PMID- 37090883
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230425
IS  - 2378-8038 (Print)
IS  - 2378-8038 (Electronic)
IS  - 2378-8038 (Linking)
VI  - 8
IP  - 2
DP  - 2023 Apr
TI  - Treatment and outcome among patients with laryngeal squamous cell carcinoma in 
      Stockholm-A population-based study.
PG  - 441-449
LID - 10.1002/lio2.1034 [doi]
AB  - OBJECTIVE: Survival of patients with advanced laryngeal squamous cell carcinoma 
      (LSCC) remains poor and management protocols warrant further development. We thus 
      investigated treatment and outcome-related factors for LSCC in Stockholm, Sweden. 
      METHODS: In a retrospective setting, 520 patients with LSCC diagnosed during 
      2000-2014, were included. Data on stage, treatment, and outcome were correlated 
      with recurrence-free and overall survival (RFS and OS, respectively). RESULTS: 
      Five-year OS for all patients was 65%. Five-year RFS for T1a, T1b, T2, T3, and T4 
      glottic LSCC was 90%, 91%, 77%, 47%, and 80%, respectively. The corresponding 
      figures for T1, T2, T3, and T4 supraglottic LSCC were 64%, 66%, 64%, and 86%. 
      CONCLUSION: Patients with a T3 glottic LSCC had unexpectedly poor survival, 
      especially when compared with patients with a T4 tumor. Patients with T4 disease 
      were primarily treated with laryngectomy and postoperative radiotherapy 
      (RT)/chemoradiotherapy (CRT), while most patients with T3 LSCC were treated with 
      RT/CRT.
CI  - (c) 2023 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley 
      Periodicals LLC on behalf of The Triological Society.
FAU - Blomkvist, Rasmus
AU  - Blomkvist R
AUID- ORCID: 0000-0001-8581-1694
AD  - Division of ENT Diseases, Department of Clinical Science Intervention and 
      Technology, Karolinska Institutet Stockholm Sweden.
AD  - Department of Otorhinolaryngology Karolinska University Hospital Stockholm 
      Sweden.
FAU - Marklund, Linda
AU  - Marklund L
AD  - Division of ENT Diseases, Department of Clinical Science Intervention and 
      Technology, Karolinska Institutet Stockholm Sweden.
AD  - Medical Unit, Head Neck, Lung and Skin Cancer Karolinska University Hospital 
      Stockholm Sweden.
FAU - Hammarstedt-Nordenvall, Lalle
AU  - Hammarstedt-Nordenvall L
AD  - Division of ENT Diseases, Department of Clinical Science Intervention and 
      Technology, Karolinska Institutet Stockholm Sweden.
AD  - Medical Unit, Head Neck, Lung and Skin Cancer Karolinska University Hospital 
      Stockholm Sweden.
FAU - Gottlieb-Vedi, Eivind
AU  - Gottlieb-Vedi E
AD  - Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery 
      Karolinska Institutet and Karolinska University Hospital Stockholm Sweden.
FAU - Makitie, Antti
AU  - Makitie A
AD  - Division of ENT Diseases, Department of Clinical Science Intervention and 
      Technology, Karolinska Institutet Stockholm Sweden.
AD  - Department of Otorhinolaryngology - Head and Neck Surgery University of Helsinki 
      and Helsinki University Hospital Helsinki Finland.
FAU - Palmgren, Bjorn
AU  - Palmgren B
AD  - Division of ENT Diseases, Department of Clinical Science Intervention and 
      Technology, Karolinska Institutet Stockholm Sweden.
AD  - Medical Unit, Head Neck, Lung and Skin Cancer Karolinska University Hospital 
      Stockholm Sweden.
LA  - eng
PT  - Journal Article
DEP - 20230306
PL  - United States
TA  - Laryngoscope Investig Otolaryngol
JT  - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC10116984
OTO - NOTNLM
OT  - clinical outcome
OT  - glottic
OT  - head and neck cancer
OT  - laryngeal squamous cell carcinoma
OT  - supraglottic
COIS- Eivind Gottlieb-Vedi declares employment at Sanofi.
EDAT- 2023/04/24 06:42
MHDA- 2023/04/24 06:43
PMCR- 2023/03/06
CRDT- 2023/04/24 03:47
PHST- 2022/12/12 00:00 [received]
PHST- 2023/01/30 00:00 [revised]
PHST- 2023/02/19 00:00 [accepted]
PHST- 2023/04/24 06:43 [medline]
PHST- 2023/04/24 06:42 [pubmed]
PHST- 2023/04/24 03:47 [entrez]
PHST- 2023/03/06 00:00 [pmc-release]
AID - LIO21034 [pii]
AID - 10.1002/lio2.1034 [doi]
PST - epublish
SO  - Laryngoscope Investig Otolaryngol. 2023 Mar 6;8(2):441-449. doi: 
      10.1002/lio2.1034. eCollection 2023 Apr.