PMID- 37080931
OWN - NLM
STAT- MEDLINE
DCOM- 20230424
LR  - 20230424
IS  - 1608-3040 (Electronic)
IS  - 0006-2979 (Linking)
VI  - 88
IP  - 4
DP  - 2023 Apr
TI  - Epigenetic Mechanisms Involved in the Effects of Maternal Hyperhomocysteinemia on 
      the Functional State of Placenta and Nervous System Plasticity in the Offspring.
PG  - 435-456
LID - 10.1134/S0006297923040016 [doi]
AB  - According to modern view, susceptibility to diseases, specifically to cognitive 
      and neuropsychiatric disorders, can form during embryonic development. Adverse 
      factors affecting mother during the pregnancy increase the risk of developing 
      pathologies. Despite the association between elevated maternal blood homocysteine 
      (Hcy) and fetal brain impairments, as well as cognitive deficits in the 
      offspring, the role of brain plasticity in the development of these pathologies 
      remains poorly studied. Here, we review the data on the negative impact of 
      hyperhomocysteinemia (HHcy) on the neural plasticity, in particular, its possible 
      influence on the offspring brain plasticity through epigenetic mechanisms, such 
      as changes in intracellular methylation potential, activity of DNA 
      methyltransferases, DNA methylation, histone modifications, and microRNA 
      expression in brain cells. Since placenta plays a key role in the transport of 
      nutrients and transmission of signals from mother to fetus, its dysfunction due 
      to aberrant epigenetic regulation can affect the development of fetal CNS. The 
      review also presents the data on the impact of maternal HHcy on the epigenetic 
      regulation in the placenta. The data presented in the review are not only 
      interesting from purely scientific point of view, but can help in understanding 
      the role of HHcy and epigenetic mechanisms in the pathogenesis of diseases, such 
      as pregnancy pathologies resulting in the delayed development of fetal brain, 
      cognitive impairments in the offspring during childhood, and neuropsychiatric and 
      neurodegenerative disorders later in life, as well as in the search for 
      approaches for their prevention using neuroprotectors.
FAU - Arutjunyan, Alexander V
AU  - Arutjunyan AV
AD  - Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, St. 
      Petersburg, 199034, Russia. alexarutiunjan@gmail.com.
AD  - St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 
      197110, Russia.
FAU - Milyutina, Yulia P
AU  - Milyutina YP
AD  - Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, St. 
      Petersburg, 199034, Russia.
AD  - St. Petersburg State Pediatric Medical University, St. Petersburg, 194100, 
      Russia.
FAU - Shcherbitskaia, Anastasia D
AU  - Shcherbitskaia AD
AD  - Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, St. 
      Petersburg, 199034, Russia.
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy 
      of Sciences, Saint Petersburg, 194223, Russia.
FAU - Kerkeshko, Gleb O
AU  - Kerkeshko GO
AD  - Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, St. 
      Petersburg, 199034, Russia.
AD  - St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 
      197110, Russia.
FAU - Zalozniaia, Irina V
AU  - Zalozniaia IV
AD  - Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, St. 
      Petersburg, 199034, Russia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biochemistry (Mosc)
JT  - Biochemistry. Biokhimiia
JID - 0376536
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Epigenesis, Genetic
MH  - *Hyperhomocysteinemia/metabolism
MH  - Placenta/metabolism
MH  - DNA Methylation
MH  - Nervous System/metabolism
OTO - NOTNLM
OT  - brain
OT  - epigenetic regulation
OT  - fetus
OT  - maternal (prenatal) hyperhomocysteinemia
OT  - neuronal plasticity
OT  - newborn
OT  - placenta
EDAT- 2023/04/21 00:41
MHDA- 2023/04/24 06:41
CRDT- 2023/04/20 23:02
PHST- 2023/04/24 06:41 [medline]
PHST- 2023/04/21 00:41 [pubmed]
PHST- 2023/04/20 23:02 [entrez]
AID - BCM88040531 [pii]
AID - 10.1134/S0006297923040016 [doi]
PST - ppublish
SO  - Biochemistry (Mosc). 2023 Apr;88(4):435-456. doi: 10.1134/S0006297923040016.