PMID- 37089877
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230903
IS  - 2572-4754 (Electronic)
IS  - 2572-4754 (Linking)
VI  - 6
DP  - 2022
TI  - Systematic review: Safety of surgical male circumcision in context of HIV 
      prevention public health programmes.
PG  - 164
LID - 10.12688/gatesopenres.13730.2 [doi]
LID - 164
AB  - Background: Since the recommendation of voluntary medical male circumcision 
      (VMMC) to reduce the risk of heterosexually acquired HIV, a number of adolescent 
      boys and men in 15 priority countries in Africa have been circumcised. Our 
      primary goal was to identify the incidence of adverse events (AEs) associated 
      with VMMC and to assess the safety profile among adolescent boys 10 - 14 years. 
      Methods: We searched the databases MEDLINE and Embase, WHO, and conference 
      abstracts from 2005 to 2019. The incidence of AEs was estimated by type of AE, 
      size of study and age. Results: We retained 40 studies. Severe and moderate AEs 
      overall were estimated at 0.30 per 100 VMMC clients with wide variability per 
      study type. A higher rate was noted in small and moderate scale programmes and 
      device method research studies compared with larger scale programmes. There was a 
      limited number of studies reporting AEs among younger adolescent boys and they 
      had higher infection-related AEs than those aged 20 years and older. Case studies 
      noted rare AEs such as necrotizing fasciitis, tetanus, and glans injury. 
      Conclusions: AE rates were comparable to those from the randomized controlled 
      trials (RCTs) that led to recommendations and implementation of VMMC in high HIV 
      burden countries, despite being implemented in low resource settings. Clients 
      over time have increasingly included adolescents under the age of 15 years. 
      Studies suggest potentially higher risks in this age group. As VMMC services are 
      sustained, patient safety surveillance systems and promoting a patient safety 
      culture are crucial to identify and mitigate potential harms from medical male 
      circumcision.
CI  - Copyright: (c) 2023 Jindai K et al.
FAU - Jindai, Kazuaki
AU  - Jindai K
AUID- ORCID: 0000-0003-4679-3862
AD  - Department of Virology, Tohoku University, Sendai, Japan.
AD  - Department of Healthcare Epidemiology, Kyoto University, Kyoto, Japan.
FAU - Farley, Tim
AU  - Farley T
AD  - Sigma3 Services, Nyon, Switzerland.
FAU - Awori, Quentin
AU  - Awori Q
AD  - Kenya Medical Research Institute, Nairobi, Kenya.
FAU - Temu, Anaelia-Siya
AU  - Temu AS
AD  - World Health Organization, Geneva, Switzerland.
FAU - Ndenzako, Fabian
AU  - Ndenzako F
AD  - World Health Organization, Regional Office for Africa, Brazzaville, Congo.
FAU - Samuelson, Julia
AU  - Samuelson J
AUID- ORCID: 0000-0001-8217-8344
AD  - World Health Organization, Geneva, Switzerland.
LA  - eng
SI  - figshare/10.6084/m9.figshare.21541392
GR  - 001/WHO_/World Health Organization/International
PT  - Systematic Review
DEP - 20230503
PL  - United States
TA  - Gates Open Res
JT  - Gates open research
JID - 101717821
PMC - PMC10115943
OTO - NOTNLM
OT  - Africa
OT  - adolescent
OT  - adverse event
OT  - human immunodeficiency virus infection
OT  - male urologic surgical procedures
OT  - voluntary medical male circumcision
COIS- No competing interests were disclosed.
EDAT- 2023/04/24 06:42
MHDA- 2023/04/24 06:43
PMCR- 2023/05/03
CRDT- 2023/05/05 03:47
PHST- 2023/04/27 00:00 [accepted]
PHST- 2023/04/24 06:43 [medline]
PHST- 2023/04/24 06:42 [pubmed]
PHST- 2023/05/05 03:47 [entrez]
PHST- 2023/05/03 00:00 [pmc-release]
AID - 10.12688/gatesopenres.13730.2 [doi]
PST - epublish
SO  - Gates Open Res. 2023 May 3;6:164. doi: 10.12688/gatesopenres.13730.2. eCollection 
      2022.