PMID- 37077062
OWN - NLM
STAT- MEDLINE
DCOM- 20230421
LR  - 20230421
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 66
IP  - 2
DP  - 2023 Apr-Jun
TI  - Relationship of E-cadherin, Beta-catenin, N-cadherin, ZEB1 and alphaSMA as Epithelial 
      Mesenchymal Transition markers with prognostic factors in early and advanced 
      stage laryngeal squamous cell carcinomas.
PG  - 237-245
LID - 10.4103/ijpm.ijpm_530_21 [doi]
AB  - AIMS: To investigate the relationship between E-cadherin, beta-catenin, 
      N-cadherin, ZEB1, and alphaSMA as epithelial-mesenchymal transformation markers with 
      tumor stage, lymph node metastasis (LNM), and overall survival (OS) in laryngeal 
      squamous cell carcinomas (LSCC). MATERIALS AND METHODS: A total of 100 cases 
      diagnosed with LSCC were included in the study. Data about the lymphovascular 
      invasion (LVI), perineural invasion (PNI), necrosis, and LNM were recorded by 
      evaluating hematoxylin-eosin-stained slides. Markers of E-cadherin, beta-catenin, 
      N-cadherin, ZEB1, and alphaSMA were applied to the sections prepared from paraffin 
      blocks of tumor samples. RESULTS: Ninety-five male and five female patients were 
      included in the study, and 38 of them exited. A significant relationship was 
      observed between OS with advanced tumor stage, presence of LNM and PNI. A 
      significant relationship was found between increased tumor Zeb1 expression and 
      advanced tumor stage. In univariate and multivariate analyses, a significant 
      negative relationship with OS, and increased Zeb1 expression in tumor and tumor 
      stroma was seen. Any relationship was not observed between E-cadherin, 
      beta-catenin, N-cadherin, and alphaSMA and OS. CONCLUSION: Among the EMT markers, we 
      evaluated in our study, it was seen that Zeb1, which is an EMT transcription 
      factor, is associated with tumor stage, LNM, and OS. Remarkably, Zeb1 expression 
      observed in tumor stroma was also significant for OS. Any similar data reported 
      for LSCCs have not been encountered in the literature, and it was thought that it 
      would be appropriate to support our findings with further studies to be performed 
      on this subject.
FAU - Kucuk, Ulku
AU  - Kucuk U
AD  - Department of Pathology, Izmir Faculty of Medicine, University of Health 
      Sciences, Turkey.
FAU - Ekmekci, Sumeyye
AU  - Ekmekci S
AD  - Department of Pathology, Izmir Faculty of Medicine, University of Health 
      Sciences, Turkey.
FAU - Talu, Canan K
AU  - Talu CK
AD  - Department of Pathology, Izmir Faculty of Medicine, University of Health 
      Sciences, Turkey.
FAU - Pekcevik, Yeliz
AU  - Pekcevik Y
AD  - Department of Radiology, Izmir Faculty of Medicine, University of Health 
      Sciences, Turkey.
FAU - Cukurova, Ibrahim
AU  - Cukurova I
AD  - Department of Head and Neck Surgery, Izmir Faculty of Medicine, University of 
      Health Sciences, Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
RN  - 0 (beta Catenin)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cadherins)
RN  - 0 (ZEB1 protein, human)
RN  - 0 (Zinc Finger E-box-Binding Homeobox 1)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *beta Catenin/metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Epithelial-Mesenchymal Transition
MH  - Prognosis
MH  - Biomarkers, Tumor/analysis
MH  - Cadherins/metabolism
MH  - *Head and Neck Neoplasms
MH  - Zinc Finger E-box-Binding Homeobox 1/genetics
OTO - NOTNLM
OT  - E-cadherin
OT  - N-cadherin
OT  - ZEB1
OT  - beta-catenin
OT  - laryngeal carcinoma
OT  - alphaSMA
COIS- None
EDAT- 2023/04/20 06:41
MHDA- 2023/04/21 06:41
CRDT- 2023/04/20 01:40
PHST- 2023/04/21 06:41 [medline]
PHST- 2023/04/20 06:41 [pubmed]
PHST- 2023/04/20 01:40 [entrez]
AID - IndianJPatholMicrobiol_2023_66_2_237_345153 [pii]
AID - 10.4103/ijpm.ijpm_530_21 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2023 Apr-Jun;66(2):237-245. doi: 
      10.4103/ijpm.ijpm_530_21.