PMID- 37079309
OWN - NLM
STAT- MEDLINE
DCOM- 20230602
LR  - 20230604
IS  - 1479-6821 (Electronic)
IS  - 1351-0088 (Linking)
VI  - 30
IP  - 7
DP  - 2023 Jul 1
TI  - Genome-wide association studies in advanced prostate cancer: KYUCOG-1401-A study.
LID - e230044 [pii]
LID - 10.1530/ERC-23-0044 [doi]
AB  - Androgen-deprivation therapy (ADT) has been widely used for the treatment of 
      advanced prostate cancer. However, prognosis and adverse events (AEs) vary among 
      patients. This study aimed to identify genetic markers able to predict the 
      outcome of ADT. Japanese patients treated with primary ADT for advanced prostate 
      cancer in the KYUCOG-1401 trial were enrolled as a development set. A distinct 
      population of advanced prostate cancer cases treated with ADT was included as a 
      validation set. Single-nucleotide polymorphisms (SNPs) associated with 
      radiographic progression-free survival (rPFS) at 1 year and AEs including de novo 
      diabetes mellitus (DM), arthralgia, and de novo dyslipidemia were identified in 
      the development set by a genome-wide association study (GWAS). The SNPs 
      associated with rPFS in the development study were then genotyped in the 
      validation set. GWAS followed by validation identified SNPs (rs76237622 in PRR27 
      and rs117573572 in MTAP) that were associated with overall survival (OS) in ADT. 
      A genetic prognostic model using these SNPs showed excellent predictive efficacy 
      for PFS and OS in ADT. In addition, GWAS showed that several SNPs were associated 
      with de novo DM, arthralgia, and de novo dyslipidemia in ADT. This study 
      identified novel multiple SNPs that correlated with outcomes in ADT. Future 
      studies on correlations affecting the therapeutic efficacy of ADT-based 
      combination therapies would make a valuable contribution to the development of 
      personalized medicine.
FAU - Shiota, Masaki
AU  - Shiota M
AUID- ORCID: 0000-0002-3306-4858
AD  - Department of Urology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
FAU - Tatarano, Shuichi
AU  - Tatarano S
AUID- ORCID: 0000-0003-4224-5084
AD  - Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima 
      University, Kagoshima, Japan.
FAU - Kamoto, Toshiyuki
AU  - Kamoto T
AD  - Department of Urology, Faculty of Medicine, Miyazaki University, Miyazaki, Japan.
FAU - Matsuyama, Hideyasu
AU  - Matsuyama H
AD  - Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, 
      Japan.
FAU - Sakai, Hideki
AU  - Sakai H
AD  - Department of Urology, Graduate School of Biomedical Sciences, Nagasaki 
      University, Nagasaki, Japan.
FAU - Igawa, Tsukasa
AU  - Igawa T
AD  - Department of Urology, School of Medicine, Kurume University, Kurume, Japan.
FAU - Kamba, Tomomi
AU  - Kamba T
AD  - Department of Urology, Kumamoto University, Kumamoto, Japan.
FAU - Fujimoto, Naohiro
AU  - Fujimoto N
AD  - Department of Urology, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Sekine, Yuya
AU  - Sekine Y
AD  - Laboratory for Genotyping Development, RIKEN Center for Integrative Medical 
      Sciences, Yokohama, Japan.
AD  - Department of Urology, Graduate School of Medicine, Akita University, Akita, 
      Japan.
FAU - Kimura, Hiroko
AU  - Kimura H
AD  - Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, 
      Japan.
FAU - Narita, Shintaro
AU  - Narita S
AD  - Department of Urology, Graduate School of Medicine, Akita University, Akita, 
      Japan.
FAU - Terada, Naoki
AU  - Terada N
AD  - Department of Urology, Faculty of Medicine, Miyazaki University, Miyazaki, Japan.
FAU - Momozawa, Yukihide
AU  - Momozawa Y
AD  - Laboratory for Genotyping Development, RIKEN Center for Integrative Medical 
      Sciences, Yokohama, Japan.
FAU - Akamatsu, Shusuke
AU  - Akamatsu S
AD  - Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, 
      Japan.
FAU - Habuchi, Tomonori
AU  - Habuchi T
AD  - Department of Urology, Graduate School of Medicine, Akita University, Akita, 
      Japan.
FAU - Yokomizo, Akira
AU  - Yokomizo A
AD  - Department of Urology, Harasanshin Hospital, Fukuoka, Japan.
FAU - Naito, Seiji
AU  - Naito S
AD  - Department of Urology, Harasanshin Hospital, Fukuoka, Japan.
FAU - Eto, Masatoshi
AU  - Eto M
AD  - Department of Urology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230601
PL  - England
TA  - Endocr Relat Cancer
JT  - Endocrine-related cancer
JID - 9436481
RN  - 0 (Androgen Antagonists)
SB  - IM
MH  - Male
MH  - Humans
MH  - *Prostatic Neoplasms/drug therapy/genetics
MH  - Genome-Wide Association Study
MH  - Androgen Antagonists/therapeutic use
MH  - Prognosis
MH  - *Diabetes Mellitus/drug therapy
OTO - NOTNLM
OT  - advanced prostate cancer
OT  - androgen-deprivation therapy
OT  - genome-wide association study
OT  - prognosis
OT  - validation
EDAT- 2023/04/20 13:41
MHDA- 2023/06/02 06:43
CRDT- 2023/04/20 11:33
PHST- 2023/04/11 00:00 [received]
PHST- 2023/04/20 00:00 [accepted]
PHST- 2023/06/02 06:43 [medline]
PHST- 2023/04/20 13:41 [pubmed]
PHST- 2023/04/20 11:33 [entrez]
AID - e230044 [pii]
AID - 10.1530/ERC-23-0044 [doi]
PST - epublish
SO  - Endocr Relat Cancer. 2023 Jun 1;30(7):e230044. doi: 10.1530/ERC-23-0044. Print 
      2023 Jul 1.