PMID- 37084693
OWN - NLM
STAT- MEDLINE
DCOM- 20230502
LR  - 20230502
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1697
DP  - 2023 May 24
TI  - Development of electrospun nanofibers based on Poly (vinyl alcohol) for thin film 
      solid-phase microextraction of antidepressant drugs in biological samples.
PG  - 463984
LID - S0021-9673(23)00210-8 [pii]
LID - 10.1016/j.chroma.2023.463984 [doi]
AB  - Today, antidepressants are widely used and it is important to determine their 
      trace amounts due to harmful consequences. Here, a new nano sorbent was reported 
      for the simultaneous extraction and determination of three types of 
      antidepressant drugs (Clomipramine (CLO), Clozapine (CLZ), and Trimipramine (TRP) 
      by the thin-film solid-phase micro-extraction (TFME-muSPE) method followed by the 
      Gas Chromatography-flame ionization detector (GC-FID) analysis. So, the compound 
      poly (vinyl alcohol) (PVA)/citric acid(CA)/beta-cyclodextrin/Bi(2)S(3)@g-C(3)N(4) 
      nano sorbent was constructed by electrospinning technique. Then, nano sorbent was 
      studied to optimize the many parameters impacting the extraction performance. 
      Electrospun nanofiber has a large surface area, high porosity, and homogeneous 
      morphology with a uniform bead-free structure. In optimal conditions, the limits 
      of detection and quantification were calculated to be 0.15-0.03 ng mL(-1) and 
      0.5-0.1 ng mL(-1), respectively. The dynamic linear range (DLR) was in the range 
      of 0.1 to 1000 ng mL(-1) for CLO and CLZ, and 0.5 to 1000 ng mL(-1) for TRP with 
      correlation coefficients (R(2)) of 0.999. The relative standard deviations (RSDs) 
      were achieved in the range of 4.9-6.8% (intra-day, n = 4) and 5.4-7.9% 
      (inter-day, n = 3) in the period of 3 days. Finally, the capability of the method 
      was evaluated to simultaneously measure trace amounts of antidepressants aqueous 
      sample with desirable extraction efficiency (78 to 95%).
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Hosseini, Fatemeh Sadat
AU  - Hosseini FS
AD  - Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and 
      Petroleum Sciences, Shahid Beheshti University, Tehran, Iran.
FAU - Kharazmi, Farbod
AU  - Kharazmi F
AD  - Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and 
      Petroleum Sciences, Shahid Beheshti University, Tehran, Iran.
FAU - Davarani, Saied Saeed Hosseiny
AU  - Davarani SSH
AD  - Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and 
      Petroleum Sciences, Shahid Beheshti University, Tehran, Iran. Electronic address: 
      ss-hosseiny@sbu.ac.ir.
FAU - Ebrahimzadeh, Homeira
AU  - Ebrahimzadeh H
AD  - Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and 
      Petroleum Sciences, Shahid Beheshti University, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230412
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - *Polyvinyl Alcohol
MH  - *Nanofibers/chemistry
MH  - Solid Phase Microextraction/methods
MH  - Solid Phase Extraction
MH  - Antidepressive Agents
MH  - Limit of Detection
OTO - NOTNLM
OT  - Antidepressant drugs
OT  - Biological samples
OT  - Composite nanofibers
OT  - Electrospinning
OT  - Thin-film solid-phase micro-extraction
COIS- Declaration of Competing Interest The authors declare that they have no competing 
      interests.
EDAT- 2023/04/22 10:42
MHDA- 2023/05/02 06:41
CRDT- 2023/04/21 18:11
PHST- 2023/01/09 00:00 [received]
PHST- 2023/03/29 00:00 [revised]
PHST- 2023/04/07 00:00 [accepted]
PHST- 2023/05/02 06:41 [medline]
PHST- 2023/04/22 10:42 [pubmed]
PHST- 2023/04/21 18:11 [entrez]
AID - S0021-9673(23)00210-8 [pii]
AID - 10.1016/j.chroma.2023.463984 [doi]
PST - ppublish
SO  - J Chromatogr A. 2023 May 24;1697:463984. doi: 10.1016/j.chroma.2023.463984. Epub 
      2023 Apr 12.