PMID- 37081307
OWN - NLM
STAT- MEDLINE
DCOM- 20230526
LR  - 20230526
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 50
IP  - 6
DP  - 2023 Jun
TI  - NFR2/ABC transporter axis in drug resistance of breast cancer cells.
PG  - 5407-5414
LID - 10.1007/s11033-023-08384-7 [doi]
AB  - Breast cancer is one of the most serious malignancies among women, accounting for 
      about 12% of all cancers. The inherent complexity and heterogeneity of breast 
      cancer results in failure to respond to treatment in the advanced stages of the 
      disease. Breast cancer is caused by several genetic and environmental factors. 
      One of the significant factors involved in the development of breast cancer is 
      oxidative stress, which is generally regulated by nuclear factor erythroid 
      2-related factor 2 (NRF2). The level of NRF2 expression is low in healthy cells, 
      which maintains the balance of the antioxidant system; however, its expression is 
      higher in cancer cells, which have correlation characteristics such as 
      angiogenesis, stem cell formation, drug resistance, and metastasis. Drug 
      resistance increases with the upregulation of NRF2 expression, which contributes 
      to cell protection. NRF2 controls this mechanism by increasing the expression of 
      ATP-binding cassettes (ABCs). Considering the growing number of studies in this 
      field, we aimed to investigate the relationship between NRF2 and ABCs, as well as 
      their role in the development of drug resistance in breast cancer.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Sargazi, Zinat
AU  - Sargazi Z
AD  - Department of Anatomical Sciences, School of Medicine, Zahedan University of 
      Medical Sciences, Zahedan, Iran.
FAU - Yazdani, Yalda
AU  - Yazdani Y
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Tahavvori, Amir
AU  - Tahavvori A
AD  - Department of internal medicine, Faculty of Medicine, Urmia University of Medical 
      Sciences, Urmia, Iran.
FAU - Youshanlouei, Hamed Rahmani
AU  - Youshanlouei HR
AD  - Department of internal medicine, Faculty of Medicine, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
FAU - Alivirdiloo, Vahid
AU  - Alivirdiloo V
AD  - Medical Doctor Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, 
      Iran.
FAU - Beilankouhi, Elmira Aboutalebi Vand
AU  - Beilankouhi EAV
AD  - Department of Animal Biology, Faculty of Natural Science, University of Tabriz, 
      Tabriz, Iran.
FAU - Valilo, Mohammad
AU  - Valilo M
AUID- ORCID: 0000-0002-7675-3995
AD  - Department of Biochemistry, Faculty of Medicine, Urmia University of Medical 
      Sciences, Urmia, Iran. valilo.biomed@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230420
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (NF-E2-Related Factor 2)
SB  - IM
MH  - Humans
MH  - Female
MH  - *ATP-Binding Cassette Transporters/metabolism
MH  - *Breast Neoplasms/drug therapy/genetics/metabolism
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - Up-Regulation
MH  - Drug Resistance
OTO - NOTNLM
OT  - ATP-binding cassette (ABC)
OT  - Breast cancer
OT  - Drug resistance
OT  - Nuclear factor erythroid 2-related factor 2 (NRF2)
EDAT- 2023/04/21 00:42
MHDA- 2023/05/26 06:42
CRDT- 2023/04/20 23:32
PHST- 2022/12/15 00:00 [received]
PHST- 2023/03/07 00:00 [accepted]
PHST- 2023/05/26 06:42 [medline]
PHST- 2023/04/21 00:42 [pubmed]
PHST- 2023/04/20 23:32 [entrez]
AID - 10.1007/s11033-023-08384-7 [pii]
AID - 10.1007/s11033-023-08384-7 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2023 Jun;50(6):5407-5414. doi: 10.1007/s11033-023-08384-7. Epub 
      2023 Apr 20.