PMID- 37087604
OWN - NLM
STAT- MEDLINE
DCOM- 20230509
LR  - 20230919
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 41
IP  - 5
DP  - 2023 May 8
TI  - [Development of a multi-residue detection method for 27 typical pharmaceuticals 
      and personal-care products in plants and analysis of their migration patterns in 
      sprouts].
PG  - 386-396
LID - 10.3724/SP.J.1123.2022.09017 [doi]
AB  - An analytical method based on ultra-performance liquid chromatography-tandem mass 
      spectrometry was developed for the simultaneous determination of 27 
      pharmaceutical and personal-care product (PPCP) residues in plants. The 
      enrichment and cleanup of PPCPs in plants were achieved using an HLB extraction 
      column, and the separation was performed on a BEH C18 column (100 mmx2.1 mm, 1.7 
      mum) with 0.1% formic acid water-acetonitrile as the mobile phase via gradient 
      elution. PPCPs were detected with electrospray ionization mass spectrometry in 
      positive-ion multiple-reaction monitoring (MRM) mode. The limits of detection and 
      quantification of the 27 PPCPs in plants were 0.01-0.30 mug/kg and 0.03-0.98 
      mug/kg, respectively. Good linearities were observed with coefficients of 
      determination (r(2)) >0.99. The spiked recoveries were between 80.8% and 122.3% 
      with relative standard deviations (RSDs) between 1.0% and 9.9%. The method was 
      subsequently used to study sprouts grown in different concentrations of PPCPs. A 
      total of 10 PPCPs were detected in sprouts grown in medium with a low 
      concentration PPCPs, 13 PPCPs were detected in sprouts grown in medium with a 
      moderate concentration of PPCPs, and 19 PPCPs were detected in sprouts grown in 
      medium with a high concentration of PPCPs. These results showed that plants grown 
      in water bodies contaminated with PPCPs or irrigated with water contaminated with 
      PPCPs absorbed and accumulated these substances and that the amount and type of 
      PPCPs absorbed by plants were closely related to the levels of PPCPs in the 
      external environment. Analysis of the contents of PPCPs in different plant 
      tissues revealed a general distribution of root>stem>leaf. Haemosibutramine 
      showed a tissue distribution of leaf>stem>root, while glibenclamide showed a 
      distribution of root>leaf>stem; these results revealed differences in the 
      distribution of PPCPs in plants. Calculation of the transfer factor (TF) of the 
      PPCPs in plants demonstrated significant differences in the transferability of 
      different PPCPs, with TF=2.34 for haemosibutramine and TF=1.25 for 
      chlorosibutramine. The results showed that among the drugs that migrated in 
      plants, haemonosibutramine and chlorosibutramine had the strongest migration 
      ability in sprouts, followed by nicardipine and chlorpheniramine maleate, and 
      amantadine, N-monodesmethyl sibutramine, carbamazepine and flumequine had the 
      weakest migration ability. Once absorbed, these compounds were transferred to the 
      stems and/or leaves, where they accumulate and cause potential harm by 
      contaminating other plant organs. Therefore, PPCPs such as homosibutramine and 
      chlorosibutramine, which easily migrate in plants, should be given extra 
      attention in future studies. The method is simple in pre-treatment, sensitive and 
      accurate, and can be widely applied to the detection of PPCP residues in plant 
      samples.
FAU - Zeng, Yong-Fu
AU  - Zeng YF
AD  - School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
AD  - Hebei Key Laboratory of Environment and Population Health, Shijiazhuang 050017, 
      China.
FAU - Chen, Mei-Fang
AU  - Chen MF
AD  - School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
AD  - Hebei Key Laboratory of Environment and Population Health, Shijiazhuang 050017, 
      China.
FAU - Shao, Yu
AU  - Shao Y
AD  - China National Accreditation Service for Conformity Assessment, Beijing 100062, 
      China.
FAU - Yan, Yong-Huan
AU  - Yan YH
AD  - School of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, 
      China.
FAU - Zhang, Hai-Chao
AU  - Zhang HC
AD  - Shijiazhuang Customs Technology Center, Shijiazhuang 050051, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Shijiazhuang Customs Technology Center, Shijiazhuang 050051, China.
FAU - Ai, Lian-Feng
AU  - Ai LF
AD  - School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
AD  - Hebei Key Laboratory of Environment and Population Health, Shijiazhuang 050017, 
      China.
AD  - Shijiazhuang Customs Technology Center, Shijiazhuang 050051, China.
FAU - Kang, Wei-Jun
AU  - Kang WJ
AD  - School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
AD  - Hebei Key Laboratory of Environment and Population Health, Shijiazhuang 050017, 
      China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Cosmetics)
RN  - 0 (Pharmaceutical Preparations)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Chromatography, Liquid
MH  - *Cosmetics/analysis
MH  - Pharmaceutical Preparations
MH  - Solid Phase Extraction/methods
MH  - *Tandem Mass Spectrometry/methods
MH  - Water
MH  - Seedlings/chemistry
MH  - Drug Residues/analysis
PMC - PMC10122767
OTO - NOTNLM
OT  - pharmaceuticals and personal care products (PPCPs)
OT  - sprouts
OT  - transfer factors
OT  - ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
EDAT- 2023/04/23 06:41
MHDA- 2023/04/25 06:42
PMCR- 2023/05/08
CRDT- 2023/04/23 03:12
PHST- 2023/04/25 06:42 [medline]
PHST- 2023/04/23 06:41 [pubmed]
PHST- 2023/04/23 03:12 [entrez]
PHST- 2023/05/08 00:00 [pmc-release]
AID - 10.3724/SP.J.1123.2022.09017 [doi]
PST - ppublish
SO  - Se Pu. 2023 May 8;41(5):386-396. doi: 10.3724/SP.J.1123.2022.09017.