PMID- 37081228
OWN - NLM
STAT- MEDLINE
DCOM- 20230728
LR  - 20230728
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 46
IP  - 9
DP  - 2023 Sep
TI  - Maternal androgen excess increases the risk of pre-diabetes mellitus in male 
      offspring in later life: a long-term population-based follow-up study.
PG  - 1775-1785
LID - 10.1007/s40618-022-01972-7 [doi]
AB  - PURPOSE: Prenatal androgen exposure could be a source of early programming, 
      leading to the development of cardiometabolic diseases in later life. In this 
      study, we aimed to examine cardiometabolic disturbances in males exposed to 
      maternal androgen excess during their prenatal life. METHODS: In this prospective 
      population-based study, 409 male offspring with maternal hyperandrogenism (MHA), 
      and 954 male offspring without MHA, as controls, were included. Both groups of 
      male offspring were followed from the baseline to the date of the incidence of 
      events, censoring, or end of the study period, whichever came first. Age-scaled 
      unadjusted and adjusted Cox regression models were applied to assess the hazard 
      ratios (HR) and 95% confidence intervals (CIs) for the association between MHA 
      with pre-diabetes mellitus (Pre-DM), type 2 diabetes mellitus (T2DM), 
      pre-hypertension (Pre-HTN), hypertension (HTN), dyslipidemia, overweight, and 
      obesity in the offspring of both groups. Statistical analysis was performed using 
      the STATA software package; the significance level was set at P < 0.05. RESULTS: 
      A higher risk of Pre-DM (adjusted HR: 1.46 (1.20, 1.78)) was observed in male 
      offspring with MHA after adjustment for potential confounders, including body 
      mass index, education, and physical activity. However, no significant differences 
      were observed in the risk of T2DM, Pre-HTN, HTN, dyslipidemia, overweight, and 
      obesity in males with MHA compared to controls in both the unadjusted and 
      adjusted models. CONCLUSION: Maternal androgen excess increases the risk of 
      Pre-DM in male offspring in later life. More longitudinal studies with long 
      enough follow-up are needed to clarify the effects of MHA on the cardiometabolic 
      risk factors of male offspring in later life.
CI  - (c) 2023. The Author(s), under exclusive licence to Italian Society of 
      Endocrinology (SIE).
FAU - Farhadi-Azar, M
AU  - Farhadi-Azar M
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Arabi, Yaman Street, 
      VelenjakTehran, 1985717413, Iran.
FAU - Noroozzadeh, M
AU  - Noroozzadeh M
AUID- ORCID: 0000-0003-3769-5160
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Arabi, Yaman Street, 
      VelenjakTehran, 1985717413, Iran. noroozzadeh@endocrine.ac.ir.
FAU - Ghahremani, M
AU  - Ghahremani M
AD  - Department of Obstetrics and Gynecology, Education Program in Reproduction and 
      Development, Monash University, Melbourne, VIC, Australia.
FAU - Rahmati, M
AU  - Rahmati M
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Arabi, Yaman Street, 
      VelenjakTehran, 1985717413, Iran.
FAU - Saei Ghare Naz, M
AU  - Saei Ghare Naz M
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Arabi, Yaman Street, 
      VelenjakTehran, 1985717413, Iran.
FAU - Azizi, F
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Ramezani Tehrani, F
AU  - Ramezani Tehrani F
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Arabi, Yaman Street, 
      VelenjakTehran, 1985717413, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230420
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Androgens)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Male
MH  - Follow-Up Studies
MH  - *Diabetes, Gestational/epidemiology
MH  - Androgens
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Overweight/epidemiology
MH  - Prospective Studies
MH  - Obesity/epidemiology
MH  - *Hypertension/epidemiology/etiology
MH  - Body Mass Index
MH  - Risk Factors
OTO - NOTNLM
OT  - Maternal androgen excess
OT  - Offspring
OT  - Pre-diabetes mellitus
EDAT- 2023/04/21 00:42
MHDA- 2023/07/28 06:42
CRDT- 2023/04/20 23:30
PHST- 2022/08/24 00:00 [received]
PHST- 2022/11/20 00:00 [accepted]
PHST- 2023/07/28 06:42 [medline]
PHST- 2023/04/21 00:42 [pubmed]
PHST- 2023/04/20 23:30 [entrez]
AID - 10.1007/s40618-022-01972-7 [pii]
AID - 10.1007/s40618-022-01972-7 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2023 Sep;46(9):1775-1785. doi: 10.1007/s40618-022-01972-7. 
      Epub 2023 Apr 20.