PMID- 37080369
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230604
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 145
DP  - 2023 Aug
TI  - Evolution of LPS recognition and signaling: The bony fish perspective.
PG  - 104710
LID - S0145-305X(23)00080-0 [pii]
LID - 10.1016/j.dci.2023.104710 [doi]
AB  - Fish are the most diverse and successful group of vertebrate animals, with about 
      30,000 species. The study of fish immunity is of great importance for 
      understanding the evolution of vertebrate immunity, as they are the first animals 
      to show both innate and adaptive immune responses. Although fish immunity is 
      similar to that of mammals, there are obvious differences, such as their 
      dependence of ambient temperature, their poor antibody response, and lack of 
      antibody switching and lymph nodes. In addition, several important differences 
      have also been found between the innate immune responses of fish and mammals. 
      Among these, we will discuss in this review the high resistance of fish to the 
      toxic effects of lipopolysaccharide (LPS) which can be explained by the absence 
      of a Toll-like receptor 4 (Tlr4) ortholog in most fish species or by the 
      inability of the Tlr4/Md2 (Myeloid differentiation 2) complex to recognize LPS, 
      together with the presence of a negative regulator of the LPS signaling complex 
      formed by the TLR-like molecule Rp105 (Radioprotective 105) and Md1. Taken 
      together, these data support the idea that, although TLR4 and RP105 arose from a 
      common ancestor to fish and tetrapods, the TLR4/MD2 receptor complex for LPS 
      recognition arose after their divergence about 450 million years ago.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Martinez-Lopez, Alicia
AU  - Martinez-Lopez A
AD  - Instituto Murciano de Investigacion Biosanitaria (IMIB)-Arrixaca, 30120, Murcia, 
      Spain; Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), 
      Instituto de Salud Carlos III, 28029, Madrid, Spain. Electronic address: 
      alicia.martinez34@um.es.
FAU - Tyrkalska, Sylwia D
AU  - Tyrkalska SD
AD  - Departamento de Biologia Celular e Histologia, Facultad de Biologia, Universidad 
      de Murcia, 30100, Murcia, Spain; Instituto Murciano de Investigacion Biosanitaria 
      (IMIB)-Arrixaca, 30120, Murcia, Spain; Centro de Investigacion Biomedica en Red 
      de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029, Madrid, 
      Spain.
FAU - Alcaraz-Perez, Francisca
AU  - Alcaraz-Perez F
AD  - Instituto Murciano de Investigacion Biosanitaria (IMIB)-Arrixaca, 30120, Murcia, 
      Spain; Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), 
      Instituto de Salud Carlos III, 28029, Madrid, Spain; Hospital Clinico 
      Universitario Virgen de la Arrixaca, 30120, Murcia, Spain.
FAU - Cabas, Isabel
AU  - Cabas I
AD  - Departamento de Biologia Celular e Histologia, Facultad de Biologia, Universidad 
      de Murcia, 30100, Murcia, Spain; Instituto Murciano de Investigacion Biosanitaria 
      (IMIB)-Arrixaca, 30120, Murcia, Spain; Centro de Investigacion Biomedica en Red 
      de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029, Madrid, 
      Spain.
FAU - Candel, Sergio
AU  - Candel S
AD  - Departamento de Biologia Celular e Histologia, Facultad de Biologia, Universidad 
      de Murcia, 30100, Murcia, Spain; Instituto Murciano de Investigacion Biosanitaria 
      (IMIB)-Arrixaca, 30120, Murcia, Spain; Centro de Investigacion Biomedica en Red 
      de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029, Madrid, 
      Spain.
FAU - Martinez Morcillo, Francisco J
AU  - Martinez Morcillo FJ
AD  - Departamento de Biologia Celular e Histologia, Facultad de Biologia, Universidad 
      de Murcia, 30100, Murcia, Spain; Instituto Murciano de Investigacion Biosanitaria 
      (IMIB)-Arrixaca, 30120, Murcia, Spain; Centro de Investigacion Biomedica en Red 
      de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029, Madrid, 
      Spain.
FAU - Sepulcre, Maria P
AU  - Sepulcre MP
AD  - Departamento de Biologia Celular e Histologia, Facultad de Biologia, Universidad 
      de Murcia, 30100, Murcia, Spain; Instituto Murciano de Investigacion Biosanitaria 
      (IMIB)-Arrixaca, 30120, Murcia, Spain; Centro de Investigacion Biomedica en Red 
      de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029, Madrid, 
      Spain.
FAU - Garcia-Moreno, Diana
AU  - Garcia-Moreno D
AD  - Departamento de Biologia Celular e Histologia, Facultad de Biologia, Universidad 
      de Murcia, 30100, Murcia, Spain; Centro de Investigacion Biomedica en Red de 
      Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029, Madrid, 
      Spain.
FAU - Cayuela, Maria L
AU  - Cayuela ML
AD  - Instituto Murciano de Investigacion Biosanitaria (IMIB)-Arrixaca, 30120, Murcia, 
      Spain; Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), 
      Instituto de Salud Carlos III, 28029, Madrid, Spain; Hospital Clinico 
      Universitario Virgen de la Arrixaca, 30120, Murcia, Spain.
FAU - Mulero, Victoriano
AU  - Mulero V
AD  - Departamento de Biologia Celular e Histologia, Facultad de Biologia, Universidad 
      de Murcia, 30100, Murcia, Spain; Instituto Murciano de Investigacion Biosanitaria 
      (IMIB)-Arrixaca, 30120, Murcia, Spain; Centro de Investigacion Biomedica en Red 
      de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029, Madrid, 
      Spain. Electronic address: vmulero@um.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230418
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Lymphocyte Antigen 96)
SB  - IM
MH  - Animals
MH  - *Lipopolysaccharides
MH  - *Toll-Like Receptor 4/metabolism
MH  - Signal Transduction
MH  - Fishes
MH  - Immunity, Innate
MH  - Lymphocyte Antigen 96
MH  - Mammals
OTO - NOTNLM
OT  - Inflammation
OT  - Innate immunity
OT  - LPS
OT  - MD1
OT  - MD2
OT  - RP105
OT  - TLR4
OT  - Zebrafish
COIS- Declaration of competing interest No potential conflict of interest was reported 
      by the authors.
EDAT- 2023/04/21 00:42
MHDA- 2023/05/29 06:42
CRDT- 2023/04/20 19:25
PHST- 2023/03/02 00:00 [received]
PHST- 2023/04/03 00:00 [revised]
PHST- 2023/04/10 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/04/21 00:42 [pubmed]
PHST- 2023/04/20 19:25 [entrez]
AID - S0145-305X(23)00080-0 [pii]
AID - 10.1016/j.dci.2023.104710 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2023 Aug;145:104710. doi: 10.1016/j.dci.2023.104710. Epub 2023 
      Apr 18.