PMID- 37084357
OWN - NLM
STAT- MEDLINE
DCOM- 20230919
LR  - 20230921
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 10
DP  - 2023 Sep 18
TI  - Sleep Patterns, Plasma Metabolome, and Risk of Incident Type 2 Diabetes Mellitus.
PG  - e1034-e1043
LID - 10.1210/clinem/dgad218 [doi]
AB  - CONTEXT: A healthy sleep pattern has been related to a lower risk of type 2 
      diabetes mellitus (T2DM). OBJECTIVE: We aimed to identify the metabolomic 
      signature for the healthy sleep pattern and assess its potential causality with 
      T2DM. METHODS: This study included 78 659 participants with complete phenotypic 
      data (sleep information and metabolomic measurements) from the UK Biobank study. 
      Elastic net regularized regression was applied to calculate a metabolomic 
      signature reflecting overall sleep patterns. We also performed genome-wide 
      association analysis of the metabolomic signature and one-sample mendelian 
      randomization (MR) with T2DM risk. RESULTS: During a median of 8.8 years of 
      follow-up, we documented 1489 incident T2DM cases. Compared with individuals who 
      had an unhealthy sleep pattern, those with a healthy sleep pattern had a 49% 
      lower risk of T2DM (multivariable-adjusted hazard ratio [HR], 0.51; 95% CI, 
      0.40-0.63). We further constructed a metabolomic signature using elastic net 
      regularized regressions that comprised 153 metabolites, and robustly correlated 
      with sleep pattern (r = 0.19; P = 3x10-325). In multivariable Cox regressions, 
      the metabolomic signature showed a statistically significant inverse association 
      with T2DM risk (HR per SD increment in the signature, 0.56; 95% CI, 0.52-0.60). 
      Additionally, MR analyses indicated a significant causal relation between the 
      genetically predicted metabolomic signature and incident T2DM (P for trend < 
      .001). CONCLUSION: In this large prospective study, we identified a metabolomic 
      signature for the healthy sleep pattern, and such a signature showed a potential 
      causality with T2DM risk independent of traditional risk factors.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Zhuang, Zhenhuang
AU  - Zhuang Z
AD  - Department of Epidemiology & Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China.
FAU - Dong, Xue
AU  - Dong X
AD  - Department of Epidemiology & Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China.
FAU - Jia, Jinzhu
AU  - Jia J
AD  - Department of Biostatistics, School of Public Health, Peking University, Beijing 
      100191, China.
FAU - Liu, Zhonghua
AU  - Liu Z
AUID- ORCID: 0000-0003-3048-9823
AD  - Department of Biostatistics, Columbia University, New York, NY 10027-6902, USA.
FAU - Huang, Tao
AU  - Huang T
AUID- ORCID: 0000-0002-0328-1368
AD  - Department of Epidemiology & Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China.
AD  - Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of 
      Education, Beijing 100191, China.
AD  - Center for Intelligent Public Health, Institute for Artificial Intelligence, 
      Peking University, Beijing 100191, China.
FAU - Qi, Lu
AU  - Qi L
AUID- ORCID: 0000-0002-8041-7791
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA 70118, USA.
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 
      02115, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Genome-Wide Association Study
MH  - Prospective Studies
MH  - Risk Factors
MH  - Metabolome
MH  - Mendelian Randomization Analysis
OTO - NOTNLM
OT  - causality
OT  - genetics
OT  - metabolome
OT  - sleep
OT  - type 2 diabetes mellitus
EDAT- 2023/04/21 18:42
MHDA- 2023/09/19 06:43
CRDT- 2023/04/21 16:32
PHST- 2022/11/15 00:00 [received]
PHST- 2023/09/19 06:43 [medline]
PHST- 2023/04/21 18:42 [pubmed]
PHST- 2023/04/21 16:32 [entrez]
AID - 7135926 [pii]
AID - 10.1210/clinem/dgad218 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Sep 18;108(10):e1034-e1043. doi: 
      10.1210/clinem/dgad218.