PMID- 37080084
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 285
DP  - 2023 Jun
TI  - No difference in morbidity between perimenopausal women with PCOS with and 
      without previous wedge resection.
PG  - 74-78
LID - S0301-2115(23)00156-2 [pii]
LID - 10.1016/j.ejogrb.2023.04.008 [doi]
AB  - OBJECTIVE: Polycystic ovary syndrome (PCOS), affecting more than every 10th woman 
      of reproductive age, is associated with increased risk factors for cardiovascular 
      disease (CVD). Most knowledge regarding longtime consequences concerning 
      morbidity is based on women where ovarian wedge resection (WR) was used as a 
      surgical treatment, a method not used today. The aim of this study was to compare 
      women with PCOS who had and had not undergone WR, regarding risk factors for CVD. 
      The hypothesis was that women who had undergone WR had a more severe PCOS 
      phenotype, and that this cohort thus had more associated CVD risk factors 
      compared with women diagnosed through non-invasive methods. STUDY DESIGN: A 
      cross-sectional study was performed. A PCOS cohort who underwent WR in the 
      1950-60 s (n = 27) were compared with a PCOS cohort diagnosed by NIH-criterions 
      in the 1990s without WR (n = 32). Both cohorts were examined at perimenopausal 
      age. RESULTS: No differences were seen in prevalence of hypertension, obesity or 
      type 2 diabetes mellitus (T2DM) between the women with PCOS with or without WR, 
      respectively. The results were persistent irrespective of the lower mean BMI in 
      the WR group, 26.4 vs. 30.7 kg/m(2), p = 0.01. In the stratified group of 
      overweight and obese, there was no difference in T2DM 27% vs 25% or hypertension 
      27% vs 25%, in WR and non-WR women with PCOS, respectively. The cohort diagnosed 
      through WR had higher free androgen index (6.3 vs. 2.1, p < 0.01) and total 
      testosterone (2.20 vs. 0.99 nmol/L, p < 0.01). CONCLUSION: No differences in CVD 
      risk factors were found in perimenopausal women with PCOS with or without a 
      previous WR, and irrespective of body weight. The results indicate that CVD 
      morbidity and mortality from studies in women with PCOS who have undergone WR are 
      generalizable to women with PCOS who have not undergone WR.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Forslund, Maria
AU  - Forslund M
AD  - Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 
      Sweden; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, 
      Gothenburg, Sweden. Electronic address: maria.forslund@gu.se.
FAU - Landin-Wilhelmsen, Kerstin
AU  - Landin-Wilhelmsen K
AD  - Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; 
      Section for Endocrinology, Sahlgrenska University Hospital, SE-41345 Gothenburg, 
      Sweden.
FAU - Brannstrom, Mats
AU  - Brannstrom M
AD  - Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 
      Sweden.
FAU - Dahlgren, Eva
AU  - Dahlgren E
AD  - Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 
      Sweden.
LA  - eng
PT  - Journal Article
DEP - 20230417
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polycystic Ovary Syndrome
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cross-Sectional Studies
MH  - Perimenopause
MH  - Obesity/epidemiology
MH  - Morbidity
MH  - *Hypertension/complications
MH  - *Cardiovascular Diseases/epidemiology/etiology
MH  - Body Mass Index
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Diabetes
OT  - Hypertension
OT  - Menopausal
OT  - PCOS
OT  - Wedge resection
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/04/21 00:42
MHDA- 2023/05/22 06:42
CRDT- 2023/04/20 18:06
PHST- 2023/02/19 00:00 [received]
PHST- 2023/03/29 00:00 [revised]
PHST- 2023/04/12 00:00 [accepted]
PHST- 2023/05/22 06:42 [medline]
PHST- 2023/04/21 00:42 [pubmed]
PHST- 2023/04/20 18:06 [entrez]
AID - S0301-2115(23)00156-2 [pii]
AID - 10.1016/j.ejogrb.2023.04.008 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2023 Jun;285:74-78. doi: 
      10.1016/j.ejogrb.2023.04.008. Epub 2023 Apr 17.