST- 2023/04/21 06:42 [medline]
PHST- 2023/04/20 00:41 [pubmed]
PHST- 2023/04/19 23:16 [entrez]
PHST- 2023/04/19 00:00 [pmc-release]
AID - 10.1038/s41598-023-31745-y [pii]
AID - 31745 [pii]
AID - 10.1038/s41598-023-31745-y [doi]
PST - epublish
SO  - Sci Rep. 2023 Apr 19;13(1):6400. doi: 10.1038/s41598-023-31745-y.