PMID- 37086592
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20230619
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Print)
IS  - 0033-3506 (Linking)
VI  - 219
DP  - 2023 Jun
TI  - Smoking habits predict adverse effects after mRNA COVID-19 vaccine: Empirical 
      evidence from a pilot study.
PG  - 18-21
LID - S0033-3506(23)00101-4 [pii]
LID - 10.1016/j.puhe.2023.03.013 [doi]
AB  - OBJECTIVES: The aim of this research was to investigate the possible association 
      between smoking habits and the incidence of adverse effects (AEs) after mRNA 
      COVID-19 vaccine. STUDY DESIGN: A longitudinal observational study was conducted 
      on a sample of Italian healthcare workers. METHODS: Healthcare workers who were 
      administered the mRNA COVID-19 vaccine (either BNT162b2 or mRNA-1273) were 
      evaluated for the occurrence of AEs after three vaccine doses. Multivariate 
      Poisson regression analyses were fitted to predict AE risk according to smoking 
      characteristics - such as number of tobacco cigarettes smoked per day, smoking 
      time, and use of electronic cigarette (e-cig). RESULTS: Of 320 total 
      participants, 72 (22.5%) smoked cigarettes, and 50 (15.6%) used e-cig, 49 of 
      which being dual users. Tobacco smoking significantly increased the risks of 
      muscle and joint pain during the primary COVID-19 vaccination cycle and of chills 
      during the whole vaccination series. The number of cigarettes smoked per day and 
      vaping variously predicted AE onset during the whole cycle, with a tendency to 
      respectively reduce and increase their risks. Duration of smoking did not affect 
      any AE, except for headache after the booster dose. Most results remained 
      significant after Bonferroni adjustment of significance level. CONCLUSION: Our 
      pilot study indicated a possible effect of smoking habits on AE onset. Our 
      research offers evidence that helps understanding possible predictors of the 
      interindividual variability in COVID-19 vaccine response, serving as a reference 
      for further studies on the effect of smoking on vaccine safety and effectiveness.
CI  - Copyright (c) 2023 The Royal Society for Public Health. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Ponticelli, D
AU  - Ponticelli D
AD  - Pineta Grande Hospital, Castel Volturno, Italy.
FAU - Losa, L
AU  - Losa L
AD  - Center for Public Health Research, University of Milan-Bicocca, Monza, Italy.
FAU - Campagna, D
AU  - Campagna D
AD  - Department of Clinical and Experimental Medicine, University of Catania, Catania, 
      Italy; UOC MCAU, University Teaching Hospital "Policlinico-Vittorio Emanuele", 
      University of Catania, Catania, Italy.
FAU - Magliuolo, R
AU  - Magliuolo R
AD  - Pineta Grande Hospital, Castel Volturno, Italy.
FAU - Vitale, A
AU  - Vitale A
AD  - Pineta Grande Hospital, Castel Volturno, Italy.
FAU - Cacciapuoti, D
AU  - Cacciapuoti D
AD  - Pineta Grande Hospital, Castel Volturno, Italy.
FAU - Zampella, A
AU  - Zampella A
AD  - Pineta Grande Hospital, Castel Volturno, Italy.
FAU - Alleanza, L
AU  - Alleanza L
AD  - Pineta Grande Hospital, Castel Volturno, Italy.
FAU - Schiavone, B
AU  - Schiavone B
AD  - Pineta Grande Hospital, Castel Volturno, Italy.
FAU - Spicuzza, L
AU  - Spicuzza L
AD  - Department of Clinical and Experimental Medicine, University of Catania, Catania, 
      Italy; Respiratory Unit, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy.
FAU - Ferrara, P
AU  - Ferrara P
AD  - Center for Public Health Research, University of Milan-Bicocca, Monza, Italy; 
      Istituto Auxologico Italiano-IRCCS, 20165 Milan, Italy. Electronic address: 
      p.ferrara5@campus.unimib.it.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20230321
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (BNT162 Vaccine)
RN  - 0 (Vaccines)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Humans
MH  - Smoking/epidemiology
MH  - COVID-19 Vaccines/adverse effects
MH  - Pilot Projects
MH  - *Smoking Cessation/methods
MH  - *Electronic Nicotine Delivery Systems
MH  - BNT162 Vaccine
MH  - *COVID-19/epidemiology/prevention & control
MH  - *Vaccines
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - RNA, Messenger
PMC - PMC10028337
OTO - NOTNLM
OT  - Adverse effects after immunisation
OT  - SARS-CoV-2
OT  - Safety
OT  - Smoking
OT  - mRNA COVID-19 vaccine
COIS- None declared.
EDAT- 2023/04/23 00:41
MHDA- 2023/06/19 13:08
PMCR- 2023/03/21
CRDT- 2023/04/22 18:04
PHST- 2023/01/30 00:00 [received]
PHST- 2023/03/06 00:00 [revised]
PHST- 2023/03/10 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/04/23 00:41 [pubmed]
PHST- 2023/04/22 18:04 [entrez]
PHST- 2023/03/21 00:00 [pmc-release]
AID - S0033-3506(23)00101-4 [pii]
AID - 10.1016/j.puhe.2023.03.013 [doi]
PST - ppublish
SO  - Public Health. 2023 Jun;219:18-21. doi: 10.1016/j.puhe.2023.03.013. Epub 2023 Mar 
      21.