PMID- 37089080
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230609
IS  - 1759-7714 (Electronic)
IS  - 1759-7706 (Print)
IS  - 1759-7706 (Linking)
VI  - 14
IP  - 16
DP  - 2023 Jun
TI  - Whole-exome sequencing in primary pulmonary synovial sarcoma misdiagnosed as 
      mesothelioma: A case report and literature review.
PG  - 1520-1529
LID - 10.1111/1759-7714.14876 [doi]
AB  - Synovial sarcoma is a highly malignant tumor that accounts for 10% of all soft 
      tissue sarcomas. Primary pulmonary synovial sarcoma (PPSS) is extremely rare, and 
      its prognosis is poor. A diagnosis is usually established after other primary 
      lung malignancies or metastatic extrathoracic sarcomas have been excluded. 
      Therefore, it is often misdiagnosed. In this study, we report the case of a 
      38-year-old woman who was misdiagnosed as having pleural mesothelioma and finally 
      endured surgery to remove the tumor. The tumor showed SYT-SSX fusion transcripts 
      and was diagnosed as PPSS after combining histopathological and 
      immunohistochemical analyses. Finally, we determined some biomarkers through 
      whole-exome sequencing (WES) to improve the diagnosis and treatment strategies.
CI  - (c) 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and 
      John Wiley & Sons Australia, Ltd.
FAU - Wu, Di
AU  - Wu D
AUID- ORCID: 0000-0003-4640-8063
AD  - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
FAU - Zhang, Hongbing
AU  - Zhang H
AD  - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
FAU - Li, Xin
AU  - Li X
AD  - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
FAU - Liu, Jinghao
AU  - Liu J
AD  - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
FAU - Liu, Minghui
AU  - Liu M
AD  - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
FAU - Liu, Hongyu
AU  - Liu H
AD  - Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, 
      Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
FAU - Dong, Ming
AU  - Dong M
AD  - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
AD  - Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, 
      Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, 
      Tianjin, People's Republic of China.
LA  - eng
PT  - Case Reports
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230423
PL  - Singapore
TA  - Thorac Cancer
JT  - Thoracic cancer
JID - 101531441
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Female
MH  - Humans
MH  - Adult
MH  - *Sarcoma, Synovial/diagnosis/genetics/surgery
MH  - Exome Sequencing
MH  - *Lung Neoplasms/diagnosis/genetics/surgery
MH  - *Mesothelioma, Malignant
MH  - *Mesothelioma
MH  - Diagnostic Errors
MH  - Oncogene Proteins, Fusion/genetics
MH  - Biomarkers, Tumor/genetics
PMC - PMC10234783
OTO - NOTNLM
OT  - anlotinib
OT  - diagnosis and treatment
OT  - primary pulmonary synovial sarcoma
OT  - whole-exome sequencing
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/04/24 06:41
MHDA- 2023/06/05 06:42
PMCR- 2023/04/23
CRDT- 2023/04/24 03:03
PHST- 2023/03/16 00:00 [revised]
PHST- 2023/02/19 00:00 [received]
PHST- 2023/03/18 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/04/24 06:41 [pubmed]
PHST- 2023/04/24 03:03 [entrez]
PHST- 2023/04/23 00:00 [pmc-release]
AID - TCA14876 [pii]
AID - 10.1111/1759-7714.14876 [doi]
PST - ppublish
SO  - Thorac Cancer. 2023 Jun;14(16):1520-1529. doi: 10.1111/1759-7714.14876. Epub 2023 
      Apr 23.