PMID- 37078543
OWN - NLM
STAT- Publisher
LR  - 20230426
IS  - 2046-5556 (Electronic)
IS  - 0264-8725 (Linking)
DP  - 2023 Apr 20
TI  - Effect of early preventive use of caffeine citrate on prevention together with 
      treatment of BPD within premature infants and its influence on inflammatory 
      factors.
PG  - 1-15
LID - 10.1080/02648725.2023.2202517 [doi]
AB  - OBJECTIVE: To explore caffeine citrate prophylactic and therapeutic influences 
      upon broncho-pulmonary dysplasia (BPD) within premature infants and its influence 
      on inflammatory factors. METHODS: A total of 128 premature infants from January 
      2021 to June 2022 were investigated, segregated within control group and 
      observation group through randomized number table protocol, having 64 cases per 
      group. RESULTS: Effective rate of observation group was elevated in comparison to 
      control group (95.31% versus 84.38%, P < 0.05). The number of apnea of 
      prematurity (AOP) in observation group was reduced in comparison to control 
      group, while duration of auxiliary ventilation together with hospitalization days 
      were reduced in comparison to control group (P < 0.05). Post-therapy, matrix 
      metalloproteinase-9 (MMP-9), tumor necrosis factor (TNF-alpha) and Toll-like 
      receptor-4 (TLR-4) were downregulated within observation group, while scorings 
      for psychomotor development index (PDI) and mental development index (MDI) in 
      observation group were elevated in comparison to control group (P < 0.05). 
      Weight-gain rate and growth rate of body length within observation group was 
      elevated in comparison to control group (P < 0.05). Post-therapy, work of 
      breathing (WOB) and airway resistance (Raw) within observation group were lower 
      compared to control group, while respiratory system compliance (Crs) was elevated 
      in comparison to control group (P < 0.05). Occurrences of broncho-pulmonary 
      dysplasia (BPD) within observation group was reduced in comparison to control 
      group (P < 0.05). CONCLUSION: Early prophylactic use of caffeine citrate can 
      effectively reduce the incidence of BPD in premature infants.
FAU - Jiang, Qian
AU  - Jiang Q
AD  - Department of Pediatrics, Chengyang People's Hospital, Qingdao, Shandong, China.
FAU - Wu, Xiaoping
AU  - Wu X
AD  - Department of Pediatrics, Chengyang People's Hospital, Qingdao, Shandong, China.
LA  - eng
PT  - Journal Article
DEP - 20230420
PL  - England
TA  - Biotechnol Genet Eng Rev
JT  - Biotechnology & genetic engineering reviews
JID - 8510274
SB  - IM
OTO - NOTNLM
OT  - Caffeine citrate
OT  - bronchopulmonary dysplasia
OT  - inflammatory factor
OT  - premature infants
OT  - prevention and treatment
EDAT- 2023/04/20 13:41
MHDA- 2023/04/20 13:41
CRDT- 2023/04/20 07:42
PHST- 2023/04/20 13:41 [pubmed]
PHST- 2023/04/20 13:41 [medline]
PHST- 2023/04/20 07:42 [entrez]
AID - 10.1080/02648725.2023.2202517 [doi]
PST - aheadofprint
SO  - Biotechnol Genet Eng Rev. 2023 Apr 20:1-15. doi: 10.1080/02648725.2023.2202517.